STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3910SCH24.32c, putative membrane protein, len: 448 aa; similar to many e.g. SW:DINF_ECOLI (EMBL:L02362), DinF, Escherichia coli DNA-damage-inducible protein (459 aa), fasta scores; opt: 571 z-score: 655.4 E(): 3.4e-29, 30.0% identity in 437 aa overlap. There is an alternative start codon at the third amino acid. Contains possible hydrophobic membrane spanning regions. (448 aa)    
Predicted Functional Partners:
SCP1.212
Putative bifunctional undecaprenyl pyrophosphate synthetase/phytoene synthase; Catalyzes the reaction from prephytoene diphosphate to phytoene; In the N-terminal section; belongs to the phytoene/squalene synthase family.
  
 
 0.754
SCO1998
SC7H2.12c, rpsA, 30S ribosomal protein S1, len: 502aa; similar to many eg. SW:RS1_ECOLI rpsA, 30S ribosomal protein S1 from Escherichia coli (557 aa) fasta scores; opt: 1016, z-score: 1019.6, E(): 0, (39.8% identity in 452 aa overlap). Also similar to TR:O06147 (EMBL:Z95554) 30S ribosomal protein S1 from Mycobacterium tuberculosis (481 aa) fasta scores; opt: 2420, z-score: 2422.2, E(): 0, (79.1% identity in 492 aa overlap). Contains four Pfam matches to entry PF00575 S1, S1 RNA binding domain. Also contains possible coiled-coil region around 400-410aa.
  
    0.721
SCO3676
SCH35.48c, possible integral membrane protein, len: 350aa; Contains possible membrane spanning hydrophobic regions in the C-terminal half and a hydrophobic N-terminal half.
  
    0.721
SCO0187
SCJ1.36, crtI, probable phytoene synthase, len: 331 aa. Shares a high level of similarity with Streptomyces griseus SW:CRTB_STRGR (EMBL; L37405) phytoene synthase (342 aa), fasta scores opt: 1388 z-score: 1657.5 E(): 0 67.6% identity in 343 aa overlap and Mycobacterium marinum TR: O05423 (EMBL; U92075) phytoene synthase (319 aa), fasta scores opt: 996 z-score: 1191.5 E():0 52.2% identity in 316 aa overlap. Contains a PS01045 Squalene and phytoene synthases signature 2 and a Pfam match to entry PF00494 SQS_PSY, Squalene and phytoene synthases.
   
 
 0.710
SCO6759
SC6A5.08, probable phytoene synthase, len: 303aa; similar to many eg. TR:Q50892 (EMBL:Z21955) phytoene synthase from the light-induced carotenoid biosynthesis cluster of Myxococcus xanthus (336 aa) fasta scores; opt: 322, z-score: 379.7, E(): 7.5e-14, (31.8% identity in 274 aa overlap). Contains Pfam match to entry PF00494 SQS_PSY, Squalene and phytoene synthases, score 34.70, E-value 1.2e-08.
   
 
 0.710
SCO6760
SC6A5.09, probable phytoene synthase, len: 312aa; similar to many egs. SW:CRTB_MYCTU probable phytoene synthase from Mycobacterium tuberculosis (302 aa) fasta scores; opt: 791, z-score: 925.6, E(): 0, (48.3% identity in 286 aa overlap) and SW:PSY_ARATH phytoene synthase precusor from Arabidopsis thaliana (mouse ear cress) (423 aa) fasta scores; opt: 493, z-score: 577.3, E(): 7.4e-25, (34.4% identity in 282 aa overlap). Contains Pfam match to entry PF00494 SQS_PSY, Squalene and phytoene synthases, score 168.70, E-value 9.4e-47 and Prosite matches to PS01044 Squalene and phytoene synthas [...]
   
 
 0.710
SCO1947
Glyceraldehyde-3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-phosphate dehydrogenase [...]
  
  
 0.665
SCO7040
SC4G1.06c, gap2, glyceraldehyde-3-phosphate dehydrogenase, len: 481 aa; highly similar to TR:O68923 (EMBL:AF058302) Streptomyces roseofulvus glyceraldehyde-3-phosphate dehydrogenase homolog GapX, 461 aa; fasta scores: opt: 2562 z-score: 2921.8 E(): 0; 84.5% identity in 459 aa overlap and to many eukaryotic homologos, e.g. SW:G3PA_MAIZE (EMBL:X15408) Zea mays glyceraldehyde-3-phosphate dehydrogenase A, chloroplast precursor (EC 1.2.1.12) GapA, 403 aa; fasta scores: opt: 793 z-score: 907.5 E(): 0; 39.6% identity in 366 aa overlap. Contains Pfam match to entry PF00044 gpdh, glyceraldehyde [...]
  
  
 0.665
SCO7511
SCBAC25F8.03, gap2, glyceraldehyde 3-phosphate dehydrogenase, len: 332 aa; highly similar to SW:G3P_STRAU (EMBL:U21191) Streptomyces aureofaciens glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12) Gap, 332 aa; fasta scores: opt: 1898 Z-score: 2070.6 bits: 391.5 E(): 1e-107; 88.855% identity in 332 aa overlap and to TR:CAB38137 (EMBL:AL035591) Streptomyces coelicolor glyceraldehyde 3-phosphate dehydrogenase Gap or SCC54.07c, 337 aa; fasta scores: opt: 1272 Z-score: 1174.4 bits: 225.7 E(): 1.1e-59; 57.831% identity in 332 aa overlap. Contains Pfam matches to entries PF00044 gpdh, Gly [...]
  
  
 0.665
SCO5705
SC5H4.29, hypothetical protein, len: 101 aa; similar to SW:YLXR_BACSU (EMBL:Z18631) Bacillus subtilis hypothetical 10.4 kD protein in NusA-InfB intergenic region (ORF3) YlxR, 91 aa; fasta scores: opt: 130 z-score: 176.4 E(): 0.023; 29.7% identity in 91 aa overlap. Contains and match to Prosite entry.
   
 
 0.604
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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