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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO4744Putative holo-[acyl-carrier protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (123 aa)    
Predicted Functional Partners:
SCO2389
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family.
  
 
 0.945
SCO1996
dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
    
 0.913
SCO6673
SC5A7.23, unknown, len: 226 aa; similar to hypothetical proteins from Streptomyces and M. tuberculosis e.g. S. coelicolor TR:O24813 (EMBL:AB007189) (208 aa), fasta scores; opt: 674 z-score: 960.0 E(): 0, 49.1% identity in 214 aa overlap; Belongs to the P-Pant transferase superfamily.
      
 0.898
SCO5883
Hypothetical protein SC3F7.03c; SC3F7.03c, redU, unknown, len: 261 aa; Belongs to the P-Pant transferase superfamily.
      
 0.861
SCO4745
Putative alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.
  
  
 0.856
SCO0549
Putative acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family.
  
 
 0.828
SCO6827
SC4A9.04c, polyketide synthase, len: 2358 aa. Highly similar to many including: Stigmatella aurantiaca TR:AAF19813(EMBL:AF188287) polyketide synthase, MtAE, found within the Myxothiazol biosynthetic gene cluster (1947 aa), fasta scores opt: 2671 z-score: 2436.5 E():0 35.8% identity in 1770 aa overlap and Mycobacterium tuberculosis SW:PPSA_MYCTU(EMBL:Z74697) phenolpthiocerol synthesis polyketide synthase gene, PpsA (1876 aa), fasta scores opt: 2221 z-score: 2025.5 E(): 0 33.6% identity in 1761 aa overlap. Contains Prosite hits to PS00606 Beta-ketoacyl synthases active site and 2xPS00012 [...]
  
 
 0.777
SCO0492
SCF34.11c, probable peptide synthetase, len: 3643 aa; similar to parts of many antibiotic peptide synthetases e.g. the C-terminal half of TR:Q9Z4X6 (EMBL:AL035640) Streptomyces coelicolor CDA peptide synthetase I (7463 aa), fasta scores; opt: 1948 z-score: 1929.3 E(): 0, 33.7% identity in 3723 aa overlap. Also similar to parts of putative peptide synthetases from the exochelin biosynthesis locus of Mycobacterium smegmatis TR:O87314 (EMBL:AF027770), FxbC, putative peptide synthetase (4976 aa) (42.3% identity in 3756 aa overlap). Contains 3 Pfam matches to entry PF00550 pp-binding, Phosp [...]
  
 
 0.775
SCO3230
SCE63.03c, cdaPSI, CDA peptide synthetase I, len: 7463 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a putative multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the incorperation of the first 6 amino acids into the antibiotic structure. This ORF overlaps the downstream (cdaPSII) ORF by one base indicating possible translational coupling. Contains eight separate Pfam matches to entry PF00668 [...]
  
 
 0.775
SCO5890
SC3F7.10, redN, putative 8-amino-7-oxononanoate synthase, len: 640 aa; similar to many diverse transferases eg. BIOF_BACSH P22806 8-amino-7-oxononanoate synthase (389 aa), fasta scores; opt: 926 z-score: 888.4 E(): 0, 42.1% identity in 361 aa overlap. Also simlar to SC3F7.12 from aa 1700 to end (E(): 3.6e-15, 31.9% identity in 630 aa overlap). Contains Pfam match to entry aminotran_2 PF00222, Aminotransferases class-II, score 292.92 in C-terminus.
  
 
 0.769
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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