STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO4313SCD95A.46, possible regulatory protein, len: 216 aa; similar to TR:CAB56658 (EMBL:AL121596) Streptomyces coelicolor putative tetR family transcriptional regulator SCF51A.06, 177 aa; fasta scores: opt: 164 z-score: 202.9 E(): 0.00077; 32.0% identity in 103 aa overlap. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family and possible helix-turn-helix motif at residues 37..58 (+5.35 SD). (216 aa)    
Predicted Functional Partners:
SCO4314
SCD95A.47, hypothetical protein, len: 227 aa; similar to TR:O53480 (EMBL:AL021899) Mycobacterium tuberculosis hypothetical 23.2 kD protein MTV018.23, 213 aa; fasta scores: opt: 178 z-score: 217.9 E(): 0.00011; 29.0% identity in 200 aa overlap.
       0.766
SCO4312
SCD95A.45c, hypothetical protein, len: 262 aa; similar to TR:Q9I3L7 (EMBL:AE004578) Pseudomonas aeruginosa hypothetical protein PA1495, 208 aa; fasta scores: opt: 479 Z-score: 529.6 E(): 7.2e-22; 44.330% identity in 194 aa overlap. High content in alanine amino acid residues. Contains also a TTA leucine codon, possible target for bldA regulation.
       0.584
SCO4311
SCD95A.44c, hypothetical protein, len: 365 aa; similar to TR:O31648 (EMBL:Z99110) Bacillus subtilis YjdG protein, 168 aa; fasta scores: opt: 214 z-score: 251.8 E(): 1.5e-06; 30.5% identity in 154 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family.
       0.577
SCO0622
SCF56.06, probable tetR-family transcriptional regulator, len: 213 aa; similar to TR:CAB58268 (EMBL:AL121849) Streptomyces coelicolor putative tetR family transcriptional regulator SCF6.04, 180 aa; fasta scores: opt: 240 z-score: 284.5 E(): 1.8e-08; 34.5% identity in 177 aa overlap and to SW:TCMR_STRG (EMBL:M80674) Streptomyces glaucescens tetracenomycin C transcriptional repressor TcmR, 226 aa; fasta scores: opt: 212 z-score: 251.4 E(): 1.3e-06; 35.2% identity in 182 aa overlap. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family and a possible helix- [...]
  
   
 0.573
SCO0466
SCF76.06, probable araC family transcriptional regulator, len: 327 aa. Highly similar to many including the Streptomyces coelicolor hypothetical regulators: TR:CAB40696 (EMBL; AL049587) SC5F2A.29 (325 aa), fasta scores opt: 857 z-score: 962.2 E():0 45.8% identity in 323 aa overlap and TR:CAB46927 (EMBL; AL096822) SCGD3.05 (334 aa), fasta scores opt: 617 z-score: 694.7 E(): 2.4e-31 38.6% identity in 332 aa overlap. In addition to Streptomyces lividans SW:YCP1_STRLI (EMBL; U02635) hypothetical protein in CPOL 5'region (ORF1) (fragment) (141 aa), fasta scores opt: 908 z-score: 1024.0 E(): [...]
  
   
 0.565
SCO4639
SCD82.10, hypothetical protein, len: 201 aa; similar to TR:CAB52009 (EMBL:AL109663) Streptomyces coelicolor putative transcriptional regulator SC4A10.33, 209 aa; fasta scores: opt: 138 z-score: 174.2 E(): 0.028; 30.3% identity in 165 aa overlap.
  
   
 0.550
SCO4315
SCD95A.48, possible homeostasis protein, len: 229 aa; similar to SW:CUTC_ECOLI (EMBL:L38618) Escherichia coli copper homeostasis protein CutC, 248 aa; fasta scores: opt: 302 z-score: 336.1 E(): 2.9e-11; 31.3% identity in 208 aa overlap; Belongs to the CutC family.
       0.544
SCO0062
SCJ4.43c, probable LacI family transcriptional regulator, len: 367 aa; similar to many transcriptional regulators e.g. SW:GALR_ECOLI galactose operon repressor (343 aa) fasta scores; opt: 549, z-score: 636.2, E(): 4.5e-28, (32.5% identity in 332 aa overlap). Contains Pfam matches to entry PF00532 Peripla_BP_like, Periplasmic binding proteins and LacI family and entry PF00356 lacI, Bacterial regulatory proteins, lacI family. Contains possible helix-turn-helix motif (+3.86 SD) 26-47.
      
 0.483
SCO0266
SCF1.08c, possible transcriptional regulator, len: 325aa; similar to many eg. TR:CAB43482 (EMBL:Y18527) PobR regulator from Pseudomonas sp. strain HR199 (293 aa) fasta scores; opt: 254, z-score: 302.3, E(): 1.8e-09, (30.3% identity in 254 aa overlap). Also similar to TR:O88020 (EMBL:AL031107) putative transcriptional regulator from Streptomyces coelicolor (301 aa) fasta scores; opt: 318, z-score: 376.7, E(): 1.3e-13, (37.2% identity in 253 aa overlap). Contains Pfam match to entry PF00165 HTH_2, Bacterial regulatory helix-turn-helix proteins, araC family.
      
 0.483
SCO0940
SCM10.28, possible marR-family regulatory protein, len: 157 aa; weakly similar to TR:O07458 (EMBL:U75363) Rhodopseudomonas palustris putative regulatory protein, 175 aa; fasta scores: opt: 150 z-score: 189.7 E(): 0.0036; 28.1% identity in 160 aa overlap. Contains Pfam match to entry PF01047 MarR, MarR family.
      
 0.483
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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