STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO4764SC6G4.42c, probable dehydrogenase, len: 257 aa; simi lar to many members of the short-chain dehydrogenases/reduc tases family e.g. TR:Q54190 (EMBL:D14040) S. galilaeus keto acyl reductase aknIII (261 aa), fasta scores; opt: 350 z-sc ore: 438.4 E(): 3.5e-17, 33.5% identity in 233 aa overlap. Contains Pfam match to entry PF00106 adh_short, Alcohol/oth er dehydrogenases, short chain type, score 158.00, E-value 1.6e-43; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (257 aa)    
Predicted Functional Partners:
SCO4765
Conserved hypothetical protein; SC6G4.43c, unknown, len: 233 aa; similar to hypothet ical proteins e.g. M. tuberculosis TR:P95151 (EMBL:Z83859) MTCY359.09 (251 aa), fasta scores; opt: 716 z-score: 609.7 E(): 1e-26, 54.4% identity in 215 aa overlap.
  
    0.815
SCO4766
SC6G4.44, probable transcriptional regulator, len: 306 aa; similar to many members of the lysR family e.g. CYNR_ ECOLI cyn operon transcriptional activator (299 aa), fasta scores; opt: 371 z-score: 524.3 E(): 5.8e-22, 30.3% identity in 307 aa overlap. Contains PS00044 Bacterial regulatory proteins, lysR family signature, helix-turn-helix motif at aa 18-39 (Score 1603, +4.65 SD) and Pfam match to entry PF0 0126 HTH_1, Bacterial regulatory helix-loop-helix proteins, lysR family, score 161.30, E-value 1.6e-44.
       0.746
SCO4169
SCD66.06, probable oxidoreductase, len: 254 aa; similar to SW:2BHD_STREX Streptomyces exfoliatus 20-beta-hydroxysteroid dehydrogenase (EC 1.1.1.53), 255 aa; fasta scores: opt: 1285 z-score: 1410.5 E(): 0; 77.6% identity in 255 aa overlap. Contains Pfam matches to entries PF00106 adh_short, short chain dehydrogenase and PF00678 adh_short_C2, Short chain dehydrogenase/reductase C-terminus and match to Prosite entry PS00061 Short-chain dehydrogenases/reductases family signature.
  
 
   0.639
SCO0111
SCJ11.40, probable oxidoreductase, len: 753 aa; similar to many egs. TR:O32457 (EMBL:D87924) ORF7 from the putative polyketide synthase cluster of Actinomadura hibisca (246 aa) fasta scores; opt: 480, z-score: 498.5, E(): 2.1e-20, (38.3% identity in 248 aa overlap) and TR:Q54810 (EMBL:L35560) reductase from the doxorubicin polyketide synthase cluster of Streptomyces peucetius (251 aa) fasta scores; opt: 408, z-score: 425.7, E(): 2.4e-16, (33.7% identity in 243 aa overlap). Contains Pfam matches to entry PF00106 adh_short, short chain dehydrogenase and to entry PF00678 adh_short_C2, Sho [...]
  
 
   0.614
SCO2476
SC7A8.15c, probable dehydrogenase/reductase (putative secreted protein), len: 247 aa; similar to TR:CAB52925 (EMBL:AL109949) Streptomyces coelicolor putative oxidoreductase SCJ11.40, 250 aa; fasta scores: opt: 591 z-score: 665.9 E(): 1.1e-29; 43.1% identity in 246 aa overlap and to SW:2BHD_STREX AC:P19992 Streptomyces exfoliatus (Streptomyces hydrogenans) 20-beta-hydroxysteroid dehydrogenase (EC 1.1.1.53), 25 aa; fasta scores: opt: 414 z-score: 469.7 E(): 9e-19; 36.1% identity in 249 aa overlap. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase and PF00678 adh_s [...]
  
 
   0.596
SCO7389
Putative oxidoreductase; SC10G8.16, possible oxidoreductase, len: 292 aa. Similar to many including: Streptomyces clavuligerus TR:O54197(EMBL:AJ000671) clavulanate-9-aldehyde reductase (247 aa), fasta scores opt: 352 z-score: 389.3 E(): 2.9e-14 33.0% identity in 221 aa overlap and Streptomyces coelicolor TR:CAB59666(EMBL:AL132674) probable oxidoreductase, SCE87.21c (297 aa), fasta scores opt: 931 z-score: 1011.4 E():0 52.8% identity in 286 aa overlap. Contains a Prosite hit PS00061 Short-chain dehydrogenases/reductases family signature and a Pfam match to entry PF00106 adh_short, short [...]
  
     0.565
SCO4767
Putative regulatory protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity). Plays a positive role in prespore maturation and the initiation of sporulation septation.
       0.560
SCO2651
SC8E4A.21c, possible dehydrogenase/reductase (putative secreted protein), len: 245 aa; similar to TR:CAB52925 (EMBL:AL109949) Streptomyces coelicolor putative oxidoreductase SCJ11.40, 250 aa; fasta scores: opt: 717 z-score: 778.8 E(): 0; 47.6% identity in 250 aa overlap and to SW:LINX_PSEPA (EMBL:D23722) Pseudomonas paucimobilis 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase (EC 1.1.-.-) LinX, 250 aa; fasta scores: opt: 446 z-score: 488.9 E(): 8e-20; 34.3% identity in 248 aa overlap. Contains Pfam matches to entries PF00106 adh_short, short chain dehydrogenase and PF00678 adh_s [...]
  
 
   0.510
SCO4763
Hypothetical protein; SC6G4.41c, unknown, len: 413 aa.
       0.499
SCO0234
SCJ9A.13, probable oxidoreductase, len: 153aa; similar to many eg. SW:DHG_BACME glucose dehydrogenase from Bacillus megaterium (261 aa) fasta scores; opt: 252, z-score: 277.8, E(): 4.1e-08, (44.0% identity in 100 aa overlap). Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase.
  
 
   0.495
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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