STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO3889Thioredoxin; Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Stimulates complex formation between sigma factor SigR and its cognate anti-sigma factor RsrA probably by reducing RsrA. (110 aa)    
Predicted Functional Partners:
SCO3890
SCH24.12c, trxB, thioredoxin reductase (NADPH), len: 322 aa; previously sequenced as SW:TRXB_STRCO (EMBL:AJ007313), TrxB. Contains PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site; Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
 
 0.994
SCO6834
Putative thioredoxin reductase; SC3D9.02c, trxB2, possible thioredoxin reductase (326 aa). Previously sequenced and consequently identical to Streptomyces coelicolor TR:CAB61258 (EMBL:AJ251005). Also highly similar to the other Streptomyces coelicolor trxB CDS: SW:TRXB_STRCO(EMBL:X92105) thioredoxin reductase (EC 1.6.4.5) SCH24.12 (321 aa), fasta scores opt: 1547 z-score: 1709.6 E():0 74.2% identity in 310 aa overlap. Contains a Prosite hit to PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site.
 
 0.929
SCO7298
Putative thioredoxin reductase; SC5F8.08c, possible thioredoxin reductase, len: 558 aa. The C-terminus of this protein is highly similar to many thioredoxin reductases including: Streptomyces clavuligerus SW:TRXB_STRCL(EMBL:Z21946) thioredoxin reductase (EC 1.6.4.5) (321 aa), fasta scores opt: 494 z-score: 519.8 E(): 1.7e-21 32.8% identity in 332 aa overlap. The N-terminus is similar to the receiver domains of many response regulators e.g. Alcaligenes eutrophus SW:HOXA_ALCEU(EMBL:M64593) hydrogenase transcriptional regulatory protein, HoxA (482 aa) (32% identity over a 117 aa overlap). [...]
 
 
 0.918
SCO3892
SCH24.14c, sigT, probable RNA polymerase sigma factor, len: 236 aa; previously sequenced as TR:O86856 (EMBL:AJ007313), SigT. Similar to other S.coelicolor putative sigma factors TR:O54163 (EMBL:AL021411) possible sigma factor (200 aa) (32.2% identity in 199 aa overlap) and SCH10.35 putative RNA polymerase sigma factor from cosmid StH10 (294 aa) (37.7% identity in 159 aa overlap). Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily), score 57.10, E-value 3.8e-13.
     
 0.771
SCO3893
SCH24.15c, hypothetical protein, len: 563 aa; unknown function, previously partially sequenced as TR:O86855 (EMBL:AJ007313) Streptomyces coelicolor hypothetical protein (281 aa). Weakly similar to TR:Q53839 (EMBL:U19250) Streptomyces coelicolor protein kinase-like protein (565 aa), fasta scores; opt: 205 z-score: 204.5 E(): 0.00045, 25.1% identity in 263 aa overlap and to C-terminal half of TR:O05435 (EMBL:Z94121) Mycobacterium tuberculosis hypothetical protein (1184 aa) (26.9% identity in 557 aa overlap).
  
    0.707
SCO2026
SC3A3.04c, gltB, probable glutamate synthase large subunit, len: 1514 aa; similar to bacterial glutamate synthases e.g. TR:Q51583 (EMBL:D85230), gltB, Plectonema boryanum large subunit of NADH-dependent glutamate synthase (1530 aa), fasta scores; opt: 5662 z-score: 6172.3 E(): 0, 56.4% identity in 1518 aa overlap. Also similar to part of eukaryotic glutamate synthases e.g. SW:GLSN_MEDSA (EMBL:L01660) Medicago sativa (Alfalfa) Glutamate synthase [NADH] precursor (2194 aa) (49.9% identity in 1577 aa overlap).
   
 
 0.687
SCO3671
Heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 
 0.648
SCO4919
SCK13.11, probable oxidoreductase, len: 475 aa; similar to SW:DLD2_BACSU (EMBL:D84432) Bacillus subtilis dihydrolipoamide dehydrogenase (EC 1.8.1.4) BfmBC, 474 aa; fasta scores: opt: 753 z-score: 813.4 E(): 0; 29.9% identity in 472 aa overlap. Contains Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase.
  
 
 0.587
SCO3894
SCH24.16c, probable transmembrane protein, len: 811 aa; unknown function, similar to hypothetical proteins e.g. the N-terminal half of TR:O05435 (EMBL:Z94121) Mycobacterium tuberculosis hypothetical protein (1184 aa), fasta scores; opt: 573 z-score: 440.2 E(): 3.4e-17, 31.1% identity in 573 aa overlap and TR:Q50198 (EMBL:L39923) Mycobacterium leprae hypothetical protein (379 aa) (31.7% identity in 398 aa overlap). Also weakly similar to SW:MVIN_SALTY (EMBL:Z26133) Salmonella typhimurium 'mvin' (524 aa) (26.8% identity in 456 aa overlap). The N-terminal third is hydrophilic, while the r [...]
       0.567
SCO2901
SCE19A.01, hypothetical protein, partial CDS, len: >31 aa; unknown function, similar to members of the alkyl hydroperoxide reductase C/thiol-specific antioxidant family e.g. TR:O53226 (EMBL:AL021185), bcp, Mycobacterium tuberculosis bacterioferritin comigratory protein (157 aa), fasta scores; opt: 124 z-score: 238.1 E(): 6.2e-06, 63.3% identity in 30 aa overlap; SCE6.38, unknown, len: 155 aa. Highly similar to many bacterioferritin co migratory proteins which have no known function e.g. Escherichia coli SW:BCP_ECOLI(EMBL:M63654) bacterioferritin co migratory protein, Bcp (156 aa), fast [...]
  
 
 0.562
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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