STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
SCO3716Putative cation transport system component; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. (225 aa)    
Predicted Functional Partners:
SCO3717
Putative cation transport system component; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
 
 
 0.999
SCO3718
Putative cation transport system component; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane.
 
 0.999
SCO5871
Putative turgor pressure sensor; SC2E9.12, kdpD, two-component sensor/protein kinase, len: 848 aa; similar to Escherichia coli turgor pressure sensor KDPD_ECOLI P21865 sensor protein kdpD (ec 2.7.3.-) (894 aa), fasta scores; opt: 997 z-score: 1347.4 E(): 0, 34.8% identity in 877 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and Pfam match to entry signal PF00512, Signal C terminal domain, score 184.57. Contains possible hydrophobic membrane spanning regions.
 
  
 0.973
SCO5872
Putative turgor pressure regulator; SC2E9.13, kdpE, two-component trascriptional regulator, len: 227, similar to E.coli turgor pressure regulator KDPE_ECOLI P21866 kdp operon transcriptional regulatory protein (225 aa), fasta scores; opt: 752 z-score: 1090.9 E(): 0, 51.1% identity in 225 aa overlap. Contains Pfam match to entry trans_reg_C PF00486, Transcriptional regulatory proteins, C terminal, score 96.22.
 
  
 0.789
SCO1596
SCI35.18c, probable two-component sensor, len: 379 aa; similar to many e.g. HYDH_ECOLI sensor protein hydH (465 aa), fasta scores; opt: 296 z-score: 418.4 E(): 4.6e-16, 35.4% identity in 257 aa overlap. No apparent transmembrane domains. Contains Pfam match to entry PF00512 signal, Signal carboxyl-terminal domain, score 205.10, E-value 1e-57.
  
  
 0.784
SCO7425
SC6D11.21, possible multidrug-efflux transporter protein, len: 577 aa. Highly similar to several including: Streptomyces virginiae TR:Q9XE01(EMBL:AB019519) virginiamycin S resistance protein, VarS (518 aa), fasta scores opt: 322 z-score: 328.6 E(): 7e-11 25.7% identity in 536 aa overlap and Deinococcus radiodurans TR:AAF11851(EMBL:AE002062) multidrug-efflux transporter, putative (410 aa), fasta scores opt: 937 z-score: 945.6 E(): 0 41.3% identity in 395 aa overlap. Contains a Pfam match to entry PF00083 sugar_tr, Sugar (and other) transporter and multiple possible membrane spanning hyd [...]
  
  
 0.654
SCO1160
SCG8A.14c, cvnA3, possible membrane protein, len: 862 aa; similar to many from Streptomyces coelicolor e.g. TR:Q9X836 (EMBL:AL049727) putative large secreted protein (877 aa) fasta scores; opt: 1248, z-score: 1146.3, E(): 0, 34.7% identity in 836 aa overlap. Contains possible membrane-spanning hydrophobic regions.
  
  
 0.650
SCO4155
SCD84.22c, probable two-component system sensor, len: 481 aa; similar to TR:O53895 (EMBL:AL021999) Mycobacterium tuberculosis putative two-component sensor, MTV044.10, 504 aa; fasta scores: opt: 884 z-score: 949.8 E(): 0; 39.4% identity in 482 aa overlap and to SW:AFQ2_STRCO (EMBL:D10654) Streptomyces coelicolor sensor protein AfsQ2 (EC 2.7.3.-), 535 aa; fasta scores: opt: 404 z-score: 435.9 E(): 8e-17; 31.4% identity in 526 aa overlap. Contains Pfam matches to entries PF00672 DUF5, Domain found in bacterial signal proteins and PF00512 signal, Histidine kinase and correctly situated ma [...]
  
  
 0.650
SCO5282
SCCB12.06c, possible two-component system sensor kinase, len: 375 aa; similar to SW:AFQ2_STRCO (EMBL:D10654) Streptomyces coelicolor sensor protein AfsQ2, 535 aa; fasta scores: opt: 344 z-score: 382.3 E(): 7.9e-14; 32.5% identity in 335 aa overlap. Contains Pfam matches to entries PF00672 DUF5, HAMP domain and PF00512 signal, Histidine kinase. Also contains possible hydrophobic membrane spanning regions.
  
  
 0.650
SCO5289
Putative two component sensor kinase; SCCB12.13, cvnA5, hypothetical protein (fragment), len: >191 aa; similar to C-terminal region of TR:O86525 (EMBL:AL031124) Streptomyces coelicolor hypothetical 139.7 kDa protein SC1C2.25c, 1329 aa; fasta scores: opt: 146 z-score: 152.5 E(): 0.5; 25.3% identity in 186 aa overlap. Contains possible hydrophobic membrane spanning region; SC6G9.44c, possible sensor kinase, len: 806 aa; weak similarity to part of TR:O33492 (EMBL:AJ000330), StyS, Pseudomonas sp. strain Y2 styrene sensor kinase (982 aa), fasta scores; opt: 256 z-score: 230.5 E(): 1.6e-05, [...]
  
  
 0.650
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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