STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
SCO4752Putative O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (374 aa)    
Predicted Functional Partners:
SCO4750
Conserved hypothetical protein; SC6G4.28, unknown, len: 217 aa; similar to hypothetical proteins from many organisms e.g. YEAZ_ECOLI (231 aa), fasta scores; opt: 257 z-score: 332.3 E(): 3e-11, 33.9% ide ntity in 221 aa overlapand Y098_MYCTU MTCY78.08 (211 aa), f asta scores; opt: 453 z-score: 467.2 E(): 9.3e-19, 48.1% i dentity in 212 aa overlap. Also some similarity to downstre am protein gcp (SC6G4.30; E(): 0.00023, 26.5% identity in 2 34 aa overlap).
 
 
 0.998
SCO4747
Putative ATP/GTP binding protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD (By similarity).
 
 
 0.997
SCO7300
Hypothetical protein SC5F8.10c; SC5F8.10c, unknown, len: 410 aa.
  
 0.983
SCO4751
SC6G4.29, probable acetyltransferase, len: 177 aa; s imilar to e.g. RIMI_ECOLI ribosomal-protein-alanine acetyl transferase (148 aa), fasta scores; opt: 166 z-score: 257.4 E(): 4.5e-07, 33.3% identity in 120 aa overlap. Contains Pf am match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family, score 59.60, E-value 6.7e-14.
 
  
 0.968
SCO4753
Hypothetical protein; SC6G4.31, unknown, len: 90 aa.
       0.875
SCO1232
Urease accessory protein; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
     
 0.857
SCO3149
Putative dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
 
  
 0.834
SCO3884
SCH24.06, conserved hypothetical protein, len: 170 aa; previously sequenced as TR:O54595 (EMBL:Y16311) Streptomyces coelicolor jag-like protein (170 aa). Similar to SW:JAG_BACSU (EMBL:Z14225), jag, Bacillus subtilis SpoIIIJ associated protein (208 aa), fasta scores; opt: 231 z-score: 268.4 E(): 1.1e-07, 31.7% identity in 139 aa overlap, and other jag homologs e.g. TR:O53598 (EMBL:AL021426) Mycobacterium tuberculosis hypothetical protein (187 aa) (62.7% identity in 169 aa overlap).
  
   
 0.819
SCO2510
Conserved hypothetical protein SCC121.13c; Involved in DNA repair and RecF pathway recombination.
 
   
 0.805
SCO5791
Putative tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family.
 
   
 0.799
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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