STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO4041Putative uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (214 aa)    
Predicted Functional Partners:
SCO4909
SCK13.01c, possible ATP-binding protein, len: 258 aa. Contains match to Prosite entry PS00017 ATP/GTP-binding site motif A (P-loop).
  
 0.997
SCO4890
2SCK8.16, deoA, thymidine phosphorylase, len: 427 aa; similar to SW:TYPH_ECOLI (EMBL:U14003) Escherichia coli thymidine phosphorylase (EC 2.4.2.4) DeoA, 440 aa; fasta scores: opt: 874 z-score: 920.7 E(): 0; 41.7% identity in 436 aa overlap. Contains Pfam match to entry PF00591 Glycos_transf_3, glycosyl transferase family and match to Prosite entry PS00647 Thymidine and pyrimidine-nucleoside phosphorylases signature.
 
 
 0.980
SCO1481
SC9C5.05c, pyrF, orotidine 5'-phosphate decarboxylase, len: 278 aa; similar to SW:DCOP_MYCTU (EMBL:Z80108) Mycobacterium tuberculosis orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) PyrF or UraA, 274 aa; fasta scores: opt: 800 z-score: 874.6 E(): 0; 51.1% identity in 282 aa overlap. Contains Pfam match to entry PF00215 OMPdecase, Orotidine 5'-phosphate decarboxylases and match to Prosite entry PS00156 Orotidine 5'-phosphate decarboxylase active site; Belongs to the OMP decarboxylase family. Type 2 subfamily.
  
 
 0.971
SCO5626
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
  
 
 0.970
SCO1488
Pyrimidine operon regulatory protein; Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.
     
 0.954
SCO4917
Putative purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
  
 
 0.937
SCO4634
SCD82.05c, possible hydrolase, len: 434 aa; similar to SW:ATZC_PSESD (EMBL:AF017572) Pseudomonas sp. N-isopropylammelide isopropyl amidohydrolase (EC 3.5.1.-) AtzC, 403 aa; fasta scores: opt: 292 z-score: 291.5 E(): 8.2e-09; 23.5% identity in 383 aa overlap.
  
 
 0.924
SCO4785
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
  
 0.924
SCO1971
Conserved hypothetical protein; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family.
    
  0.909
SCO4152
SCD84.19, possible secreted 5'-nucleotidase, len: 612 aa; similar to SW:5NTD_DISOM (EMBL:X62278) Discopyge ommata 5'-nucleotidase precursor (EC 3.1.3.5) (ecto-nucleotidase), 577 aa; fasta scores: opt: 322 z-score: 332.6 E(): 4.6e-11; 24.6% identity in 574 aa overlap. Contains Pfam match to entry PF01009 5_nucleotidase, 5'-nucleotidase and possible N-terminal region signal peptide sequence; Belongs to the 5'-nucleotidase family.
     
 0.904
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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