STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
SCO4035RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is required for normal spore maturation. (287 aa)    
Predicted Functional Partners:
SCO5244
2SC7G11.06c, prs1, anti-sigma factor, len: 137 aa; identical to previously sequenced TR:Q9R3X8 (EMBL:AJ249450) Streptomyces coelicolor A3(2) putative regulator of Sig1, Prs1 protein or UshX, 137 aa.
 
 
 0.850
SCO5747
SC7C7.02c, possible regulatory protein, len: 916 aa; N-terminus is similar to S. coloicolor TR:Q53897 (EMBL:X60316) AbaA ORFA (192 aa), fasta scores; opt: 248 z-score: 257.6 E(): 4.1e-07, 34.2% identity in 187 aa overlapC-terminus is similar to several RsbU homologs e.g. Bacillus licheniformis TR:O50229 (EMBL:AF034567) putative sigma B regulator similar to B. subtilis RsbU phosphatase (335 aa), fasta scores; opt: 232 z-score: 196.5 E(): 0.001, 26.3% identity in 240 aa overlap.
 
 
 0.817
SCO4654
DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 
 0.804
SCO4655
DNA-directed RNA polymerase beta' chain (fragment); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 
 0.784
SCO4677
SCD31.02c, possible regulatory protein, len: 144 aa; similar to TR:CAB60156 (EMBL:AL132824) Streptomyces coelicolor putative regulatory protein SCAH10.02, 160 aa; fasta scores: opt: 396 z-score: 500.7 E(): 1.9e-20; 51.7% identity in 143 aa overlap.
    
 
 0.778
SCO4036
Uncharacterized protein SCO4036; 2SCD60.02c, hypothetical protein, len: 97 aa; identical to previously sequenced SW:YRPX_STRCO (EMBL:L11648) Streptomyces coelicolor hypothetical 11.1 kDa protein in RpoX 5' region, 97 aa.
       0.747
SCO4037
2SCD60.03c, possible small membrane protein, len: 58 aa. Contains possible hydrophobic membrane spanning region.
       0.747
SCO4034
2SC10A7.38c, probable RNA polymerase sigma factor, len: 318 aa; highly similar to TR:Q9RIS5 (EMBL:AJ249581) Streptomyces coelicolor A3(2) Sig15 protein, 304 aa; fasta scores: opt: 1201 z-score: 1341.5 E(): 0; 66.6% identity in 287 aa overlap and to SW:RPOF_STRCO (EMBL:L11648) Streptomyces coelicolor RNA polymerase sigma-F factor SigF or RpoX, 287 aa; fasta scores: opt: 950 z-score: 1063.4 E(): 0; 58.6% identity in 261 aa overlap. Contains Pfam match to entry PF00140 sigma70, Sigma-70 factor and match to Prosite entry PS00715 Sigma-70 factors family signature 1. Also contains a possible [...]
 
   
0.744
SCO3549
Putative anti-sigma factor antagonist; Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B (By similarity).
 
 
 0.713
SCO1950
Hypothetical protein; Involved in cell division and chromosome segregation (By similarity). Involved in sporulation. May coordinate the cessation of aerial hyphae growth and subsequent chromosome segregation and/or septation. Required for expression of the ParB partioning protein during sporogenesis. Activates its own transcription and represses WhiB. Binds with low affinity to its own promoter and to the Parp2 sporulation-specific promoter. Also binds directly to the RNA polymerase sigma factor WhiG, leading to inhibition of WhiG-dependent transcription in a dose-dependent manner ; Be [...]
      
 0.711
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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