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adk protein (Streptomyces coelicolor) - STRING interaction network
"adk" - Adenylate kinase in Streptomyces coelicolor
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family (217 aa)    
Predicted Functional Partners:
secY
Protein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (437 aa)
 
   
  0.990
rplO
50S ribosomal protein L15; Binds to the 23S rRNA (151 aa)
   
   
  0.963
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (137 aa)
 
  0.955
pnp
Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3’- to 5’-direction (739 aa)
     
 
  0.949
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (165 aa)
   
 
  0.948
SCO5423
SC8F4.27c, pyk2, pyruvate kinase, len- 476 aa; strongly similar to many e.g. SW-Q46078 (KPYK_CORGL) pyruvate kinase from Corynebacterium glutamicum (Brevibacterium flavum) (475 aa) fasta scores; opt- 1693, z-score- 1907.7, E()- 0, 55.3% identity in 474 aa overlap and TRNEW-CAB52070 (EMBL-AL109732) pyruvate kinase from Streptomyces coelicolor (478 aa) fasta scores; opt- 2185, z-score- 2461.2, E()- 0, 69.3% identity in 473 aa overlap. Contains Pfam match to entry PF00224 PK, Pyruvate kinase and Prosite match to PS00110 Pyruvate kinase active site signature (476 aa)
 
 
  0.944
SCO2014
SC7H2.28c, pyk1, pyruvate kinase, len- 478 aa; strongly similar to many e.g. SW-KPYK_CORGL pyruvate kinase from Corynebacterium glutamicum (475 aa) fasta scores; opt- 1800, z-score- 2008.1, E()- 0, (59.6% identity in 473 aa overlap). Contains Pfam match to entry PF00224 PK, Pyruvate kinase and Prosite match to PS00110 Pyruvate kinase active site signature (478 aa)
 
 
  0.942
SCO1254
Adenylosuccinate lyase; Catalyzes two discrete reactions in the de novo synthesis of purines- the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily (480 aa)
   
  0.936
SCO5226
Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (791 aa)
   
 
  0.935
thiL
Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family (322 aa)
   
 
  0.933
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor, Streptomyces coelicolor A3(2)
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