STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO4104SCD17.08c, possible integral membrane protein, len: 218 aa. Similar to several hypothetical membrane proteins e.g. Streptomyces coelicolor TR:O86576 (EMBL; AL031184) putative integral membrane protein SC2A11.15 (219 aa), fasta scores opt: 503 z-score: 576.2 E(): 9.7e-25 41.6% identity in 209 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. (218 aa)    
Predicted Functional Partners:
SCO4103
Peptidase; SCD17.07c. probable peptidase, len : 423 aa. Similar to many e.g. Sulfolobus solfataricus SW:CBPX_SULSO (EMBL; Z48497) thermostable carboxypeptidase (EC 3.4.17.-) (393 aa), fasta scores opt: 623 z-score: 708.6 E(): 4.1e-32 34.0% identity in 400 aa overlap. Contains a Pfam match to entry PF01546 Peptidase_M20.
       0.737
SCO4102
SCD17.06c, possible MerR family transcriptional regulator, len:319 aa. Similar to many other MerR family regulators e.g. Bradyrhizobium sp. (strain NC92) SW:NOLA_BRASN (EMBL; U33192) nodulation protein NolA (237 aa), fasta scores opt: 251 z-score: 286.3 E(): 1.4e-08 28.9% identity in 225 aa overlap. Contains a Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR family and a probable helix-turn-helix motif between residues 9..30 (+3.43 SD).
       0.544
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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