STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3927SCQ11.10c, possible membrane protein, len: 513 aa; unknown function, probable CDS with Pro/Arg-rich N-terminus and 4x degenerate GGGHGA repeats from aa 58-81. Contains hydrophobic, possible membrane-spanning regions. (513 aa)    
Predicted Functional Partners:
SCO1051
SCG20A.31, possible integral membrane protein, len: 357 aa; similar to TR:Q9S290 (EMBL:AL096849) Streptomyces coelicolor putative membrane protein SCI11.29, 354 aa; fasta scores: opt: 422 z-score: 473.8 E(): 6.5e-19; 30.5% identity in 357 aa overlap.
     
 0.869
SCO4045
2SCD60.11c, possible integral membrane protein, len: 226 aa; similar to TR:O06141 (EMBL:Z95554) Mycobacterium tuberculosis hypothetical 20.4 kDa protein MTCY01B2.16c, 195 aa; fasta scores: opt: 628 z-score: 680.7 E(): 2.4e-30; 50.8% identity in 191 aa overlap. Contains possible hydrophobic membrane spanning regions.
      
 0.850
SCO7316
SC5F8.26, possible integral membrane protein, len: 280 aa. Similar to Bacillus subtilis SW:YXXB_BACSU(EMBL:D45912) hypothetical 31.8 kd protein (289 aa), fasta scores opt: 476 z-score: 539.7 E(): 1.4e-22 31.0% identity in 245 aa overlap. Contains multiple possible membrane spanning hydrophobic domains.
      
 0.850
SCO3928
Putative thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
       0.747
SCO3837
SCH69.07c, putative membrane protein, len: 436 aa. Contains possible hydrophobic membrane spanning regions.
  
   
 0.596
SCO2712
SCC61A.33, possible membrane protein, len: 239aa; weakly similar to TR:Q9X4U6 (EMBL:AF118389) from cps locus of Streptococcus suis serotype 2 (229 aa) fasta scores; opt: 161, z-score: 172.0, E(): 0.04, 28.4% identity in 176 aa overlap. Contains possible membrane-spanning hydrophobic regions.
  
   
 0.572
SCO4329
SCD12A.12c, possible integral membrane protein, len: 463 aa; similar to TR:Q9X8T4 (EMBL:AL049826) Streptomyces coelicolor putative membrane protein SCH24.20c, 425 aa; fasta scores: opt: 305 z-score: 344.1 E(): 1.1e-11; 28.7% identity in 411 aa overlap. Contains possible hidrophobic membrane spanning regions.
  
   
 0.571
SCO7660
Voltage-gated potassium channel; Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel.
  
   
 0.567
SCO2026
SC3A3.04c, gltB, probable glutamate synthase large subunit, len: 1514 aa; similar to bacterial glutamate synthases e.g. TR:Q51583 (EMBL:D85230), gltB, Plectonema boryanum large subunit of NADH-dependent glutamate synthase (1530 aa), fasta scores; opt: 5662 z-score: 6172.3 E(): 0, 56.4% identity in 1518 aa overlap. Also similar to part of eukaryotic glutamate synthases e.g. SW:GLSN_MEDSA (EMBL:L01660) Medicago sativa (Alfalfa) Glutamate synthase [NADH] precursor (2194 aa) (49.9% identity in 1577 aa overlap).
       0.560
SCO2070
SC4A10.03, possible membrane protein, len: 382 aa; unknown function, shows weak similarity to parts of many hypothetical proteins e.g. SW:YB43_METJA (EMBL:U67556) Methanococcus jannaschii hypothetical protein (361 aa), fasta scores; opt: 222 z-score: 255.3 E(): 6.7e-07, 24.8% identity in 306 aa overlap. Contains hydrophobic, possible membrane-spanning regions. Contains Pfam match to entry PF00924 UPF0003, Uncharacterized protein family UPF0003.
      
 0.499
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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