STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3907SCH24.29, ssb, probable single-strand DNA-binding protein, len: 199 aa; similar to SW:SSB_SERMA (EMBL:X65080), Ssb, Serratia marcescens single-strand binding protein (175 aa), fasta scores; opt: 278 z-score: 245.3 E(): 2.4e-06, 33.3% identity in 168 aa overlap. C-terminus contains glycine-rich repeats similar to those found in eukaryotic RNA-binding proteins e.g. SW:GRP2_SINAL (EMBL:L31377), Grp2A, Sinapis alba (white mustard) glycine-rich RNA-binding protein (169 aa). Contains Pfam match to entry PF00436 SSB, Single-strand binding protein family, score 143.30, E-value 2.5e-39. (199 aa)    
Predicted Functional Partners:
SCO3906
Putative 30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA.
 
  
 0.976
SCO3909
50S ribosomal protein L9; Binds to the 23S rRNA.
  
  
 0.948
SCO2683
SCC61A.04c, possible single-strand DNA-binding protein, len: 156 aa; similar to many eg. SW:P71711 (SSB_MYCTU) single-strand binding protein from Mycobacterium tuberculosis (164 aa) fasta scores; opt: 259, z-score: 301.8, E(): 2.4e-09, 35.5% identity in 141 aa overlap and TR:Q9X8U3 (EMBL:AL049826) putative single-strand binding protein from Streptomyces coelicolor (199 aa) fasta scores; opt: 261, z-score: 302.7, E(): 2.1e-09, 42.5% identity in 120 aa overlap. Contains Pfam match to entry PF00436 SSB, Single-strand binding protein family.
  
  
0.928
SCO1475
Putative primosomal protein n; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily.
 
 
 
 0.920
SCO3541
SCH5.03c, possible DNA polymerase, len: 401 aa; limited region of similarity to many DNA polymerase III subunits e.g. SW:DP3X_SALTY DNA polymerase III subunits gamma and tau from Salmonella typhimurium (642 aa) fasta scores; opt: 327, z-score: 338.5, E(): 1.5e-11, (32.1% identity in 246 aa overlap). Contains probable coiled-coil region from 245 to 285 (41 residues), max score: 1.601, (probability 0.99).
 
 
 
 0.910
SCO4067
DNA polymerase III subunit gamma; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
 
 
 
 0.899
SCO3908
Putative 30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family.
  
  
 0.897
SCO2064
DNA polymerase III alpha chain; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily.
 
 
 
 0.885
dnaE
SCP1.224c, dnaE, probable DNA polymerase III, alpha chain (EC 2.7.7.7), len: 1213aa; similar to many eg. SW:Q10779 (DP3A_MYCTU) probable DNA polymerase III, alpha chain from Mycobacterium tuberculosis (1184 aa) fasta scores; opt: 3067, z-score: 3382.7, E(): 0, 55.8% identity in 1200 aa overlap and SW:P10443 (DP3A_ECOLI) DNA polymerase III, alpha chain (EC 2.7.7.7) from Escherichia coli (1160 aa) fasta scores; opt: 845, z-score: 927.5, E(): 0, 36.2% identity in 1178 aa overlap. Contains Pfam match to entry PF02231 PHP_N, PHP domain N-terminal region.
 
 
 
 0.880
SCO2299
SCC30.07c, possible bifunctional protein (ribonuclease H/phosphoglycerate mutase), len: 497 aa; N-terminal region similar to TR:Q9X7R6 (EMBL:AL049863) Streptomyces coelicolor putative ribonuclease H SC5H1.08c, 235 aa; blastp scores: Score = 185 (65.1 bits), Expect = 9.5e-14, P = 9.5e-14 Identities = 82/230 (35%), Positives = 105/230 (45%) and C-terminal region similar to TR:O67797 (EMBL:AE000766) Aquifex aeolicus phosphoglycerate mutase PgmA, 212 aa; fasta scores: opt: 355 z-score: 327.3 E(): 8.7e-11; 32.8% identity in 201 aa overlap. Contains Pfam match to entry PF00075 rnaseH, RNase [...]
 
 
 
 0.868
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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