STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO4446SCD6.24, possible integral membrane protein, len: 405 aa; similar to TR:CAB72211 (EMBL:AL138851) Streptomyces coelicolor putative transport protein SCE59.24, 366 aa; fasta scores: opt: 204 z-score: 229.5 E(): 2.5e-05; 27.1% identity in 358 aa overlap. Contains possible hydrophobic membrane spanning regions. (405 aa)    
Predicted Functional Partners:
SCO4445
SCD6.23c, possible transcriptional regulator, len: 327 aa; similar to TR:Q9XBC8 (EMBL:AL078635) Streptomyces coelicolor putative transcriptional regulator CZA382.23c, 335 aa; fasta scores: opt: 347 z-score: 400.5 E(): 7.5e-15; 36.7% identity in 270 aa overlap.
 
     0.949
SCO4444
SCD6.22c, probable glutathione peroxidase, len: 193 aa; similar to SW:GPO_LACLC (EMBL:AJ000109) Lactococcus lactis glutathione peroxidase (EC 1.11.1.9) Gpo, 157 aa; fasta scores: opt: 530 z-score: 660.6 E(): 2.4e-29; 54.9% identity in 142 aa overlap. Contains Pfam match to entry PF00255 GSHPx, Glutathione peroxidases and match to Prosite entry PS00460 Glutathione peroxidases selenocysteine active site.
       0.706
SCO4443
SCD6.21c, possible merR-family transcriptional regulator, len: 294 aa; similar to TR:AAF11989 (EMBL:AE002074) Deinococcus radiodurans transcriptional regulator, merR-family DR2448, 280 aa; fasta scores: opt: 465 z-score: 562.4 E(): 7.3e-24; 43.0% identity in 286 aa overlap. Contains Pfam match to entry PF00376 merR, Bacterial regulatory proteins, merR family and match to Prosite entry PS00552 Bacterial regulatory proteins, merR family signature.
       0.673
SCO5413
SC8F4.17, possible transcriptional regulator, len: 169 aa; similar to many proposed transcriptional regulators e.g. TR:CAB62730 (EMBL:AL133423) putative MarR-family transcriptional regulator from Streptomyces coelicolor (151 aa) fasta scores; opt: 184, z-score: 242.7, E(): 4.1e-06, 35.1% identity in 111 aa overlap. Contains Pfam match to entry PF01047 MarR, MarR family.
       0.560
SCO5414
SC8F4.18, putative membrane protein, len: 109 aa; previously sequenced therefore identical to TR:Q9X948 (EMBL:AJ237976). Also similar to SW:Z75555 (Y076_MYCTU) hypothetical protein from Mycobacterium tuberculosis (120 aa) fasta scores; opt: 248, z-score: 330.5, E(): 5.3e-11, 37.5% identity in 96 aa overlap. Contains possible hydrophobic membrane spanning regions.
       0.560
SCO6153
SC1A9.17c, possible regulatory protein, len: 424 aa; similar to TR:Q56084 (EMBL:D63904) ESA36 protein of undefined function from Streptomyces thermoviolaceus (334 aa) fasta scores; opt: 313, z-score: 401.9, E(): 4.1e-15, (30.0% identity in 337 aa overlap). Also similar to SW:BRPA_STRHY bialaphos biosynthetic pathway regulatory protein from Streptomyces hygroscopicus (256 aa), fasta scores; opt: 234, z-score: 233.8, E(): 9.5e-06, (30.1% identity in 163 aa overlap). Contains helix-turn-helix motif from: 1 to: 424, Score 1064 (+2.81 SD). Possible coiled-coil from 171 to 200 (30 residues) [...]
  
     0.539
SCO4221
Hypothetical protein; 2SCD46.35c, unknown, len: aa.
  
     0.522
SCO4524
SCD35.31, putative membrane protein, len: 239 aa. Contains possible hydrophobic membrane spanning region.
  
     0.517
SCO0657
SCF91.17, gvpS2, possible gas vesicle synthesis protein, len: 69 aa. Highly similar to Bacillus megaterium TR:O6869(EMBL:AF053765) gas vesicle protein GvpS (95 aa), fasta scores opt: 143 z-score: 203.5 E(): 0.00059 39.3% identity in 56 aa overlap and Streptomyces coelicolor TR:Q9ZC06 (EMBL:AL033505) putative gas vesicle synthesis protein GvpS (60 aa), fasta scores opt: 214 z-score: 298.0 E(): 3.2e-09 63.5% identity in 52 aa overlap. Contains a possible membrane spanning hydrophobic domain and a Pfam match to entry PF00741 Gas_vesicle, Gas vesicle protein.
  
     0.504
SCO0433
SCF51A.11, possible transcriptional regulator, len: 334 aa. Similar to Streptomyces coelicolor TR:Q9ZBT5 (EMBL; AL034446) putative regulatory protein SC1A9.17C (327 aa), fasta scores opt: 494 z-score: 573.8 E(): 1.3e-24 36.9% identity in 333 aa overlap. Contains a possible helix-turn-helix motif between residues 290..311 (+2.71 SD).
  
     0.474
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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