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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
SCO5031Alkyl hydroperoxide reductase system hypothetical protein; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. (178 aa)    
Predicted Functional Partners:
SCO5032
SCK7.05c, ahpC, alkyl hydroperoxide reductase, len:184 aa; identical to previously seqeunced TR:Q9RN72 (EMBL:AF186371) Streptomyces coelicolor A3(2) AhpC, 184 aa. Contains Pfam match to entry PF00578 AhpC-TSA, AhpC/TSA family.
 
  
 0.998
SCO5033
SCK7.06, oxyR, hydrogen peroxide sensing regulator, len: 312 aa; identical to previously sequenced TR:Q9RN71 (EMBL:AF186371) Streptomyces coelicolor A3(2) hydrogen peroxide sensing regulator OxyR, 313 aa. Contains Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family and match to Prosite entry S00044 Bacterial regulatory proteins, lysR family signature. Also contains possible helix-turn-helix motif at residues 23..44 (+3.89 SD); Belongs to the LysR transcriptional regulatory family.
 
 
 
 0.957
SCO0560
Catalase/peroxidase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
      
 0.711
SCO2180
SC5F7.21, pdhL, probable dihydrolipoamide dehydrogenase, len: 486 aa; note possible downstream translational start sites. Similar to many prokaryote and eukaryote egs. TR:Q9Z6I5 (EMBL: AF047034) dihydrolipoamide dehydrogenase from Streptomyces seoulensis (462 aa) fasta scores; opt: 2780, z-score: 3088.0, E(): 0, (90.3% identity in 462 aa overlap), TR:Q54101 (EMBL:L38646) NADH ferredoxin oxidoreductase from Saccharopolyspora erythraea (456 aa) fasta scores; opt: 1918, z-score: 2131.8, E(): 0, (64.2% identity in 452 aa overlap) and SW:DLDH_PEA dihydrolipoamide dehydrogenase from Pisum sa [...]
     
 0.710
SCO2369
SCC8A.27c, possible thiol-specific antioxidant protein, len: 152 aa; similar to many e.g. SW:O24364 (BAS1_SPIOL) 2-cys peroxiredoxin Bas1 precursor from Spinacia oleracea (Spinach) (265 aa) fasta scores; opt: 352, z-score: 450.7, E(): 1.2e-17, 39.9% identity in 158 aa overlap and SW:Q10520 (Y01J_MYCTU) hypothetical protein from Mycobacterium tuberculosis (153 aa) fasta scores; opt: 507, z-score: 648.2, E(): 1.2e-28, 48.7% identity in 150 aa overlap. Contains Pfam match to entry PF00578 AhpC-TSA, AhpC/TSA family.
 
   
 0.618
SCO1595
SCI35.17c, pheS, probable phenylalanyl-tRNA synthetase alpha chain, len: 373 aa; similar to many e.g. SYFA_ECOLI phenylalanyl-tRNA synthetase alpha chain (EC 6.1.1.20) (327 aa), fasta scores; opt: 682 z-score: 1248.8 E(): 0, 43.1% identity in 343 aa overlap. Contains PS00179 and PS00339 Aminoacyl-transfer RNA synthetases class-II signatures 1 and 2.
      
 0.590
SCO4835
Conserved hypothetical protein; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family.
      
 0.487
SCO4224
Hypothetical protein; 2SCD46.38c, unknown, len: 421aa.
      
 0.483
SCO3023
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
      
 0.481
SCO0999
Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
      
 0.477
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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