STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
SCO4967Conserved hypothetical protein; A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S- conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics; Belongs to the MshB deacetylase family. Mca subfamily. (293 aa)    
Predicted Functional Partners:
SCO1663
Putative cysteinyl-tRNA synthetase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins.
 
  
 0.942
SCO4204
Putative glycosyltransferase; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway; Belongs to the glycosyltransferase group 1 family. MshA subfamily.
 
  
 0.935
SCO4151
Putative acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. Belongs to the acetyltransferase family. MshD subfamily.
  
   
 0.879
SCO4968
2SCK31.28, possible membrane protein, len: 75 aa. Contains possible hydrophobic membrane spanning region.
       0.875
SCO4966
2SCK31.26c, possible membrane protein, len: 132 aa; similar to TR:O53429 (EMBL:AL021897) Mycobacterium tuberculosis hypothetical 15.4 kDa protein MTV017.34c, 144 aa; fasta scores: opt: 186 z-score: 240.5 E(): 7.4e-06; 27.9% identity in 136 aa overlap. Contains possible hydrophobic membrane spanning region.
       0.782
SCO2634
SC8E4A.04c, hypothetical protein, len: 216 aa; similar to various hypothetical proteins, e.g. TR:O53193 (EMBL:AL021246) Mycobacterium tuberculosis hypothetical 23.0 kD protein MTV008.22c, 207 aa; fasta scores: opt: 789 z-score: 898.4 E(): 0; 54.9% identity in 213 aa overlap.
  
    0.776
SCO3647
SCH10.25c, conserved hypothetical protein, len: 143 aa; unknown function, similar to TR:O06310 (EMBL:Z95324) Mycobacterium tuberculosis hypothetical protein (145 aa), fasta scores; opt: 497 z-score: 431.5 E(): 1e-16, 55.8% identity in 138 aa overlap and TR:O69598 (EMBL:AL023514) Mycobacterium leprae hypothetical protein (137 aa) (56.2% identity in 130 aa overlap).
  
     0.758
SCO4956
Putative peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
  
  
 0.755
SCO4965
Putative transcription elongation factor; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.
 
     0.755
SCO5216
RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor (RsrA) until released. Responds to thiol-oxidative stress, involved in regulation of about 30 genes and operons, including the thioredoxin system (trxB-trxA, trxC), ribosomal protein L31, RNA polymerase-binding protein RbpA and mycothiol (MSH) biosynthetic (mshA) and recycling genes (mca). In conjunction with its cognate anti-s [...]
  
   
 0.687
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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