STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO4481SCD69.01, probable serine/threonine protein kinase (fragment), len: >607 aa; similar to SW:AFSK_STRCO (EMBL:D15062) Streptomyces coelicolor serine/threonine protein kinase AfsK, 799 aa; fasta scores: opt: 649 z-score: 427.0 E(): 2.5e-16; 35.8% identity in 408 aa overlap also similar to S. coelicolor SCD69.08 and TR:Q9ZN80 (EMBL:AB021679) Streptomyces coelicolor serine/threonine protein kinase PkaG, 592 aa; fasta scores: opt: 715 z-score: 417.5 E(): 1e-17; 32.7% identity in 538 aa overlap. Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain and matches to Pros [...] (632 aa)    
Predicted Functional Partners:
SCO7530
Putative regulatory protein; SC8G12.06c, possible regulatory protein, len: 360 aa. The N-terminus of this protein is similar to many regulatory proteins e.g. Deinococcus radiodurans TR:AAF11989(EMBL:AE002074) transcriptional regulator, MerR family (280 aa), fasta scores opt: 324 z-score: 367.6 E(): 5.1e-13 37.3% identity in 244 aa overlap. The C-terminus of this protein is similar to many hypothetical proteins and putative phosphatases e.g. Mycobacterium leprae TR:Q50188(EMBL:Z70722) putative phosphoprotein phosphatase (509 aa), fasta scores opt: 709 z-score: 790.9 E(): 0 54.6% identit [...]
 
 
 0.831
SCO3845
SCH69.15, possible protein phosphatase, len: 515aa; similar to many of undefined function egs. TR:P71588 (EMBL:Z80233) hypothetical protein from Mycobacterium tuberculosis (514 aa) fasta scores; opt: 989, z-score: 916.0, E(): 0, (42.9% identity in 536 aa overlap) and TR:Q50188 (EMBL:Z70722) putative phophoprotein phosphatase from Mycobacterium leprae (509 aa) fasta scores; opt: 966, z-score: 895.0, E(): 0, (40.0% identity in 530 aa overlap). Contains 2 Pfam matches to entry PF00481 PP2C, Protein phosphatase 2C. could have a role in signalling.
 
 
 0.820
SCO2450
SCC24.21, possible serine/threonine protein kinase (regulator), len: 1349 aa; N-terminal region similar to SW:PKAB_STRCO (EMBL:D86821) Streptomyces coelicolor serine/threonine protein kinase PkaB, 417 aa; blastp socres: Score = 109 (38.4 bits), Expect = 0.00070, Sum P(2) = 0.00070 Identities = 39/121 (32%), Positives = 60/121 (49%) and C-teminal region similar to SW:AFSR_STRCO (EMBL:D90155) Streptomyces coelicolor regulatory protein AfsR, 993 aa; fasta scores: opt: 510 z-score: 438.0 E(): 5.8e-17; 33.3% identity in 442 aa overlap. Contains Pfam match to entry PF00069 pkinase, Eukaryoti [...]
  
 
   0.783
SCO4817
SC2A6.02c, possible serine/threonine protein kinase, len: 452 aa; similar to TR:CAB82017 (EMBL:AL161755) Streptomyces coelicolor serine/threonine protein kinase SCD63.10, 380 aa; fasta scores: opt: 297 z-score: 312.5 E(): 6.3e-10; 28.8% identity in 379 aa overlap and to Streptomyces coelicolor SC2A6.05c, 712 aa; fasta scores: opt: 1410 z-score: 1253.9 E(): 0; 68.7% identity in 339 aa overlap. Contains Pfam matches to entries PF00069 pkinase, Eukaryotic protein kinase domain and PF01471 PG_binding_1, Putative peptidoglycan binding domain. Contains also possible hydrophobic membrane span [...]
  
     0.773
SCO4820
SC2A6.05c, possible serine/threonine protein kinase, len: 712 aa; C-terminal region similar to TR:O53510 (EMBL:AL021957) Mycobacterium tuberculosis serine/threonine protein kinase MTV021.09, 399 aa; fasta scores: opt: 289 z-score: 239.4 E(): 7.5e-06; 30.6% identity in 340 aa overlap and to Streptomyces coelicolor SC2A6.02c, 452 aa; fasta scores: opt: 1410 z-score: 964.7 E(): 0; 68.7% identity in 339 aa overlap. Contains 2 Pfam matches to entry PF00069 pkinase, Eukaryotic protein kinase domain. Contains also possible hydrophobic membrane spanning regions, 3x degenerate repeat: (T/H)GTGT [...]
 
     0.771
SCO2667
Hypothetical protein SC6D10.10; SC6D10.10, unknown, len: 482 aa.
 
 
 0.655
SCO3893
SCH24.15c, hypothetical protein, len: 563 aa; unknown function, previously partially sequenced as TR:O86855 (EMBL:AJ007313) Streptomyces coelicolor hypothetical protein (281 aa). Weakly similar to TR:Q53839 (EMBL:U19250) Streptomyces coelicolor protein kinase-like protein (565 aa), fasta scores; opt: 205 z-score: 204.5 E(): 0.00045, 25.1% identity in 263 aa overlap and to C-terminal half of TR:O05435 (EMBL:Z94121) Mycobacterium tuberculosis hypothetical protein (1184 aa) (26.9% identity in 557 aa overlap).
  
     0.620
SCO4480
SCD65.23c, possible tetR-family transcriptional regulatory protein, len: 205 aa; similar to TR:O53661 (EMBL:AL021929) Mycobacterium tuberculosis putative regulatory protein MTV034.04, 204 aa; fasta scores: opt: 193 z-score: 241.7 E(): 5.4e-06; 25.7% identity in 187 aa overlap. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family and possible helix-turn-helix motif at residues 37..58 (+2.77 SD).
       0.602
SCO1468
SCL6.25c, possible serine/threonine protein kinase, len: 774 aa; similar to TR:Q9ZBL8 (EMBL:AL035159) Mycobacterium leprae putative serine/threonine kinase MLCB1450.19c, 763 aa; fasta scores: opt: 682 z-score: 645.1 E(): 1.6e-28; 36.0% identity in 736 aa overlap and to SW:KMOS_MSVMO (EMBL:V01180) Moloney murine sarcoma virus MOS serine/threonine-protein kinase transforming protein (EC 2.7.1.-) V-MOS, 374 aa; fasta scores: opt: 230 z-score: 224.5 E(): 4.4e-05; 23.4% identity in 269 aa overlap. Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain.
  
     0.597
SCO1384
SC1A8A.04c, hypothetical protein, len: 267aa; similar to but longer than SW:Q50606 (Y0DG_MYCTU) hypothetical protein from Mycobacterium tuberculosis (162 aa) fasta scores; opt: 503, z-score: 488.2, E(): 9.2e-20, 56.0% identity in 141 aa overlap. Contains Pfam match to entry PF00498 FHA, FHA domain.
 
 
   0.491
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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