STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO4008Putative tetR family regulatory protein; Probably regulates the expression of its own gene and the adjacent SCO4007 gene by binding to two operator sites in the SCO4007- SCO4008 intergenic region. (192 aa)    
Predicted Functional Partners:
SCO4007
2SC10A7.11c, possible integral membrane protein, len: 430 aa; similar to TR:P96675 (EMBL:AB001488) Bacillus subtilis YdeR protein, 395 aa; fasta scores: opt: 611 z-score: 612.1 E(): 1.4e-26; 31.4% identity in 373 aa overlap. Contains possible hydrophobic membrane spanning regions; Belongs to the major facilitator superfamily.
 
   
 0.864
SCO2900
Putative membrane protein; SCE6.37c, possible membrane protein, len: 110 aa. Contains a possible membrane spanning hydrophobic domain.
      
 0.646
SCO7133
SC4B10.34, possible membrane protein, len: 113 aa; similar to TR:CAB89768 (EMBL:AL354616) Streptomyces coelicolor putative membrane protein SC3A4.22, 114 aa; fasta scores: opt: 276 z-score: 371.5 E(): 3.1e-13; 39.4% identity in 109 aa overlap. Contains possible hydrophobic membrane spanning region.
      
 0.646
SCO2973
SCE59.32c, pkaB, serine/threonine protein kinase (partial), len: >233 aa; identical to C-terminal region of previously sequenced SW:PKAB_STRCO (EMBL:D86821) Streptomyces coelicolor serine/threonine protein kinase PkaB, 417 aa. Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain. Contains possible hydrophobic membrane spanning region; SCE50.01, pkaB, serine/threonine protein kinase (fragment), len: >222 aa; identical to C-terminal region of previously sequenced SW:PKAB_STRCO (EMBL:D86821) Streptomyces coelicolor serine/threonine protein kinase PkaB (EC 2.7.1.- [...]
      
 0.515
SCO0062
SCJ4.43c, probable LacI family transcriptional regulator, len: 367 aa; similar to many transcriptional regulators e.g. SW:GALR_ECOLI galactose operon repressor (343 aa) fasta scores; opt: 549, z-score: 636.2, E(): 4.5e-28, (32.5% identity in 332 aa overlap). Contains Pfam matches to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and LacI family and entry PF00356 lacI, Bacterial regulatory proteins, lacI family. Contains possible helix-turn-helix motif (+3.86 SD) 26-47.
      
 0.469
SCO0940
SCM10.28, possible marR-family regulatory protein, len: 157 aa; weakly similar to TR:O07458 (EMBL:U75363) Rhodopseudomonas palustris putative regulatory protein, 175 aa; fasta scores: opt: 150 z-score: 189.7 E(): 0.0036; 28.1% identity in 160 aa overlap. Contains Pfam match to entry PF01047 MarR, MarR family.
      
 0.469
SCO2105
SC2C1A.01c, possible transcriptional regulatory protein, partial CDS, len: > 57 aa. Similar to Mycobacterium tuberculosis TR:O53509 (EMBL:AL021957) hypothetical protein (146 aa), fasta scores opt: 137 z-score: 204.5 E(): 0.00048 42.3% identity in 71 aa overlap. Overlaps and extends into CDS SC4A10.38c on the adjoining cosmid. Contains a putative helix-turn-helix motif situated between residues 17..38 (+4.08 SD); SC4A10.38c, conserved hypothetical protein, partial CDS, len: >86 aa; similar to mycobacterial hypothetical proteins TR:O53509 (EMBL:AL021957) Mycobacterium tuberculosis hypoth [...]
   
  
 0.469
SCO4313
SCD95A.46, possible regulatory protein, len: 216 aa; similar to TR:CAB56658 (EMBL:AL121596) Streptomyces coelicolor putative tetR family transcriptional regulator SCF51A.06, 177 aa; fasta scores: opt: 164 z-score: 202.9 E(): 0.00077; 32.0% identity in 103 aa overlap. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family and possible helix-turn-helix motif at residues 37..58 (+5.35 SD).
      
 0.469
SCO4639
SCD82.10, hypothetical protein, len: 201 aa; similar to TR:CAB52009 (EMBL:AL109663) Streptomyces coelicolor putative transcriptional regulator SC4A10.33, 209 aa; fasta scores: opt: 138 z-score: 174.2 E(): 0.028; 30.3% identity in 165 aa overlap.
      
 0.469
SCO5017
SCK15.19, possible araC family regulatory protein, len: 365 aa; similar to TR:Q54308 (EMBL:X86780) Streptomyces hygroscopicus helix-turn-helix DNA-binding protein, 330 aa; fasta scores: opt: 247 z-score: 294.6 E(): 6.1e-09; 28.6% identity in 346 aa overlap. Contains fam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family and match to Prosite entry PS00041 Bacterial regulatory proteins, araC family signature. Contains also a TTA leucine codon, possible target for bldA regulation.
      
 0.469
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.