STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3883Putative membrane protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins (By similarity). (431 aa)    
Predicted Functional Partners:
SCO6160
Putative SecDF protein-export membrane protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily.
   
 0.999
SCO4722
Preprotein translocase SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
  
 0.998
SCO1944
Protein-export membrane protein; Involved in protein export. Participates in an early event of protein translocation (By similarity); Belongs to the SecG family.
   
 0.992
SCO4646
Preprotein translocase SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
   
 0.990
SCO3881
Putative ribonuclease P component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
  
  
 0.989
SCO3005
Preprotein translocase; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
 
 
 0.987
SCO3882
Hypothetical protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family.
 
  
 0.984
SCO3884
SCH24.06, conserved hypothetical protein, len: 170 aa; previously sequenced as TR:O54595 (EMBL:Y16311) Streptomyces coelicolor jag-like protein (170 aa). Similar to SW:JAG_BACSU (EMBL:Z14225), jag, Bacillus subtilis SpoIIIJ associated protein (208 aa), fasta scores; opt: 231 z-score: 268.4 E(): 1.1e-07, 31.7% identity in 139 aa overlap, and other jag homologs e.g. TR:O53598 (EMBL:AL021426) Mycobacterium tuberculosis hypothetical protein (187 aa) (62.7% identity in 169 aa overlap).
 
  
 0.983
SCO3880
StH24.02, rpmH, probable 50S ribosomal protein L34, len: 45 aa; previously sequenced as SW:RL34_STRCO (EMBL:M82836), rpmH. Similar to many e.g. SW:RL34_STRBI (EMBL:M83112), rpmH, Streptomyces bikiniensis 50S ribosomal protein L34 (45 aa), fasta scores; opt: 266 z-score: 448.4 E(): 1.2e-17, 91.1% identity in 45 aa overlap. Contains Pfam match to entry PF00468 Ribosomal_L34, Ribosomal protein L34, score 75.20, E-value 1.2e-20 and PS00784 Ribosomal protein L34 signature; Belongs to the bacterial ribosomal protein bL34 family.
  
  
 0.976
SCO5586
Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily.
   
 0.976
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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