STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO4850SC5G8.18c, possible tetR-family transcriptional regulator, len: 251 aa; N-terminal region similar to many e.g. TR:CAB53315 (EMBL:AL109974) putative tetR-family transcriptional regulator from Streptomyces coelicolor (203 aa) fasta scores; opt: 190, z-score: 242.1, E(): 5e-06, 35.0% identity in 103 aa overlap. Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family and helix-turn-helix motif 40..61 aa. (251 aa)    
Predicted Functional Partners:
SCO4852
SC5G8.20c, possible integral membrane protein, len: 135 aa. Contains possible hydrophobic membrane spanning regions.
 
     0.931
SCO4851
Hypothetical protein; SC5G8.19c, unknown, len: 162aa.
       0.871
SCO4853
Hypothetical protein; SC5G8.21c, unknown, len: 136 aa; weakly similar to other hypothetical proteins eg. TR:AAF12497 (EMBL:AE001863) from Deinococcus radiodurans (117 aa) fasta scores; opt: 109, z-score: 149.3, E(): 0.74, 26.1% identity in 111 aa overlap.
       0.786
SCO4854
SC5G8.22c, possible integral membrane protein, len: 206aa; weakly similar to many eg. TR:P72920 (EMBL:D90901) hypothetical protein from Synechocystis sp. (strain PCC 6803) (181 aa) fasta scores; opt: 183, z-score: 238.4, E(): 8e-06, 28.8% identity in 146 aa overlap. Contains possible membrane-spanning hydrophobic regions.
       0.751
SCO4855
SC5G8.23c, dhsB, probable succinate dehydrogenase iron-sulfur subunit, len: 257aa; strongly similar to many eg. SW:P07014 (DHSB_ECOLI) succinate dehydrogenase iron-sulfur protein from Escherichia coli (238 aa) fasta scores; opt: 729, z-score: 839.1, E(): 0, 44.3% identity in 237 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains, Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains and Prosite match to PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature; Belongs to the succinate [...]
       0.679
SCO4857
SC5G8.25c, dhsD, possible succinate dehydrogenase membrane subunit, len: 160 aa; similar to TR:O53369 (EMBL:AL021841) putative membrane anchor of succinate dehydrogenase from Mycobacterium tuberculosis (144 aa) fasta scores; opt: 553, z-score: 702.9, E(): 1.1e-31, 58.9% identity in 141 aa overlap. Also weakly similar to SW:P10445 (DHSD_ECOLI) succinate dehydrogenase hydrophobic membrane anchor protein from Escherichia coli (115 aa) fasta scores; opt: 126, z-score: 172.2, E(): 0.039, 23.5% identity in 115 aa overlap. Contains possible membrane-spanning hydrophobic regions and Pfam match [...]
       0.673
SCO4858
SC5G8.26c, dhsC, possible succinate dehydrogenase membrane subunit, len: 126aa; similar to many eg. TR:O53368 (EMBL:AL021841) putative membrane anchor of succinate dehydrogenase from Mycobacterium tuberculosis (112 aa) fasta scores; opt: 484, z-score: 649.2, E(): 1e-28, 65.7% identity in 99 aa overlap. Also wealky similar to SW:P10446 (DHSC_ECOLI) succinate dehydrogenase cytochrome b-556 subunit from Escherichia coli (129 aa) fasta scores; opt: 121, z-score: 173.9, E(): 0.031, 29.6% identity in 71 aa overlap. Contains Pfam match to entry PF01127 Sdh_cyt, Succinate dehydrogenase cytochr [...]
       0.673
SCO4859
Hypothetical protein; SC5G8.27c, unknown, len: 183 aa; similar to TR:Q9Z593 (EMBL:AL035478) hypothetical protein from Streptomyces coelicolor (191 aa) fasta scores; opt: 164, z-score: 195.7, E(): 0.0019, 32.6% identity in 187 aa overlap.
       0.638
SCO4856
SC5G8.24c, dhsA, probable succinate dehydrogenase flavoprotein subunit, len: 584aa; strongly similar to many eg. SW:P10444 (DHSA_ECOLI) succinate dehydrogenase flavoprotein subunit from Escherichia coli (588 aa) fasta scores; opt: 1842, z-score: 2076.6, E(): 0, 48.4% identity in 591 aa overlap. Contains Pfam match to entry PF00890 FAD_binding_2, FAD binding domain and Prosite match to PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site.
       0.424
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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