STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO4329SCD12A.12c, possible integral membrane protein, len: 463 aa; similar to TR:Q9X8T4 (EMBL:AL049826) Streptomyces coelicolor putative membrane protein SCH24.20c, 425 aa; fasta scores: opt: 305 z-score: 344.1 E(): 1.1e-11; 28.7% identity in 411 aa overlap. Contains possible hidrophobic membrane spanning regions. (463 aa)    
Predicted Functional Partners:
SCO6896
SC1B2.02, possible integral membrane protein, len: 411 aa. Weakly similar to several e.g. Escherichia coli TR:Q47390(EMBL:D16251) erythromycin resistance determinant, MrX (388 aa), fasta scores opt: 263 z-score: 283.2 E(): 2.6e-08 26.5% identity in 389 aa overlap. Contains multiple possible membrane spanning hydrophobic domains.
      
 0.799
SCO0397
SCF62.23, possible integral membrane protein, len:429 aa. Weakly similar to several proteins of undefined function e.g. Synechocystis sp. (strain PCC 6803) TR:P72591 (EMBL; D90899) iron(III) dicitrate transport system permease protein FecD (349 aa), fasta scores opt: 154 z-score: 170.4 E(): 0.039 25.4% identity in 334 aa overlap. Contains multiple possible membrane spanning hydrophobic domains.
      
 0.779
SCO4328
SCD12A.11c, possible lipoprotein, len: 154 aa. Contains correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site and possible N-terminal region signal peptide sequence.
       0.779
SCO4795
SCD63A.06c, possible integral membrane protein, len: 338 aa; similar to TR:O88074 (EMBL:AL031541) Streptomyces coelicolor putative integral membrane protein SCI35.39,394 aa; fasta scores: opt: 142 z-score: 173.6 E(): 0.033; 28.0% identity in 311 aa overlap. Contains possible hydrophobic membrane spanning regions.
      
 0.779
SCO5531
SC1C2.12c, probable integral membrane protein, len: 334 aa; similar to TR:Q98DR8 (EMBL:AP003004) Rhizobium loti (Mesorhizobium loti) putative integral membrane protein MLL4580, 308 aa; fasta scores: opt: 503 Z-score: 515.3 E(): 4.5e-21; 33.904% identity in 292 aa overlap. COntains possible hydrophobic membrane spanning regions.
      
 0.778
SCO0874
SCM1.07c, possible integral membrane protein, len: 230 aa. Highly similar to Streptomyces coelicolor TR:Q9X897(EMBL:AL049645) putative integral membrane protein SCE2.02c (234 aa), fasta scores opt: 1217 z-score: 1265.3 E():0 82.8% identity in 233 aa overlap. Also weakly similar to several other proteins of undefined function e.g. Mycobacterium tuberculosis TR:P96876(EMBL:Z92771) hypothetical 23.6 KD protein (222 aa), fasta scores opt: 360 z-score: 447.3 E(): 1.4e-17 33.8% identity in 195 aa overlap. Contains multiple possible membrane spanning hydrophobic domains.
      
 0.771
SCO4326
Conserved hypothetical protein; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
       0.715
SCO4327
Conserved hypothetical protein SCD12A.10c; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). Does not accept aminodeoxyfutalosine (AFL) as a substrate; Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily.
       0.715
SCO4330
SCD12A.13, hypothetical protein, len: 308 aa; similar to TR:O33058 (EMBL:Z99494) Mycobacterium leprae hypothetical 28.2 kD protein MLCB57.28, 269 aa; fasta scores: opt: 432 z-score: 470.7 E(): 9.4e-19; 43.3% identity in 270 aa overlap.
       0.709
SCO4331
SCD12A.14, hypothetical protein, len: 1042 aa; similar to TR:CAB61192 (EMBL:AL132973) Streptomyces coelicolor hypothetical 93.0 kD protein SCF91.35, 884 aa; fasta scores: opt: 160 z-score: 164.2 E(): 0.11; 26.0% identity in 666 aa overlap.
 
     0.699
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: medium (56%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.