STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO4779SCD63.11, pkaJ, serine/threonine protein kinase, len: 548 aa; N-terminal region similar to TR:CAB50939 (EMBL:AL096849) Streptomyces coelicolor putative protein serine/threonine kinase SCI11.13, 550 aa; fasta scores: opt: 1006 z-score: 815.3 E(): 0; 56.9% identity in 297 aa overlap and to TR:AAD47061 (EMBL:AF159501) Myxococcus xanthus Pkn4, 643 aa; fasta scores: opt: 639 z-score: 521.3 E(): 1.4e-21; 43.6% identity in 273 aa overlap and C-terminal similar to TR:Q9WTP4 (EMBL:AB019577) Mus musculus UNC-51-like kinase (ULK) 2, Ulk2, 1037 aa; blastp socres: Sum P(2) = 2.6e-24 Identities = 89 [...] (548 aa)    
Predicted Functional Partners:
SCO1384
SC1A8A.04c, hypothetical protein, len: 267aa; similar to but longer than SW:Q50606 (Y0DG_MYCTU) hypothetical protein from Mycobacterium tuberculosis (162 aa) fasta scores; opt: 503, z-score: 488.2, E(): 9.2e-20, 56.0% identity in 141 aa overlap. Contains Pfam match to entry PF00498 FHA, FHA domain.
 
 
 
 0.855
SCO3845
SCH69.15, possible protein phosphatase, len: 515aa; similar to many of undefined function egs. TR:P71588 (EMBL:Z80233) hypothetical protein from Mycobacterium tuberculosis (514 aa) fasta scores; opt: 989, z-score: 916.0, E(): 0, (42.9% identity in 536 aa overlap) and TR:Q50188 (EMBL:Z70722) putative phophoprotein phosphatase from Mycobacterium leprae (509 aa) fasta scores; opt: 966, z-score: 895.0, E(): 0, (40.0% identity in 530 aa overlap). Contains 2 Pfam matches to entry PF00481 PP2C, Protein phosphatase 2C. could have a role in signalling.
 
 
 0.852
SCO7530
Putative regulatory protein; SC8G12.06c, possible regulatory protein, len: 360 aa. The N-terminus of this protein is similar to many regulatory proteins e.g. Deinococcus radiodurans TR:AAF11989(EMBL:AE002074) transcriptional regulator, MerR family (280 aa), fasta scores opt: 324 z-score: 367.6 E(): 5.1e-13 37.3% identity in 244 aa overlap. The C-terminus of this protein is similar to many hypothetical proteins and putative phosphatases e.g. Mycobacterium leprae TR:Q50188(EMBL:Z70722) putative phosphoprotein phosphatase (509 aa), fasta scores opt: 709 z-score: 790.9 E(): 0 54.6% identit [...]
 
 
 0.831
SCO2450
SCC24.21, possible serine/threonine protein kinase (regulator), len: 1349 aa; N-terminal region similar to SW:PKAB_STRCO (EMBL:D86821) Streptomyces coelicolor serine/threonine protein kinase PkaB, 417 aa; blastp socres: Score = 109 (38.4 bits), Expect = 0.00070, Sum P(2) = 0.00070 Identities = 39/121 (32%), Positives = 60/121 (49%) and C-teminal region similar to SW:AFSR_STRCO (EMBL:D90155) Streptomyces coelicolor regulatory protein AfsR, 993 aa; fasta scores: opt: 510 z-score: 438.0 E(): 5.8e-17; 33.3% identity in 442 aa overlap. Contains Pfam match to entry PF00069 pkinase, Eukaryoti [...]
  
 
   0.785
SCO2667
Hypothetical protein SC6D10.10; SC6D10.10, unknown, len: 482 aa.
 
 
 0.680
SCO3848
SCH69.18, possible serine/threonine protein kinase, len: 673 aa; similar to many e.g. TR:P71584 (EMBL:Z80233) putative serine/threonine protein kinase from Mycobacterium tuberculosis (626 aa) fasta scores; opt: 1185, z-score: 1028.0, E(): 0, (42.0% identity in 646 aa overlap) and TR:P95308 (EMBL:X99618) serine/threonine protein kinase from Mycobacterium tuberculosis (662 aa) fasta scores; opt: 598, z-score: 522.8, E(): 8.6e-22, (33.9% identity in 345 aa overlap). Also similar to SCGD3.21c from Streptomyces coelicolor (522 aa) fasta scores; opt: 1104, z-score: 1039.5, E(): 0, (50.0% ide [...]
 
 
0.647
SCO2110
SC6E10.04, pkaF, probable eukaryotic-type serine/threonine protein kinase, len: 667 aa; previously sequenced as TR:Q9ZNB3 (EMBL:AB019394) S.coelicolor eukaryotic-type protein kinase (629 aa) and identical to that sequence, but with a different putative start codon. Similar to many e.g. SW:PKN2_MYXXA (EMBL:M94857), Pkn2, Myxococcus xanthus serine/threonine protein kinase involved in regulation of beta-lactamase secretion (830 aa), fasta scores; opt: 564 z-score: 531.4 E(): 2.8e-22, 35.5% identity in 366 aa overlap. Similar to many hypothetical protein serine/threonine protein kinases fr [...]
 
 
0.645
SCO3893
SCH24.15c, hypothetical protein, len: 563 aa; unknown function, previously partially sequenced as TR:O86855 (EMBL:AJ007313) Streptomyces coelicolor hypothetical protein (281 aa). Weakly similar to TR:Q53839 (EMBL:U19250) Streptomyces coelicolor protein kinase-like protein (565 aa), fasta scores; opt: 205 z-score: 204.5 E(): 0.00045, 25.1% identity in 263 aa overlap and to C-terminal half of TR:O05435 (EMBL:Z94121) Mycobacterium tuberculosis hypothetical protein (1184 aa) (26.9% identity in 557 aa overlap).
  
     0.639
SCO4778
SCD63.10, pkaI, serine/threonine protein kinase, len: 380 aa; similar to TR:CAB50939 (EMBL:AL096849) Streptomyces coelicolor putative protein serine/threonine kinase SCI11.13, 550 aa; fasta scores: opt: 932 z-score: 751.0 E(): 0; 45.0% identity in 416 aa overlap and to SW:PKAA_STRCO (EMBL:D86821) Streptomyces coelicolor serine/threonine protein kinase PkaA (EC 2.7.1.-), 543 aa; fasta scores: opt: 557 z-score: 454.6 E(): 6.8e-18; 33.9% identity in 386 aa overlap. Contains Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain and matches to Prosite entries PS00107 Protein [...]
 
   
0.554
SCO4776
SCD63.08, possible serine/threonine protein kinase, len: 979 aa; similar to TR:O83032 (EMBL:AB16932) Streptomyces coelicolor protein serine/threonine kinase PhaD, 598 aa; blastp scores: Sum P(2) = 2.4e-24 Identities = 123/403 (30%), Positives = 159/403 (39%). Contains 2x Pfam match to entry PF00069 pkinase, Eukaryotic protein kinase domain and possible hydrophobic membrane spanning region. High content in alanine, glycine and proline residues.
 
   
0.546
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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