STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO4628Putative regulator; The imp locus inhibits the extrachromosomal maintenance of the Streptomyces plasmid SLP1. (269 aa)    
Predicted Functional Partners:
SCO4629
Conserved hypothetical protein; The imp locus inhibits the extrachromosomal maintenance of the streptomyces plasmid SLP1. May function as a transcriptional activator.
 
   
 0.983
SCO4620
SCD39.20c, traB1, possible sporulation-related protein, len: 681 aa; highly similar to TR:Q54679 (EMBL:U23762) Streptomyces phaeochromogenes essential for intermycelial plasmid transfer and pock formation, TraB, 678 aa; fasta scores: opt: 1845 z-score: 2002.9 E(): 0; 51.0% identity in 679 aa overlap and middle domain similar to middle domain of SW:SP3E_BACSU (EMBL:M17445) Bacillus subtilis stage III sporulation protein E, SpoIIIE, 787 aa; fasta scores: opt: 208 z-score: 224.4 E(): 4.9e-05; 26.7% identity in 344 aa overlap. Contains Pfam match to entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE [...]
     
 0.880
SCO4621
SCD39.21c, traA1, possible sporulation-related protein, len: 179 aa; highly similar to TR:Q54678 (EMBL:U23762) Streptomyces phaeochromogenes involved in intermycelial plasmid transfer TraA, 184 aa; fasta scores: opt: 472 z-score: 523.1 E(): 1.1e-21; 50.0% identity in 172 aa overlap.
      
 0.880
SCO4616
Excisionase; SCD39.16c, xis, excisionase, len: 61 aa; identical to previously sequenced TR:Q53965 (EMBL:X71358) Streptomyces coelicolor Xis, plasmid SLP1 DNA for xis and int genes, 61 aa.
     
 0.793
SCO3932
SCQ11.15c, probable gntR-family transcriptional regulator, len: 295 aa; similar to many e.g. TR:Q07191 (EMBL:Z19589), KorSA, Streptomyces ambofaciens plasmid pSAM2 transcriptional repressor (259 aa), fasta scores; opt: 292 z-score: 359.5 E(): 1.1e-12, 30.4% identity in 253 aa overlap. Also similar to CDS from other putative integrated plasmids in S.coelicolor e.g. SCE39.09c (EMBL:AL049573), korSA, regulatory protein (259 aa) (30.8% identity in 253 aa overlap). Part of a putative integrated plasmid similar to pSAM2. Contains probable helix-turn-helix motif at aa 35-56 (Score 1296, +3.60 [...]
  
     0.631
SCO1716
SCI11.05, possible gntR-family transcriptional regulator, len: 249 aa; weakly similar to many trancriptional regulators e.g. SW:FARR_ECOLI (EMBL:X15790), FarR, Escherichia coli fatty acyl responsive regulator (240 aa), fasta scores; opt: 213 z-score: 265.9 E(): 1.8e-07, 25.0% identity in 232 aa overlap. Similar to others from S.coelicolor e.g. SCE39.14c (EMBL:AL049573) S.coelicolor possible gntR-family regulator (243 aa) (29.5% identity in 224 aa overlap). Contains probable helix-turn-helix motif at aa 42-63 (Score 1296, +3.60 SD). Contains Pfam match to entry PF00392 gntR, Bacterial r [...]
  
     0.543
SCP1.91c
SCP1.91c, possible GntR-family transcriptional regulator, len: 252aa; similar to many from extrachromosomal genetic elements eg. TR:Q9RIQ2 (EMBL:AJ243257) KorA protein from plasmid pSNA1 of Streptomyces natalensis (245 aa) fasta scores; opt: 477, z-score: 554.9, E(): 1.9e-23, 37.9% identity in 243 aa overlap and SW:P22405 (KORA_STRLI) KorA protein from plasmid pIJ101 of Streptomyces lividans (241 aa) fasta scores; opt: 393, z-score: 459.0, E(): 4.3e-18, 34.9% identity in 235 aa overlap. Contains Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family and helix-turn [...]
 
     0.514
SCO5231
Putative gntR-family transcriptional regulator; Global regulator that is part of the nutrient-sensing system. In the absence of glucosamine 6-P (GlcN6P), represses the phosphotransferase system (PTS) specific for the uptake of N- acetylglucosamine (PTSNag), and genes involved in the metabolism of chitin, as well as several genes involved in development, thereby linking carbon availability to morphogenesis. Also regulates the expression of the ABC transporters DasABC and NgcEFG, which are involved in N,N'-diacetylchitobiose ((GlcNAc)2) uptake. Binds to the DNA consensus sequence 5'-ACTG [...]
  
     0.497
SCO7668
SC4C2.03, conserved hypothetical protein, len: 159 aa; similar to TR:O06195 (EMBL:Z95387) Mycobacterium tuberculosis hypothetical 24.2 kDa protein MTCYA10.15c, 225 aa; fasta scores: opt: 235 z-score: 263.9 E(): 3.6e-07; 43.7% identity in 103 aa overlap.
   
  
 0.449
SCO7351
SC9H11.05, possible AraC-family transcriptional regulator, len: 289 aa. Similar to several including: Streptomyces coelicolor TR:O69819(EMBL:AL023496) transcriptional regulator, SC1A6.14 (256 aa), fasta scores opt: 397 z-score: 464.2 E(): 2.2e-18 33.5% identity in 254 aa overlap and Escherichia coli SW:YEAM_ECOLI(EMBL:AE000274) hypothetical transcriptional regulator (273 aa), fasta scores opt: 438 z-score: 510.8 E(): 5.4e-21 33.2% identity in 232 aa overlap. Contains a Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family with the putative he [...]
   
    0.446
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (26%) [HD]