STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3820SCGD3.21c, probable serine/threonine protein kinase, len: 522 aa; similar to many e.g. (EMBL:AF094711), PksC, Streptomyces coelicolor serine/threonine protein kinase (556 aa), fasta scores; opt: 907 z-score: 635.3 E(): 4.6e-28, 36.6% identity in 558 aa overlap, which lies upstream, on the opposite strand. Similar to mycobacterial putative serine/threonine protein kinases, but divergent at the C-terminal end e.g. TR:P71584 (EMBL:Z80233), PknB, Mycobacterium tuberculosis putative serine/threonine protein kinase (626 aa) (42.3% identity in 437 aa overlap). Contains a hydrophobic, possible [...] (522 aa)    
Predicted Functional Partners:
SCO7530
Putative regulatory protein; SC8G12.06c, possible regulatory protein, len: 360 aa. The N-terminus of this protein is similar to many regulatory proteins e.g. Deinococcus radiodurans TR:AAF11989(EMBL:AE002074) transcriptional regulator, MerR family (280 aa), fasta scores opt: 324 z-score: 367.6 E(): 5.1e-13 37.3% identity in 244 aa overlap. The C-terminus of this protein is similar to many hypothetical proteins and putative phosphatases e.g. Mycobacterium leprae TR:Q50188(EMBL:Z70722) putative phosphoprotein phosphatase (509 aa), fasta scores opt: 709 z-score: 790.9 E(): 0 54.6% identit [...]
 
 
 0.832
SCO3845
SCH69.15, possible protein phosphatase, len: 515aa; similar to many of undefined function egs. TR:P71588 (EMBL:Z80233) hypothetical protein from Mycobacterium tuberculosis (514 aa) fasta scores; opt: 989, z-score: 916.0, E(): 0, (42.9% identity in 536 aa overlap) and TR:Q50188 (EMBL:Z70722) putative phophoprotein phosphatase from Mycobacterium leprae (509 aa) fasta scores; opt: 966, z-score: 895.0, E(): 0, (40.0% identity in 530 aa overlap). Contains 2 Pfam matches to entry PF00481 PP2C, Protein phosphatase 2C. could have a role in signalling.
 
 
 0.821
SCO2667
Hypothetical protein SC6D10.10; SC6D10.10, unknown, len: 482 aa.
 
 
 0.659
SCO1831
SCI8.16, possible oxidoreductase, len: 251 aa. Similar to several including Streptomyces coelicolor TR:CAB52925 (EMBL: AL109949) putative oxidoreductase SCJ11.40 (250 aa), fasta scores opt: 462 z-score: 489.9 E(): 6.4e-20 33.9% identity in 248 aa overlap and Bacillus megaterium SW:DHG2_BACME (EMBL: D90044) glucose 1-dehydrogenase II (EC 1.1.1.47) (GLCDH-II) (261 aa), fasta scores opt: 412 z-score: 437.9 E(): 5e-17 34.6% identity in 254 aa overlap. Contains Pfam matches to entry PF00106 adh_short, short chain dehydrogenase and PF00678 adh_short_C2, Short chain dehydrogenase/reductase C- [...]
      
 0.655
SCO4681
SCD31.06, probable short chain dehydrogenase, len: 296 aa; similar to TR:CAB56135 (EMBL:AL117669) Streptomyces coelicolor putative short chain dehydrogenase SCF12.09, 249 aa; fasta scores: opt: 1003 z-score: 1070.0 E(): 0; 65.2% identity in 244 aa overlap and to SW:SDR1_PICAB (EMBL:X74115) Picea abies short-chain type dehydrogenase/reductase (EC 1.-.-.-) Sdr1,271 aa; fasta scores: opt: 576 z-score: 619.1 E(): 4.7e-27; 47.8% identity in 251 aa overlap. Contains Pfam matches to entries PF00106 adh_short, short chain dehydrogenase and PF00678 adh_short_C2, Short chain dehydrogenase/reduct [...]
      
 0.649
SCO3502
SCE134.03c, possible 3-oxoacyl-[acyl carrier protein] reductase, len: 255 aa; similar to many e.g. SW:FABG_BACSU 3-oxoacyl-[acyl carrier protein] reductase from Bacillus subtilis (246 aa) fasta scores; opt: 522, z-score: 518.3, E(): 1.5e-21, (38.1% identity in 247 aa overlap). Contains Pfam matches to entries PF00678 adh_short_C2, Short chain dehydrogenase/reductase C-terminus and PF00106 adh_short, short chain dehydrogenase.
      
 0.646
SCO6249
SCAH10.14c, probable 3-oxoacyl-[acyl-carrier-protein] reductase, len: 258 aa; similar to TR:CAB42951 (EMBL:AL049863) Streptomyces coelicolor putative dehydrogenase/reductase, SC5H1.26, 245 aa; fasta scores: opt: 560 z-score: 573.5 E(): 1.4e-24; 45.1% identity in 246 aa overlap and to SW:FABG_BACSU (EMBL:U59433) Bacillus subtilis, 3-oxoacyl-[acyl-carrier-protein] reductase, FabG 246 aa; fasta scores: opt: 471 z-score: 484.6 E(): 1.3e-19; 36.0% identity in 247 aa overlap.
      
 0.646
SCO7266
SC5H1.26, probable 3-oxoacyl-[acyl-carrier protein] reductase, len: 245 aa; similar to many short-chain oxidoreductases e.g. SW:FABG_BACSU (EMBL:U59433), FabG, Bacillus subtilis 3-oxoacyl-[acyl-carrier protein] reductase (246 aa), fasta scores; opt: 521 z-score: 562.5 E(): 5.2e-24, 36.6% identity in 246 aa overlap and SW:DHG2_BACME (EMBL:D90044), GdhII, Bacillus megaterium glucose 1-dehydrogenase II (261 aa) (35.3% identity in 249 aa overlap). Similar to SCE134.03c (EMBL:AL049661) possible short chain dehydrogenase (255 aa) (35.1% identity in 242 aa overlap). Contains Pfam matches to e [...]
      
 0.646
SCO1346
2SCG61.28c, fabG3, possible 3-oxoacyl-[acyl-carrier protein] reductase, len: 253 aa; similar to many eg. SW:P25716 (FABG_ECOLI) 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100) from Escherichia coli (244 aa) fasta scores; opt: 624, z-score: 674.0, E(): 4.5e-30, 40.5% identity in 247 aa overlap. Contains Pfam match to entry PF00678 adh_short_C2, Short chain dehydrogenase/reductase C-terminus, Pfam match to entry PF00106 adh_short, short chain dehydrogenase and Prosite match to PS00061 Short-chain dehydrogenases/reductases family signature.
      
 0.645
SCO1384
SC1A8A.04c, hypothetical protein, len: 267aa; similar to but longer than SW:Q50606 (Y0DG_MYCTU) hypothetical protein from Mycobacterium tuberculosis (162 aa) fasta scores; opt: 503, z-score: 488.2, E(): 9.2e-20, 56.0% identity in 141 aa overlap. Contains Pfam match to entry PF00498 FHA, FHA domain.
 
 
   0.557
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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