STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO4155SCD84.22c, probable two-component system sensor, len: 481 aa; similar to TR:O53895 (EMBL:AL021999) Mycobacterium tuberculosis putative two-component sensor, MTV044.10, 504 aa; fasta scores: opt: 884 z-score: 949.8 E(): 0; 39.4% identity in 482 aa overlap and to SW:AFQ2_STRCO (EMBL:D10654) Streptomyces coelicolor sensor protein AfsQ2 (EC 2.7.3.-), 535 aa; fasta scores: opt: 404 z-score: 435.9 E(): 8e-17; 31.4% identity in 526 aa overlap. Contains Pfam matches to entries PF00672 DUF5, Domain found in bacterial signal proteins and PF00512 signal, Histidine kinase and correctly situated ma [...] (481 aa)    
Predicted Functional Partners:
SCO4156
SCD84.23c, probable two-component systen response regulator, len: 248 aa; similar to SW:COPR_PSESM (EMBL:L05176) Pseudomonas syringae transcriptional activator protein CopR, 227 aa; fasta scores: opt: 610 z-score: 735.3 E(): 0; 42.7% identity in 227 aa overlap and to TR:O53894 (EMBL:AL021999) Mycobacterium tuberculosis putative two-component response regulator MTV044.09, 230 aa; fasta scores: opt: 933 z-score: 1119.0 E(): 0; 62.9% identity in 229 aa overlap. Contains Pfam matches to entries PF00072 response_reg, Response regulator receiver domain and PF00486 trans_reg_C, Transcriptiona [...]
 
 0.999
SCO7076
SC3A4.02, putative two-component histidine kinase, len: 483 aa. Similar in parts to Agrobacterium tumefaciens SW:CHVG_AGRTU(EMBL:L18860) putative two-component histidine kinase required for virulence (690 aa), fasta scores, opt:399 z-score: 426.8 E(): 2.6e-16 33.1% identity in 357 aa overlap. Also similar to Streptomyces coelicolor SCD84.23c (481 aa), fasta scores opt: 874 z-score: 748.4 E():0 39.8% identity in 480 aa overlap. Contains a Pfam match to entry PF00672 DUF5, Domain found in bacterial signal proteins and a Pfam match to entry PF00512 signal, Histidine kinase. Contains proba [...]
  
  
 
0.916
SCO5283
SCCB12.07c, possible two-component system response regulator, len: 244 aa; similar to TR:Q9ZEP4 (EMBL:AJ131213) Streptomyces coelicolor response regulator CseB or SCE94.09, 234 aa; fasta scores: opt: 632 z-score: 771.1 E(): 0; 44.3% identity in 230 aa overlap and to SW:RESD_BACSU (EMBL:L09228), 240 aa; fasta scores: opt: 573 z-score: 699.9 E(): 1.6e-31; 39.7% identity in 234 aa overlap. Contains Pfam matches to entries PF00072 response_reg, Response regulator receiver domain and PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal.
 
 
 0.901
SCO2171
SC5F7.30, probable secreted protease, len: 362aa; similar to many egs. SW:HTRA_ECOLI Protease Do from Escherichia coli (474 aa) fasta scores; opt: 505, z-score: 503.1, E(): 1.1e-20, (39.1% identity in 294 aa overlap). Contains possible membrane spanning hydrophobic regions. Also contains Pfam matches to entry PF00089 trypsin, Trypsin and to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF).
    
 0.860
SCO3977
SCBAC25E3.14, possible protease (putative secreted protein), len: 519aa: similar to many eg. TR:Q9FBK9 (EMBL:AL390975) putative protease SCP8.12 from Streptomyces coelicolor (542 aa) fasta scores; opt: 1265, Z-score: 796.4, 43.636% identity (47.431% ungapped) in 550 aa overlap and TR:O06291 (EMBL:Z98260) HtrA from Mycobacterium tuberculosis (549 aa) fasta scores; opt: 614, Z-score: 396.6, 34.870% identity (37.826% ungapped) in 499 aa overlap. Contains Pfam match to entry PF00089 trypsin, Trypsin and Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF). Contains possi [...]
    
 0.860
SCO5149
SCP8.12, possible protease, len: 542 aa; C-terminal region similar to TR:O53896 (EMBL:AL021999) Mycobacterium tuberculosis putative serine protease MTV044.11, 464 aa; fasta scores: opt: 803 z-score: 614.5 E(): 9.2e-27; 39.4% identity in 469 aa overlap and to TR:AAF61294 (EMBL:AF155705) Lactococcus lactis serine protease HtrA, 408 aa; fasta scores: opt: 536 z-score: 415.8 E(): 1.1e-15; 34.8% identity in 310 aa overlap. Contains Pfam matches to entries PF00089 trypsin, Trypsin and PF00595 PDZ, PDZ domain (Also known as DHR or GLGF).
    
 0.860
SCO3717
Putative cation transport system component; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
  
  
 0.845
SCO3718
Putative cation transport system component; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane.
  
  
 0.838
SCO7075
SC3A4.01, two component response regulator protein, len: 230 aa. Highly similar to Pseudomonas syringae (pv. tomato) SW:COPR_PSESM (EMBL:L05176) transcriptional activator of copper resistance operon, CopR (227 aa) fasta scores, opt: 549 z-score: 653.7 E(): 5.9e-29 41.8% identity in 225 aa overlap and Synechococcus sp. (strain PCC 7942) (Anacystis nidulans R2)SW:SPHR_SYNP7(EMBL; D13172) response regulator of alkaline phosphatase, SphR (257 aa) fasta scores, opt: 554 z-score: 658.8 E(): 3.1e-29 40.8% identity in 233 aa overlap. Also similar to Streptomyces coelicolor SCD84.24c (248 aa), [...]
 
 
 0.830
SCO4907
Transcriptional regulatory protein; Forms part of a two-component regulatory system AfsQ1/AfsQ2 involved in secondary metabolism.
 
 
 0.801
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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