STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO4774SCD63.06, probable glycerol phosphate dehydrogenase, len: 568 aa; similar to SW:GLPD_BACSU (EMBL:M34393) Bacillus subtilis aerobic glycerol-3-phosphate dehydrogenase (EC 1.1.99.5) GlpD, 555 aa; fasta scores: opt: 815 z-score: 910.2 E(): 0; 32.1% identity in 546 aa overlap. Contains Pfam match to entry PF01224 FAD_Gly3P_dh, FAD-dependent glycerol-3-phosphate dehydrogenase and match to Prosite entry PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. (568 aa)    
Predicted Functional Partners:
SCO0509
Glycerol kinase 2 (ATP:glycerol 3-phosphotransferase) (EC 2.7.1.30); Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.
 
 0.955
SCO1660
Putative glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.
 
 0.954
SCO7004
SC8F11.30, probable carbohydrate kinase,len: 479 aa. Highly similar to many e.g. Bacillus subtilis SW:GLPK_BACSU(EMBL:M34393) glycerol kinase (EC 2.7.1.30), GlpK (496 aa), fasta scores opt: 688 z-score: 766.4 E():0 35.1% identity in 496 aa overlap. Contains a Pfam match to entry PF00370 FGGY, FGGY family of carbohydrate kinases.
 
 0.939
SCO1661
SCI52.03, probable glycerol-3-phosphate dehydrogenase, len: 538 aa; similar to SW:GLPD_BACSU (EMBL:M34393) Bacillus subtilis aerobic glycerol-3-phosphate dehydrogenase (EC 1.1.99.5) GlpD, 555 aa; fasta scores: opt: 751 Z-score: 835.1 bits: 164.3 E(): 6.1e-39; 30.830% identity in 506 aa overlap. Contains Pfam match to entry PF01224 FAD_Gly3P_dh, FAD-dependent glycerol-3-phosphate dehydrogenase.
  
  
 
0.922
SCO5559
SC7A1.03, gpsA, glycerol-3-phosphate dehydrogenase, len: 366aa; similar to many eg. SW:GPDA_BACSU glycerol-3-phosphate dehydrogenase from Bacillus subtilis (345 aa) fasta scores; opt: 874, z-score: 1221.4, E(): 0, (41.8% identity in 330 aa overlap). Contains a possible PS00017 ATP /GTP-binding site motif A (P-loop) and Pfam match to entry PF01210 NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase, score 295.10, E-value 8.8e-85.
  
 0.919
SCO0670
SCF91.30, glpD, glycerol-3-phosphate dehydrogenase (EC 1.1.99.5), len: 527 aa. Highly similar to many prokaryotic and eukaryotic glycerol-3-phosphate dehydrogenases including: Mycobacterium tuberculosis SW:GLPD_MYCTU (EMBL:Z70692) (516 aa), fasta scores opt: 1648 z-score: 1727.9 E():0 52.6% identity in 513 aa overlap and Caenorhabditis elegans SW:GPDM_CAEEL(EMBL:Z73906) (722aa), fasta score opt: 668 z-score: 700.9 E(): 1.2e-31 33.9% identity in 537 aa overlap. Contains a Pfam match to entry PF01224 FAD_Gly3P_dh, FAD-dependent glycerol-3-phosphate dehydrogenase and a Prosite hit to PS00 [...]
  
  
 
0.916
SCO2598
SCC88.09c, probable dehydrogenase, len: 340 aa; highly similar to TR:Q9X7U9 (EMBL:AL049485) Streptomyces coelicolor putative glycerol dehydrogenase SC6A5.03, 340 aa; fasta scores: opt: 1734 z-score: 1970.7 E(): 0; 75.4% identity in 338 aa overlap and to SW:GLDA_PSEPU (EMBL:U08463) Pseudomonas putida glycerol dehydrogenase (EC 1.1.1.6) GldA, 365 aa; fasta scores: opt: 262 z-score: 302.6 E(): 1.9e-09; 25.7% identity in 335 aa overlap.
    
 0.913
SCO6754
SC6A5.03, possible glycerol dehydrogenase, len: 340aa; similar to many eg. SW:GLDA_PSEPU glycerol dehydrogenase, GldA, from Pseudomonas putida (365 aa) fasta scores; opt: 261, z-score: 303.7, E(): 1.3e-09, (27.9% identity in 308 aa overlap).
    
 0.913
SCO7005
Putative oxidoreductase; SC8F11.31, possible oxidoreductase, len: 467 aa. Similar to several including: Homo sapiens TR:AAF21941(EMBL:AF111858) dimethylglycine dehydrogenase precursor (EC 1.5.99.2) (866 aa), fasta scores opt: 217 z-score: 242.0 E(): 4.7e-06 24.7% identity in 372 aa overlap and Pyrococcus abyssi TR:CAB49193(EMBL:AJ248283) glycerol-3-phosphate dehydrogenase, GlpA (497 aa), fasta scores opt: 787 z-score: 883.5 E(): 0 36.1% identity in 454 aa overlap. Contains a Pfam match to entry PF01224 FAD_Gly3P_dh, FAD-dependent glycerol-3-phosphate dehydrogenase. Also contains a poss [...]
    
 0.911
SCO1659
Putative glycerol uptake facilitator protein; Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane (By similarity). Belongs to the MIP/aquaporin (TC 1.A.8) family.
 
  
 0.842
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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