STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3956SCD78.23, putative ABC transporter ATP-binding protein, similar to YHCH_BACSU (EMBL:X96983) hypothetical ABC transporter ATP-binding protein from Bacillus subtilis, fasta scores; opt: 438, z-score: 522.7, E(): 7.2e-22, (33.6% identity in 220 aa overlap) and YHIH_ECOLI (EMBL:U00039) ABC transporter ATP-binding protein from Escherichia coli fasta scores; opt: 445, z-score: 530.5, E(): 2.6e-22, (30.7% identity in 287 aa overlap). Contains Pfam match to entry PF00005 ABC_tran, ABC transporters, score 183.40, E-value 3.8e-51 and PS00017 ATP /GTP-binding site motif A (P-loop). (320 aa)    
Predicted Functional Partners:
SCO3957
SCD78.24, possible integral membrane protein, len: 293 aa, possible membrane spanning hydrophobic regions.
 
 
 0.975
SCO3959
SCD78.26, possible integral membrane protein, len: 239 aa, possible membrane spanning regions.
 
 
 0.974
SCO3958
SCD78.25, ABC transporter ATP-binding protein, len: 303 aa; similar to TR:Q45404 (EMBL:U09819) SpaFABC transporter ATP-binding protein (247 aa) from Bacillus subtilis, fasta scores;opt: 524, z-score: 615.6, E(): 4.8e-27, (39.3% identity in 234 aa overlap). Contains Pfam match to entry PF00005 ABC_tran, ABC transporters, score 161.50, E-value 1.4e-44 and Prosite matches to PS00017 ATP.
 
   
0.908
SCO3954
SCD78.21c, putative oxidoreductase, len: 584 aa; N-terminal region similar to Y00P_MYCTU (EMBL:Z70283) putative oxidoreductase from Mycobacterium tuberculosis (650 aa), fasta scores; opt: 1457, z-score: 840.1, E(): 0, 41.0% identity in 652 aa overlap. Contains PS00061 short chain dehydrogenases /reductases family signature.
       0.776
SCO3951
Hypothetical protein SCD78.18c; SCD78.18c, unknown, len: 320 aa; similarity to TR:Q54379 (EMBL:X79146) LmbY(295 aa), part of a gene cluster involved in lincomycin biosynthesis /resistance in Streptomyces lincolnensis, fasta scores; opt: 814, z-score: 584.1, E(): 2.8e-25, (43.8% identity in 290 aa overlap). Also similar to TR:Q49598 (EMBL:U31567) F420-dependent N5,N10-methylenetetrahydromethanopterin reductase from Methanopyruskandleri fasta scores; opt: 191, z-score: 333.9, E(): 2.5e-11, (29.1% identity in 247 aa overlap).
       0.715
SCO3952
Hypothetical protein SCD78.19c; SCD78.19c, unknown, len: 152 aa.
       0.715
SCO3953
Possible phosphotransferase; Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''- cyclic phosphate (APPR>P). May function as an ADP-ribosylase (By similarity).
       0.715
SCO3950
SCD78.17c, conserved hypothetical protein, len: 308 aa; similar to e.g. TR:O07810 (EMBL:Z97188) from Mycobacterium tuberculosis fasta scores; opt: 503, z-score: 626.7, E(): 1.2e-27, (37.9% identity in 277 aa overlap) and YIDA_ECOLI (EMBL:L10328) Escherichia coli fasta scores; opt: 297, z-score: 407.5, E(): 1.9e-15, (31.6% identity in 282 aa overlap). Also similar to SCD78.27c, approx 9kb upstream (37.9% identity in 285 aa overlap). Contains Pfam match to entry PF00592 DUF3, Domain of Unknown Function 3, score 99.00, E-value 9.5e-26.
  
   0.710
SCO4688
SCD31.13c, hypothetical protein, len: 118 aa; highly similar to TR:O54113 (EMBL:AL021529) Streptomyces coelicolor hypothetical 12.6 kD protein SC10A5.22, 112 aa; fasta scores: opt: 579 z-score: 753.8 E(): 0; 87.0% identity in 100 aa overlap.
      
 0.649
SCO3328
SCE68.26c, hypothetical protein, len: 70 aa; similar to TR:Q49828 (EMBL:U00018) Mycobacterium leprae hypothetical protein (86 aa), fasta scores; opt: 269 z-score: 380.5 E(): 7.2e-14, 68.3% identity in 63 aa overlap. Weakly similar to putative excisionases e.g. TR:Q54076 (EMBL:L11597), xis, Saccharopolyspora erythraea excisionase (76 aa) (34.0% identity in 47 aa overlap) and SCE29.20c (EMBL:AL035707) S.coelicolor probable excisionase (66 aa) (33.3% identity in 48 aa overlap). Contains probable helix-turn-helix motif at aa 16-37 (Score 1251, +3.45 SD).
      
 0.646
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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