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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SCO4979Putative phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (609 aa)    
Predicted Functional Partners:
SCO0546
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
   
 
 0.981
SCO4595
SCD20.13c, probable oxidoreductase, len: 645 aa; highly similar to TR:Q9RKS4 (EMBL:AL132824) Streptomyces coelicolor putative oxidoreductase alpha-subunit SCAH10.35c, 630 aa; fasta scores: opt: 4069 z-score: 4338.6 E(): 0; 98.7% identity in 627 aa overlap and C-terminal domain similar to TR:O68228 (EMBL:AF021094) Helicobacter pylori OorA subunit of 2-oxoglutarate:acceptor oxidoreductase, 371 aa; fasta scores: opt: 495 z-score: 532.2 E(): 3.6e-22; 31.0% identity in 352 aa overlap. Contains Pfam match to entry PF01855 POR_N, Pyruvate flavodoxin/ferredoxin oxidoreductase (N terminus).
   
 
 0.971
SCO6270
SCAH10.35c, possible oxidoreductase alpha-subunit, len: 630 aa; similar to TR:O53182 (EMBL:AL021246) Mycobacterium tuberculosis oxidoreductase alpha-subunit, 653 aa; fasta scores: opt: 2008 z-score: 2153.9 E(): 0; 66.4% identity in 614 aa overlap.
   
 
 0.971
SCO3127
Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
     
 0.970
SCO4827
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Exhibits remarkably higher catalytic efficiency for oxaloacetate reduction than for malate oxidation in vitro. Shows a high specificity for NAD(H), being almost inactive with NADP(H).
 
  
 0.965
SCO0208
SCJ12.20, pyruvate phosphate dikinase, len: 898 aa. Highly similar to many pyruvate phosphate dikinases e.g. Clostridium symbiosum SW:PODK_CLOSY (EMBL; M60920)(EC 2.7.9.1) (873 aa), fasta scores opt: 1626 z-score: 1761.3 E():0 48.7% identity in 895 aa overlap and Microbispora rosea SW:BAA76347 (EMBL; AB025020) (878 aa), fasta scores opt: 3060 z-score: 3317.5 E(): 0 67.5% identity in 898 aa overlap. Contains a PS00370 PEP-utilizing enzymes phosphorylation site signature, Pfam match to entry PF01326 PPDK_N_term, Pyruvate phosphate dikinase, PEP/pyruvate binding domain and a Pfam match to [...]
     
 0.953
SCO5423
SC8F4.27c, pyk2, pyruvate kinase, len: 476 aa; strongly similar to many e.g. SW:Q46078 (KPYK_CORGL) pyruvate kinase from Corynebacterium glutamicum (Brevibacterium flavum) (475 aa) fasta scores; opt: 1693, z-score: 1907.7, E(): 0, 55.3% identity in 474 aa overlap and TRNEW:CAB52070 (EMBL:AL109732) pyruvate kinase from Streptomyces coelicolor (478 aa) fasta scores; opt: 2185, z-score: 2461.2, E(): 0, 69.3% identity in 473 aa overlap. Contains Pfam match to entry PF00224 PK, Pyruvate kinase and Prosite match to PS00110 Pyruvate kinase active site signature.
  
 
 0.953
SCO5831
SC5B8.21c, citrate synthase-like protein, len: 421 a a; similar to citrate synthase from many organisms e.g. CIS Y_THIFE P51045 thiobacillus ferrooxidans. citrate synthase (386 aa), fasta scores; opt: 387 z-score: 460.4 E(): 1.9e-1 8, 30.2% identity in 384 aa overlap. Contains Pfam match to entry citrate_synt PF00285, Citrate synthase, score 81.00 and probable helix-turn-helix at aa 17-38 (Score 1757, +5.1 7 SD). Also similar to upstream gene SC5B8.22 (390 aa) E(): 4.5e-11, 32.8% identity in 351 aa overlap.
   
 
 0.950
SCO2494
SC7A8.33c, probable pyruvate phosphate dikinase, len: 909 aa; similar to TR:CAB53432 (EMBL:AL109989) Streptomyces coelicolor pyruvate phosphate dikinase SCJ12.20, 898 aa; fasta scores: opt: 3956 z-score: 4354.7 E(): 0; 66.7% identity in 889 aa overlap and to SW:PODK_CLOSY (EMBL:M60920) Clostridium symbiosum pyruvate, phosphate dikinase (EC 2.7.9.1) (pyruvate,orthophosphate dikinase) PpdK, 873 aa; fasta scores: opt: 1765 z-score: 1941.1 E():; 51.7% identity in 899 aa overlap. Contains Pfam match to entry PF01326 PPDK_N_term, Pyruvate phosphate dikinase, PEP/pyruvate binding domain, two [...]
     
 0.947
SCO2736
SCC57A.07c, citA, citrate synthase, len: 429 aa. Previously sequenced and characterised: Streptomyces coelicolor TR:AAF14286(EMBL:AF181118) citrate synthase (citA). Contains a Prosite hit to PS00480 Citrate synthase signature and a Pfam match to entry PF00285 citrate_synt, Citrate synthase.
   
 
 0.947
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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