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mqnB protein (Streptomyces coelicolor) - STRING interaction network
"mqnB" - Futalosine hydrolase in Streptomyces coelicolor
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Predicted Interactions
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mqnBFutalosine hydrolase; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). Does not accept aminodeoxyfutalosine (AFL) as a substrate; Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily (209 aa)    
Predicted Functional Partners:
mqnD
1,4-dihydroxy-6-naphtoate synthase; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) (282 aa)
 
     
  0.995
mqnC
Cyclic dehypoxanthine futalosine synthase; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) (399 aa)
 
   
  0.994
mqnA
Chorismate dehydratase; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnA subfamily (282 aa)
 
     
  0.969
mqnE
Aminodeoxyfutalosine synthase; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1- carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate (387 aa)
 
     
  0.954
ubiA
Putative octaprenyltransferase; UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin (301 aa)
 
     
  0.939
SCO5662
Aminodeoxyfutalosine deaminase; Catalyzes the deamination of aminodeoxyfutalosine (AFL) into futalosine (FL), a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family (387 aa)
   
 
  0.913
ubiX
Flavin prenyltransferase UbiX; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN (216 aa)
 
     
  0.904
SCO4490
SCD69.10, decarboxylase, len- 485 aa; similar to SW-Y209_ARCFU (EMBL-AE001091) Archaeoglobus fulgidus hypothetical protein AF0209, 481 aa; fasta scores- opt- 1557 z-score- 1800.8 E()- 0; 48.6% identity in 484 aa overlap and to SW-P26615 (UBID_ECOLI) 3-Octaprenyl-4-hydroxybenzoate carboxy-lyase from Escherichia coli (497 aa) fasta scores; opt- 1293, Z-score- 1478.5, 40.162% identity (41.336% ungapped) in 493 aa overlap. Contains Pfam match to entry PF01977 UPF0096, Protein of unknown function (485 aa)
   
     
  0.869
SCO5431
Putative secreted nucleosidase; SC6A11.07c, possible nucleosidase, len- 287 aa; similar to many e.g. SW-P24247 (PFS_ECOLI) MTA/SAH nucleosidase (P46) from Escherichia coli (232 aa) fasta scores- opt- 211, z-score- 251.7, E()- 1.3e-06, 27.1% identity in 210 aa overlap. Contains Pfam match to entry PF01048 PNP_UDP_1, Phosphorylase family (which includes some nucleosidases) and possible N-terminal signal sequence (287 aa)
           
  0.831
ubiE
Demethylmenaquinone methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) (231 aa)
         
  0.774
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor, Streptomyces coelicolor A3(2)
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