node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCO0546 | SCO2736 | gene:17758129 | gene:17760343 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | SCC57A.07c, citA, citrate synthase, len: 429 aa. Previously sequenced and characterised: Streptomyces coelicolor TR:AAF14286(EMBL:AF181118) citrate synthase (citA). Contains a Prosite hit to PS00480 Citrate synthase signature and a Pfam match to entry PF00285 citrate_synt, Citrate synthase. | 0.977 |
SCO0546 | SCO2951 | gene:17758129 | gene:17760562 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | SCE59.10c, probable malate oxidoreductase, len: 471 aa; similar to SW:MAOX_BACST (EMBL:M19485) Bacillus stearothermophilus NAD-dependent malic enzyme (EC 1.1.1.38) (NAD-ME) 478 aa; fasta scores: opt: 1778 z-score: 1887.0 E(): 0; 58.8% identity in 471 aa overlap and to SW:MAO2_ECOLI (EMBL:AE000333) Escherichia coli NADP-dependent malic enzyme (EC 1.1.1.40) MaeB, 759 aa; fasta scores: opt: 1092 z-score: 1158.4 E(): 0; 46.4% identity in 394 aa overlap Contains two Pfam matches to entry PF00390 malic, Malic enzyme. | 0.951 |
SCO0546 | SCO4388 | gene:17758129 | gene:17762033 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | SCD10.20, probable citrate synthase, len: 387 aa; similar to SW:CISY_BACSU (EMBL:U05256) Bacillus subtilis citrate synthase I (EC 4.1.3.7) CitA, 366 aa; fasta scores: opt: 615 z-score: 685.9 E(): 9.9e-31; 36.7% identity in 360 aa overlap and to TR:O70008 (EMBL:AL022374) Streptomyces coelicolor citrate synthase (EC 4.1.3.7) SC5B8.22, 390 aa; fasta scores: opt: 780 z-score: 867.9 E(): 0; 41.0% identity in 371 aa overlap. Contains 2 Pfam matches to entry PF00285 citrate_synt, Citrate synthase and match to Prosite entry PS00480 Citrate synthase signature. | 0.958 |
SCO0546 | SCO4827 | gene:17758129 | gene:17762476 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Exhibits remarkably higher catalytic efficiency for oxaloacetate reduction than for malate oxidation in vitro. Shows a high specificity for NAD(H), being almost inactive with NADP(H). | 0.970 |
SCO0546 | SCO5042 | gene:17758129 | gene:17762691 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Fumarate hydratase C; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.492 |
SCO0546 | SCO5044 | gene:17758129 | gene:17762693 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | Fumarate hydratase class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.634 |
SCO0546 | SCO5261 | gene:17758129 | gene:17762912 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 2SC7G11.23, probable malate oxidoreductase, len: 409 aa; similar to SW:MAOX_BACST (EMBL:M19485) Bacillus stearothermophilus NAD-dependent malic enzyme (EC 1.1.1.38), 478 aa; fasta scores: opt: 1385 z-score: 1470.9 E(): 0; 55.0% identity in 391 aa overlap. Contains 2x Pfam matches to entry PF00390 malic, Malic enzyme. | 0.965 |
SCO0546 | SCO5831 | gene:17758129 | gene:17763491 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | SC5B8.21c, citrate synthase-like protein, len: 421 a a; similar to citrate synthase from many organisms e.g. CIS Y_THIFE P51045 thiobacillus ferrooxidans. citrate synthase (386 aa), fasta scores; opt: 387 z-score: 460.4 E(): 1.9e-1 8, 30.2% identity in 384 aa overlap. Contains Pfam match to entry citrate_synt PF00285, Citrate synthase, score 81.00 and probable helix-turn-helix at aa 17-38 (Score 1757, +5.1 7 SD). Also similar to upstream gene SC5B8.22 (390 aa) E(): 4.5e-11, 32.8% identity in 351 aa overlap. | 0.968 |
SCO0546 | SCO5832 | gene:17758129 | gene:17763492 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | SC5B8.22, putative citrate synthase, len: 390 aa; similar to citrate synthase from many organisms e.g. CISZ _BACSU P39120 bacillus subtilis. citrate synthase i (372 aa), fasta scores; opt: 729 z-score: 877.4 E(): 0, 35.5% iden tity in 372 aa overlap. Contains PS00480 Citrate synthase s ignature and Pfam match to entry citrate_synt PF00285, Citr ate synthase, score 314.55. Also similar to downstream gene SC5B8.21c (421 aa) E(): 2.6e-14, 32.4% identity in 352 aa overlap. | 0.958 |
SCO0546 | SCO7000 | gene:17758129 | gene:17764660 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | SC8F11.26c, idh, isocitrate dehydrogenase, len: 739 aa. Shares 97.8% sequence identity with that previously sequenced and characterised: Streptomyces coelicolor isocitrate dehydrogenase Idh, 741 aa TR:Q9X5M9(EMBL:AF127018); Belongs to the monomeric-type IDH family. | 0.597 |
SCO2736 | SCO0546 | gene:17760343 | gene:17758129 | SCC57A.07c, citA, citrate synthase, len: 429 aa. Previously sequenced and characterised: Streptomyces coelicolor TR:AAF14286(EMBL:AF181118) citrate synthase (citA). Contains a Prosite hit to PS00480 Citrate synthase signature and a Pfam match to entry PF00285 citrate_synt, Citrate synthase. | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.977 |
SCO2736 | SCO2951 | gene:17760343 | gene:17760562 | SCC57A.07c, citA, citrate synthase, len: 429 aa. Previously sequenced and characterised: Streptomyces coelicolor TR:AAF14286(EMBL:AF181118) citrate synthase (citA). Contains a Prosite hit to PS00480 Citrate synthase signature and a Pfam match to entry PF00285 citrate_synt, Citrate synthase. | SCE59.10c, probable malate oxidoreductase, len: 471 aa; similar to SW:MAOX_BACST (EMBL:M19485) Bacillus stearothermophilus NAD-dependent malic enzyme (EC 1.1.1.38) (NAD-ME) 478 aa; fasta scores: opt: 1778 z-score: 1887.0 E(): 0; 58.8% identity in 471 aa overlap and to SW:MAO2_ECOLI (EMBL:AE000333) Escherichia coli NADP-dependent malic enzyme (EC 1.1.1.40) MaeB, 759 aa; fasta scores: opt: 1092 z-score: 1158.4 E(): 0; 46.4% identity in 394 aa overlap Contains two Pfam matches to entry PF00390 malic, Malic enzyme. | 0.840 |
SCO2736 | SCO4388 | gene:17760343 | gene:17762033 | SCC57A.07c, citA, citrate synthase, len: 429 aa. Previously sequenced and characterised: Streptomyces coelicolor TR:AAF14286(EMBL:AF181118) citrate synthase (citA). Contains a Prosite hit to PS00480 Citrate synthase signature and a Pfam match to entry PF00285 citrate_synt, Citrate synthase. | SCD10.20, probable citrate synthase, len: 387 aa; similar to SW:CISY_BACSU (EMBL:U05256) Bacillus subtilis citrate synthase I (EC 4.1.3.7) CitA, 366 aa; fasta scores: opt: 615 z-score: 685.9 E(): 9.9e-31; 36.7% identity in 360 aa overlap and to TR:O70008 (EMBL:AL022374) Streptomyces coelicolor citrate synthase (EC 4.1.3.7) SC5B8.22, 390 aa; fasta scores: opt: 780 z-score: 867.9 E(): 0; 41.0% identity in 371 aa overlap. Contains 2 Pfam matches to entry PF00285 citrate_synt, Citrate synthase and match to Prosite entry PS00480 Citrate synthase signature. | 0.855 |
SCO2736 | SCO4827 | gene:17760343 | gene:17762476 | SCC57A.07c, citA, citrate synthase, len: 429 aa. Previously sequenced and characterised: Streptomyces coelicolor TR:AAF14286(EMBL:AF181118) citrate synthase (citA). Contains a Prosite hit to PS00480 Citrate synthase signature and a Pfam match to entry PF00285 citrate_synt, Citrate synthase. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Exhibits remarkably higher catalytic efficiency for oxaloacetate reduction than for malate oxidation in vitro. Shows a high specificity for NAD(H), being almost inactive with NADP(H). | 0.994 |
SCO2736 | SCO5042 | gene:17760343 | gene:17762691 | SCC57A.07c, citA, citrate synthase, len: 429 aa. Previously sequenced and characterised: Streptomyces coelicolor TR:AAF14286(EMBL:AF181118) citrate synthase (citA). Contains a Prosite hit to PS00480 Citrate synthase signature and a Pfam match to entry PF00285 citrate_synt, Citrate synthase. | Fumarate hydratase C; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.968 |
SCO2736 | SCO5044 | gene:17760343 | gene:17762693 | SCC57A.07c, citA, citrate synthase, len: 429 aa. Previously sequenced and characterised: Streptomyces coelicolor TR:AAF14286(EMBL:AF181118) citrate synthase (citA). Contains a Prosite hit to PS00480 Citrate synthase signature and a Pfam match to entry PF00285 citrate_synt, Citrate synthase. | Fumarate hydratase class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.961 |
SCO2736 | SCO5261 | gene:17760343 | gene:17762912 | SCC57A.07c, citA, citrate synthase, len: 429 aa. Previously sequenced and characterised: Streptomyces coelicolor TR:AAF14286(EMBL:AF181118) citrate synthase (citA). Contains a Prosite hit to PS00480 Citrate synthase signature and a Pfam match to entry PF00285 citrate_synt, Citrate synthase. | 2SC7G11.23, probable malate oxidoreductase, len: 409 aa; similar to SW:MAOX_BACST (EMBL:M19485) Bacillus stearothermophilus NAD-dependent malic enzyme (EC 1.1.1.38), 478 aa; fasta scores: opt: 1385 z-score: 1470.9 E(): 0; 55.0% identity in 391 aa overlap. Contains 2x Pfam matches to entry PF00390 malic, Malic enzyme. | 0.840 |
SCO2736 | SCO5831 | gene:17760343 | gene:17763491 | SCC57A.07c, citA, citrate synthase, len: 429 aa. Previously sequenced and characterised: Streptomyces coelicolor TR:AAF14286(EMBL:AF181118) citrate synthase (citA). Contains a Prosite hit to PS00480 Citrate synthase signature and a Pfam match to entry PF00285 citrate_synt, Citrate synthase. | SC5B8.21c, citrate synthase-like protein, len: 421 a a; similar to citrate synthase from many organisms e.g. CIS Y_THIFE P51045 thiobacillus ferrooxidans. citrate synthase (386 aa), fasta scores; opt: 387 z-score: 460.4 E(): 1.9e-1 8, 30.2% identity in 384 aa overlap. Contains Pfam match to entry citrate_synt PF00285, Citrate synthase, score 81.00 and probable helix-turn-helix at aa 17-38 (Score 1757, +5.1 7 SD). Also similar to upstream gene SC5B8.22 (390 aa) E(): 4.5e-11, 32.8% identity in 351 aa overlap. | 0.856 |
SCO2736 | SCO5832 | gene:17760343 | gene:17763492 | SCC57A.07c, citA, citrate synthase, len: 429 aa. Previously sequenced and characterised: Streptomyces coelicolor TR:AAF14286(EMBL:AF181118) citrate synthase (citA). Contains a Prosite hit to PS00480 Citrate synthase signature and a Pfam match to entry PF00285 citrate_synt, Citrate synthase. | SC5B8.22, putative citrate synthase, len: 390 aa; similar to citrate synthase from many organisms e.g. CISZ _BACSU P39120 bacillus subtilis. citrate synthase i (372 aa), fasta scores; opt: 729 z-score: 877.4 E(): 0, 35.5% iden tity in 372 aa overlap. Contains PS00480 Citrate synthase s ignature and Pfam match to entry citrate_synt PF00285, Citr ate synthase, score 314.55. Also similar to downstream gene SC5B8.21c (421 aa) E(): 2.6e-14, 32.4% identity in 352 aa overlap. | 0.859 |
SCO2736 | SCO7000 | gene:17760343 | gene:17764660 | SCC57A.07c, citA, citrate synthase, len: 429 aa. Previously sequenced and characterised: Streptomyces coelicolor TR:AAF14286(EMBL:AF181118) citrate synthase (citA). Contains a Prosite hit to PS00480 Citrate synthase signature and a Pfam match to entry PF00285 citrate_synt, Citrate synthase. | SC8F11.26c, idh, isocitrate dehydrogenase, len: 739 aa. Shares 97.8% sequence identity with that previously sequenced and characterised: Streptomyces coelicolor isocitrate dehydrogenase Idh, 741 aa TR:Q9X5M9(EMBL:AF127018); Belongs to the monomeric-type IDH family. | 0.894 |