STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3894SCH24.16c, probable transmembrane protein, len: 811 aa; unknown function, similar to hypothetical proteins e.g. the N-terminal half of TR:O05435 (EMBL:Z94121) Mycobacterium tuberculosis hypothetical protein (1184 aa), fasta scores; opt: 573 z-score: 440.2 E(): 3.4e-17, 31.1% identity in 573 aa overlap and TR:Q50198 (EMBL:L39923) Mycobacterium leprae hypothetical protein (379 aa) (31.7% identity in 398 aa overlap). Also weakly similar to SW:MVIN_SALTY (EMBL:Z26133) Salmonella typhimurium 'mvin' (524 aa) (26.8% identity in 456 aa overlap). The N-terminal third is hydrophilic, while the r [...] (811 aa)    
Predicted Functional Partners:
SCO3843
Hypothetical protein; SCH69.13, unknown, len: 290 aa; similar to the N-terminal region of TR:P71590 (EMBL:Z80233) hypothetical protein from Mycobacterium tuberculosis (527 aa) fasta scores; opt: 268, z-score: 221.4, E(): 5.3e-05, (28.1% identity in 217 aa overlap).
  
 
 
 0.960
SCO3895
SCH24.17c, putative membrane protein, len: 787 aa; unknown function, probable CDS suggested by positional base preference, GC frame analysis and amino acid composition. Contains possible hydrophobic membrane spanning regions.
 
   
 0.850
SCO3896
SCH24.18, probable RNA nucleotidyltransferase, len: 483 aa; similar to tRNA nucleotidyltransferases e.g. SW:CCA_ECOLI (EMBL:M12788), cca, Escherichia coli tRNA nucleotidyltransferase (412 aa), fasta scores; opt: 413 z-score: 480.7 E(): 1.8e-19, 33.8% identity in 334 aa overlap. Also similar to mRNA poly(A) polymerases e.g. SW:PCNB_ECOLI (EMBL:S48039), pcnB, Escherichia coli poly(A) polymerase (472 aa) (32.0% identity in 256 aa overlap). Contains probable coiled-coil from 392 to 425 (34 residues) (Max score: 1.525, probability 0.97); Belongs to the tRNA nucleotidyltransferase/poly(A) po [...]
       0.725
SCO3893
SCH24.15c, hypothetical protein, len: 563 aa; unknown function, previously partially sequenced as TR:O86855 (EMBL:AJ007313) Streptomyces coelicolor hypothetical protein (281 aa). Weakly similar to TR:Q53839 (EMBL:U19250) Streptomyces coelicolor protein kinase-like protein (565 aa), fasta scores; opt: 205 z-score: 204.5 E(): 0.00045, 25.1% identity in 263 aa overlap and to C-terminal half of TR:O05435 (EMBL:Z94121) Mycobacterium tuberculosis hypothetical protein (1184 aa) (26.9% identity in 557 aa overlap).
 
    0.715
SCO3846
SCH69.16, probable FtsW/RodA/SpoVE family cell cycle protein, len: 479aa; similar to many egs. SW:FTSW_MYCTU probable cell division protein FtsW from Mycobacterium tuberculosis (469 aa) fasta scores; opt: 1367, z-score: 1568.6, E(): 0, (48.8% identity in 451 aa overlap) and SW:SP5E_BACSU stage V sporulation protein E from Bacillus subtilis (366 aa) fasta scores; opt: 496, z-score: 572.9, E(): 1.4e-24, (31.7% identity in 391 aa overlap). Also similar to SC6G9.31 from Streptomyces coelicolor (446 aa) fasta scores; opt: 1132, z-score: 1182.0, E(): 0, (58.6% identity in 444 aa overlap). Co [...]
 
  
 0.657
SCO5302
SC6G9.31, probable integral membrane cell-cycle protein, len: 446 aa; similar to members of the ftsW (Escherichia coli cell division)/rodA (Escherichia coli cell shape)/spoVE (Bacillus subtilis spore formation) family e.g. SW:SP5E_BACSU (EMBL:X51419), spoVE, Bacillus subtilis stage V sporulation protein E (366 aa), fasta scores; opt: 461 z-score: 525.9 E(): 5.8e-22, 33.4% identity in 371 aa overlap. Highly similar to proteins from mycobacteria e.g. TR:FTSW_MYCLE (EMBL:Z70722), ftsW, Mycobacterium leprae probable cell division protein (465 aa) (46.5% identity in 430 aa overlap). Contain [...]
 
  
 0.620
SCO3892
SCH24.14c, sigT, probable RNA polymerase sigma factor, len: 236 aa; previously sequenced as TR:O86856 (EMBL:AJ007313), SigT. Similar to other S.coelicolor putative sigma factors TR:O54163 (EMBL:AL021411) possible sigma factor (200 aa) (32.2% identity in 199 aa overlap) and SCH10.35 putative RNA polymerase sigma factor from cosmid StH10 (294 aa) (37.7% identity in 159 aa overlap). Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily), score 57.10, E-value 3.8e-13.
       0.597
SCO2090
SC4A10.23c, ftsI, cell division protein, len: 654 aa; previously sequenced as TR:Q9Z5V7 (EMBL:AF123319), FtsI, Streptomyces coelicolor cell division protein (651 aa) and identical to that sequence, but with a different putative start codon. C-terminal end shares weak similarity with others from S.coelicolor e.g. SC6G9.32 (EMBL:AL079356) S.coelicolor possible penicillin-binding protein (485 aa) (29.3% identity in 447 aa overlap). Contains a hydrophobic, possible membrane-spanning region. Contains Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domai [...]
  
   
 0.591
SCO1384
SC1A8A.04c, hypothetical protein, len: 267aa; similar to but longer than SW:Q50606 (Y0DG_MYCTU) hypothetical protein from Mycobacterium tuberculosis (162 aa) fasta scores; opt: 503, z-score: 488.2, E(): 9.2e-20, 56.0% identity in 141 aa overlap. Contains Pfam match to entry PF00498 FHA, FHA domain.
  
 
 
 0.584
SCO2709
SCC61A.30, possible integral membrane protein, len: 523aa; similar to many proposed virulence factors eg. SW:P37169 (MVIN_SALTY) virulence factor MviN from Salmonella typhimurium (524 aa) fasta scores; opt: 475, z-score: 495.1, E(): 4e-20, 28.8% identity in 423 aa overlap. Contains possible hydrophobic membrane spanning regions.
  
     0.569
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (26%) [HD]