STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO3978SCBAC25E3.15c, possible oxidoreductase, len: 294aa: similar to many eg. TR:Q53929 (EMBL:X62373) ORF 4 from the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor (306 aa) fasta scores; opt: 624, Z-score: 633.9, 40.199% identity (41.581% ungapped) in 301 aa overlap. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases and Prosite match to PS01162 Quinone oxidoreductase / zeta-crystallin signature. (294 aa)    
Predicted Functional Partners:
SCO3979
SCBAC25E3.16, possible TetR-family transcriptional regulator, len: 196 aa: similar to many from Streptomyces coelicolor e.g. TR:Q9RK21 (EMBL:AL109974) putative TetR-family transcriptional regulator SCF34.04 (203 aa) fasta scores; opt: 497, Z-score: 587.5, 43.750% identity (44.681% ungapped) in 192 aa overlap. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family.
 
   
 0.793
SCO7060
SC4G1.26c, conserved hypothetical protein, len: 201 aa; similar to TR:Q9S2N1 (EMBL:AL109661) Streptomyces coelicolor hypothetical 24.3 kDa protein SC6E10.06c, 215 aa; fasta scores: opt: 540 z-score: 638.3 E(): 4.4e-28; 42.9% identity in 198 aa overlap.
     
 0.563
SCO5928
Hypothetical protein; SC10A5.33c, unknown, len: 234 aa.
       0.560
SCO7059
SC4G1.25c, possible oxidoreductase, len: 233 aa; similar to TR:Q51492 (EMBL:D84146) Pseudomonas aeruginosa reductase PahA, 328 aa; fasta scores: opt: 297 z-score: 346.1 E(): 8.3e-12; 32.0% identity in 203 aa overlap.
       0.560
SCO7302
SC5F8.12c, hypothetical protein, len: 210 aa; similar to TR:AAK45279 (EMBL:AE006986) Mycobacterium tuberculosis CDC1551 hypothetical protein MT1029, 205 aa; fasta scores: opt: 784 Z-score: 926.8 E(): 5.5e-44; 56.796% identity in 206 aa overlap.
  
  
 0.501
SCO1220
2SCG58.20c, probable regulatory protein, len: 253 aa; similar to SW:ALGR_PSEAE (EMBL:M23230) Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, 248 aa; fasta scores: opt: 384 z-score: 457.3 E(): 5.3e-18; 36.5% identity in 255 aa overlap. Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain.
      
 0.483
SCO2055
Hypothetical protein; SC4G6.24, unknown, len: 525 aa; previously sequenced but annotated as two seperate hypothetical CDSs TR:Q53930 and TR:Q53931 (EMBL:X64420)) suggesting a sequence error which lead to a frameshift. Amino acid and codon usage plots support a single CDS. Also similar to TR:O88013 (EMBL:AL031107) hypothetical protein from Streptomyces coelicolor (527 aa) fasta scores; opt: 593, z-score: 699.2, E(): 1.3e-31, (36.0% identity in 545 aa overlap). Contains possible hydrophobic membrane spanning region at C-terminal domain.
      
 0.483
SCO5864
Conserved hypothetical protein; SC2E9.05, unknown, len: 98 aa; highly similar to hypothetical proteins from Mycobacterium tuberculosis and M. leprae eg. TR:O07201 (EMBL:Z96072) MTCY05A6.20C (100 aa), fasta scores; opt: 465 z-score: 814.5 E(): 0, 71.4% identity in 98 aa overlap.
      
 0.483
SCO2054
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
      
 0.412
SCO3943
SCD78.10c, probable transcriptional regulator, len: 370 aa; identical to TR:G3644044 (EMBL:AF090833) putative transcriptional regulator (RstP) from Streptomyces coelicolor. Also similar to members of the lacI family of transcriptional regulators e.g. PURR_ECOLI ((EMBL:J04212)(fasta scores; opt: 345, z-score: 356.4, E(): 1.3e-12, 28.2% identity in 347 aa overlap) purine nucleotide synthesis repressor from Escherichia coli. Contains PS00356 Bacterial regulatory proteins, lacI family signature and Pfam match to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and LacI family, s [...]
      
 0.412
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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