STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO3678Putative deoxynucleotide triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (191 aa)    
Predicted Functional Partners:
SCO5868
Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
    
 0.929
SCO2612
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
  
 
 0.927
SCO1776
Putative CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
  
 
 0.925
SCO3677
SCH35.47, possible purine phosphoribosyltransferase, len: 165 aa; similar to many eg. TR:P74916 (EMBL:D37928) purine phosphoribosyltransferase from Thermus flavus (154 aa) fasta scores; opt: 222, z-score: 291.9, E(): 6.3e-09, 931.8% identity in 151 aa overlap).
       0.833
SCO2383
SC4A7.11, possible secreted protein, len: 1545 aa; similar in its central part to SW:STFR_ECOLI (EMBL:AE000234) Escherichia coli side tail fiber protein homolog from labmboid prophage RAC StfR or B1372, 1120 aa; fasta scores: opt: 494 Z-score: 414.4 E(): 1.9e-15; 31.461% identity in 445 aa overlap. Contains high percentage of aa residues A and G. Contains Pfam match to entry PF00652 Ricin_B_lectin, Similarity to lectin domain of ricin beta-chain and possible N-terminal region signal peptide sequence. Also contains possible colied-coil regions at approx. residues 655..761, 789..846 and [...]
      
 0.770
SCO3117
Hypothetical protein SCE41.26; SCE41.26, unknown, len: 176 aa.
      
 0.770
SCP1.202
Hypothetical protein; SCP1.202, unknown, len: 167aa.
      
 0.770
SCO7194
SC8A11.22, possible polysaccharide biosynthesis protein, len: 271 aa; similar to N-terminal region of SW:SPSK_BACSU (EMBL:X73124) Bacillus subtilis spore coat polysaccharide biosynthesis protein SpsK, 432 aa; fasta scores: opt: 278 z-score: 331.5 E(): 5.3e-11; 28.1% identity in 242 aa overlap.
   
    0.698
SCO6075
Conserved hypothetical protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.
     
 0.658
SCO1945
Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P).
  
  
 0.591
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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