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folD protein (Streptomyces coelicolor) - STRING interaction network
"folD" - Bifunctional protein FolD in Streptomyces coelicolor
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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folDBifunctional protein FolD; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (284 aa)    
Predicted Functional Partners:
SCO5470
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (420 aa)
 
 
  0.991
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (372 aa)
   
 
  0.989
SCO5364
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (418 aa)
 
 
  0.989
purH
Bifunctional purine biosynthesis protein PurH; Involved in de novo purine biosynthesis (523 aa)
 
  0.989
SCO4837
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (481 aa)
 
 
  0.988
SCO2614
SCC88.25c, fpgS, folylpolyglutamate synthase, len- 444 aa; identical to previously sequenced TR-O08416 (EMBL-Y13070) Streptomyces coelicolor folylpolyglutamate synthase (EC 6.3.2.17), 444 aa and similar to SW-FOLC_BACSU (EMBL-L04520) Bacillus subtilis folylpolyglutamate synthase (EC 6.3.2.17), FolC, 430 aa; fasta scoreS- opt- 622 z-score- 688.7 E()- 6.1e-31; 32.0% identity in 438 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family and matches to Prosite entries PS00398 Site-specific recombinases signature 2 and PS01012 Folylpolyglutamate synthase signature 2 (444 aa)
 
 
  0.971
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate (215 aa)
 
 
  0.969
gcvP
Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family (961 aa)
   
 
  0.969
SCO2103
SC4A10.36c, metF, 5,10-methylenetetrahydrofolate reductase, len- 307 aa; identical to SW-METF_STRLI (EMBL-AJ001630), MetF, Streptomyces lividans 5,10-methylenetetrahydrofolate reductase (307 aa), apart from substitution of Arg41 for Lys41 in S.coelicolor, fasta scores; opt- 2015 z-score- 2364.3 E()- 0, 99.7% identity in 307 aa overlap (307 aa)
   
 
  0.963
purU
Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) (297 aa)
   
 
  0.963
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor, Streptomyces coelicolor A3(2)
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