STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO4375SCD10.07, possible marR-family regulatory protein, len: 164 aa; similar to TR:CAB87337 (EMBL:AL163672) Streptomyces coelicolor putative regulatory protein SCE50.15, 168 aa; fasta scores: opt: 226 z-score: 281.6 E(): 3.3e-08; 39.3% identity in 135 aa overlap. Contains Pfam match to entry PF01047 MarR, MarR family. (164 aa)    
Predicted Functional Partners:
SCO4376
Hypothetical protein SCD10.08; SCD10.08, unknown, len: 169 aa. Contains 3x degenerate repeat: T(T/A)P and a 2x conserved repeat TTDAA.
       0.875
SCO0882
Hypothetical protein SCM1.15; SCM1.15, unknown, len: 115 aa. Highly similar to another protein of undefined function from Streptomyces coelicolor TR:CAB52051(EMBL:AL109732) hypothetical 14.0 KD protein SC7H2.09c (126 aa), fasta scores opt: 234 z-score: 312.6 E(): 4.6e-10 41.8% identity in 91 aa overlap.
       0.560
SCO4377
SCD10.09, probable serine-threonine protein kinase, len: 580 aa; similar to SW:AFSK_STRCO (EMBL:D15062) Streptomyces coelicolor serine-threonine protein kinase AfsK (EC 2.7.1.-), 799 aa; fasta scores: opt: 953 z-score: 715.3 E(): 2.3e-32; 43.2% identity in 438 aa overlap. Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain and matches to Prosite entries PS00107 Protein kinases ATP-binding region signature and PS00108 Serine/Threonine protein kinases active-site signature. Contains possible hydrophobic membrane spanning region.
   
   0.555
SCO4374
SCD10.06, possible integral membrane protein, len: 295 aa; similar to TR:Q9RUT6 (EMBL:AE001976) Deinococcus radiodurans PecM-related protein DR1295, 302 aa; fasta scores: opt: 769 z-score: 839.6 E(): 0; 47.1% identity in 291 aa overlap. Contains Pfam match to entry PF00892 DUF6, Integral membrane protein. Contains also possible hydrophobic membrane spanning regions.
       0.524
SCO3585
Hypothetical protein; SCH66.06, unknown, len: 113aa.
 
     0.438
SCO4460
SCD65.03, hypothetical protein, len: 156 aa; similar to the C-terminal region of the SCP1 plasmid borne TR:Q9AD28 (EMBL:AL590463) Streptomyces coelicolor hypothetical protein SCP1.122, 246 aa; fasta scores: opt: 444 Z-score: 518.8 E(): 2.9e-21; 55.906% identity in 127 aa overlap. Contains match to Prosite entry PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature.
  
    0.404
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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