STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3833SCH69.03c, possible transcriptional regulator, len: 209 aa; similar to many e.g. TR:AAD13556 (EMBL:AF080235) LanK regulator from the landomycin biosynthesis cluster of Streptomyces cyanogenus (192 aa) fasta scores; opt: 201, z-score: 245.8, E(): 2.3e-06, (33.3% identity in 159 aa overlap). Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family and probable helix-turn-helix 31-52 (+5.06 SD). (209 aa)    
Predicted Functional Partners:
SCO3834
SCH69.04c, probable 3-Hydroxyacyl-CoA dehydrogenase, len: 504aa; similar to many eg. TR:O84980 (EMBL:AF029714) PhaC, 3-Hydroxyacyl-CoA dehydrogenase from Pseudomonas putida (505 aa) fasta scores; opt: 1512, z-score: 1634.7, E(): 0, (50.0% identity in 498 aa overlap). Contains Pfam match to entry PF00725 3HCDH, 3-hydroxyacyl-CoA dehydrogenase.
  
    0.875
SCO3835
SCH69.05, possible dehydrogenase, len: 563aa; similar to many eg. SW:PUTA_ECOLI proline dehydrogenase (1320 aa) fasta scores; opt: 256, z-score: 285.1, E(): 1.5e-08, (27.1% identity in 376 aa overlap).
       0.777
SCO7474
SCBAC17A6.07, possible phenylacetic acid degradation protein PaaD, len: 170 aa: similar to many e.g. SW:P76080 (PAAD_ECOLI) phenylacetic acid degradation protein PaaD from Escherichia coli (167 aa) fasta scores; opt: 474, Z-score: 518.6, 45.395% identity (47.586% ungapped) in 152 aa overlap. Contains Pfam match to entry PF01883 DUF59, Domain of unknown function DUF59.
  
     0.608
SCO7471
SCBAC17A6.04, possible phenylacetic acid degradation protein PaaA, len: 328 aa: similar to many e.g. SW:P76077 (PAAA_ECOLI) phenylacetic acid degradation protein PaaA from Escherichia coli (309 aa) fasta scores; opt: 1540, Z-score: 1801.2, 69.967% identity (69.967% ungapped) in 303 aa overlap.
  
     0.517
SCO7475
SCBAC17A6.08, possible phenylacetic acid degradation NADH oxidoreductase PaaE, len: 368 aa; similar to many e.g. SW:P76081 (PAAE_ECOLI) probable phenylacetic acid degradation NADH oxidoreductase PaaE from Escherichia coli (356 aa) fasta scores; opt: 871, Z-score: 943.6, 39.943% identity (40.870% ungapped) in 353 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains; Pfam match to entry PF00175 NAD_binding, Oxidoreductase FAD/NAD-binding domain; Pfam match to entry PF00970 FAD_binding_6, Oxidoreductase FAD-binding domain and Prosite match to P [...]
 
  
 0.512
SCO7473
SCBAC17A6.06, possible phenylacetic acid degradation protein PaaC, len: 275 aa: similar to many e.g. SW:P76079 (PAAC_ECOLI) phenylacetic acid degradation protein PaaC from Escherichia coli (248 aa) fasta scores; opt: 470, Z-score: 547.8, 41.057% identity (44.105% ungapped) in 246 aa overlap.
  
     0.498
SCO7472
SCBAC17A6.05, possible phenylacetic acid degradation protein PaaB, len: 103 aa: similar to many e.g. SW:P76078 (PAAB_ECOLI) phenylacetic acid degradation protein PaaB from Escherichia coli (95 aa) fasta scores; opt: 427, Z-score: 565.4, 66.667% identity (66.667% ungapped) in 90 aa overlap.
 
     0.482
SCO7470
SCBAC17A6.03c, possible phenylacetic acid degradation protein PaaI, len: 170 aa: similar to many e.g. SW:P76084 (PAAI_ECOLI) phenylacetic acid degradation protein PaaI from Escherichia coli (140 aa) fasta scores; opt: 342, Z-score: 414.6, 45.902% identity (46.281% ungapped) in 122 aa overlap. Contains Pfam match to entry PF02584 DUF157, Uncharacterized protein PaaI.
 
     0.446
SCO7469
phenylacetate-CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).
 
     0.408
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: medium (68%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.