STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO4120SCD72A.06, conserved hypothetical protein, len: 552 aa; similar in regions to many from Streptomyces coelicolor eg. TR:Q9ZBJ0 (EMBL:AL035161) conserved hypothetical protein (860 aa) fasta scores; opt: 906, z-score: 1019.8, E(): 0, 43.5% identity in 370 aa overlap. (552 aa)    
Predicted Functional Partners:
SCO3549
Putative anti-sigma factor antagonist; Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B (By similarity).
 
   0.820
SCO7573
SC5F1.27c, probable anti-sigma factor antagonist, len: 114 aa; similar to SW:RSBV_STRCO (EMBL:AF134889) Streptomyces coelicolor anti-sigma factor B antagonist BldG, 113 aa; fasta scores: opt: 320 z-score: 436.5 E(): 8.8e-17; 49.5% identity in 99 aa overlap. Contains Pfam match to entry PF01740 STAS, STAS domain; Belongs to the anti-sigma-factor antagonist family.
 
   0.788
SCO4119
SCD72A.05, possible NADH dehydrogenase, len: 442aa; similar to many eg. TR:Q9ZC17 (EMBL:AL033505) putative dehydrogenase from Streptomyces coelicolor SC1E6.05 (629 aa) fasta scores; opt: 893, z-score: 1049.2, E(): 0, 38.5% identity in 452 aa overlap and SW:P00393 (DHNA_ECOLI) NADH dehydrogenase Ndh (EC 1.6.99.3) from Escherichia coli (433 aa) fasta scores; opt: 404, z-score: 477.0, E(): 4.2e-19, 27.0% identity in 389 aa overlap.
       0.749
SCO3067
SCE25.08c, putative anti anti sigma factor, len: 125 aa; identical to previously sequenced TR:CAB55835 (EMBL:AJ249581) Streptomyces coelicolor A3(2) putative anti anti sigma factor, 125 aa. Contains Pfam match to entry PF01740 SpoIIAA, SpoIIAA family; Belongs to the anti-sigma-factor antagonist family.
 
   0.715
SCO1327
2SCG61.09, possible integral membrane protein, len: 387 aa; similar to many predicted integral membrane protein especially others from Streptomyces coelicolor e.g. TR:CAB69689 (EMBL:AL137165) putative integral membrane protein (375 aa) fasta scores; opt: 481, z-score: 562.8, E(): 7.2e-24, 35.7% identity in 387 aa overlap. Contains possible membrane-spanning hydrophobic regions.
  
     0.714
SCO4613
SCD39.13, possible integral membrane protein, len: 88 aa; similar to SW:YEAQ_ECOLI (EMBL:AE000274) Escherichia coli hypothetical 8.7 kDa protein in GapA-Rnd intergenic region YeaQ, 82 aa; fasta scores: opt: 233 z-score: 300.6 E(): 2.8e-09; 42.5% identity in 80 aa overlap. Contains possible hydrophobic membrane spanning regions.
   
  
 0.662
SCO2255
SCC75A.01c, possible membrane protein, partial CDS, len: > 268 aa. Highly similar to another putative membrane protein from Streptomyces coelicolor TR:CAB45459(EMBL:AL079348) SC66T3.03 (330 aa), fasta scores opt: 695 z-score: 823.4 E():0 54.8% identity in 241 aa overlap. Contains possible membrane spanning hydrophobic domains; SC1G2.17c, unknown, partial CDS, len: > 116 aa. Highly similar to the C-terminus of Streptomyces coelicolor TR:Q9XAL0(EMBL:AL079348) putative membrane protein SC66T3.03 (330 aa), fasta scores opt: 472 z-score: 600.5 E(): 4.6e-26 66.1% identity in 109 aa overlap.
   
  
 0.650
SCO2807
2SCC13.15, possible integral membrane protein, len: 329 aa; similar to TR:CAB90881 (EMBL:AL355752) Streptomyces coelicolor putative integral membrane protein SC10B7.28, 287 aa; fasta scores: opt: 598 z-score: 630.9 E(): 1.2e-27; 37.7% identity in 284 aa overlap. Contains possible hydrophobic membrane spanning regions.
      
 0.646
SCO5742
SC9A10.06c, putative membrane protein, len: 79 aa. Contains possible hydrophobic membrane spanning region.
      
 0.646
SCO2419
SC8A2.07c, possible secreted protein, len: 418 aa; similar to TR:O53967 (EMBL:AL022073) Mycobacterium tuberculosis mce-family protein MTV051.04, 425 aa; fasta scores: opt: 548 z-score: 564.7 E(): 6.2e-24; 33.0% identity in 367 aa overlap. Contains Pfam match to entry PF02470 mce. Also contains possible N-terminal region signal peptide sequence.
      
 0.642
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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