STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO5080Putative hydrolase; SCBAC28G1.06, actVA5, possible hydrolase, len: 381 aa; identical to previously sequenced TR:Q53907 (EMBL:X58833) Streptomyces coelicolor 6 ActVA region genes of the actinorhodin biosynthetic gene cluster, ActVA5, 381 aa and similar to TR:Q9F0J3 (EMBL:AF218066) Streptomyces arenae hydrolase NcnH, 405 aa; fasta scores: opt: 1391 Z-score: 1521.5 bits: 290.3 E(): 3.9e-77; 56.522% identity in 368 aa overlap. (381 aa)    
Predicted Functional Partners:
SCO5092
SCBAC28G1.18, actVB, actinorhodin polyketide possible dimerase, len: 177 aa; identical to previously sequenced SW:DIM6_STRCO (EMBL:X63449) Streptomyces coelicolor actinorhodin polyketide dimerase ActI ORF6, ActVB, 177 aa Contains Pfam match to entry PF01613 Flavin_Reduct, Flavin reductase like domain.
 
 
 0.990
SCO5081
SCBAC28G1.07, actVA6, hypothetical protein, len: 113 aa; identical to previously sequenced TR:Q53908 (EMBL:X58833) Streptomyces coelicolor 6 ActVA region genes of the actinorhodin biosynthetic gene cluster, ActVA6, 113 aa and similar to SW:TCMH_STRGA (EMBL:M80674) Streptomyces glaucescens tetracenomycin polyketide synthesis hydroxylase TcmH, 112 aa; fasta scores: opt: 193 Z-score: 247.6 bits: 51.0 E(): 3.5e-06; 43.210% identity in 81 aa overlap.
 
  
 0.983
SCO5075
SCBAC28G1.01, possible oxidoreductase, previously sequenced as ORF4, len: 167 aa; identical to C-terminal region of previously sequenced TR:Q53929 (EMBL:X62373) Streptomyces coelicolor ORF4, 306 aa; fasta scores: opt: 1029 Z-score: 1146.7 bits: 219.4 E(): 2.9e-56; 95.808% identity in 167 aa overlap. Contains match to Prosite entry PS01162 Quinone oxidoreductase / zeta-crystallin signature; SCBAC20F6.18, ORF4, possible oxidoreductase, len: 170 aa; identical to N-terminal region of the previously sequenced TR:Q53929 (EMBL:X62373) Streptomyces coelicolor ORF 4, 306 aa. Contains match to P [...]
  
  0.948
SCO5023
SCK15.25, possible secreted protein, len: 336 aa; similar to TR:CAB77312 (EMBL:AL160312) Streptomyces coelicolor putative secreted protein SCD35.28c, 361 aa; fasta scores: opt: 890 z-score: 972.2 E(): 0; 47.3% identity in 357 aa overlap. Contains possible N-terminal region signal peptide sequence.
     
  0.900
SCO5072
SCBAC20F6.15, ORF1 hydroxylacyl-CoA dehydrogenase, len: 307 aa; identical to previously sequenced TR:Q53926 (EMBL:X62373) Streptomyces coelicolor hydroxylacyl-CoA dehydrogenase ORF1, 307 aa. Contains Pfam matches to entries PF02737 3HCDH_N, 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain and PF00725 3HCDH, 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain. Contains possible hydrophobic membrane spanning region.
  
 
 0.841
SCO5079
SCBAC28G1.05, actVA4, conserved hypothetical protein, len: 294 aa; identical to previously sequenced TR:Q53906 (EMBL:X58833) Streptomyces coelicolor 6 ActVA region genes of the actinorhodin biosynthetic gene cluster, ActVA4, 294 aa.
   
 0.823
SCO6026
SC1C3.14c, probable fatty acid oxidation complex alpha-subunit, similar to many e.g. FADB_ECOLI (729 aa), fasta scores; opt: 782 z-score: 863.1 E(): 0, 29.8% identity in671 aa overlap. Contains Pfam match to entry ECH PF00378, Enoyl-CoA hydratase/isomerase, score 49.78.
  
 0.724
SCO6732
SC5F2A.15, possible fatty acid oxidative multifunctional enzyme, len: 726aa; similar to SW:FAOB_PSEFR fatty oxidation complex alpha subunit from Pseudomonas fragi (715 aa) fasta scores; opt: 1174, z-score: 1211.3, E(): 0, (33.2% identity in 717 aa overlap). Also similar to TR:O53872 (EMBL:AL022004) hypothetical protein from Mycobacterium tuberculosis (720 aa) fasta scores; opt: 3034, z-score: 3128.4, E(): 0, (64.3% identity in 717 aa overlap). Also similar to SC6A5.38 (EMBL:AL049485) possible fatty oxidation protein from Streptomyces coelicolor (733 aa) fasta scores; opt: 4069, z-score [...]
  
 0.724
SCO6789
SC6A5.38, possible fatty oxidation protein, len: 733aa; similar to many eg. SW:FADB_ECOLI FadB, a multifunctional protein from the Escherichia coli fadBA operon, encoding the fatty acid-oxidizing multienzyme complex (729 aa) fasta scores; opt: 1119, z-score: 1146.7, E(): 0, (32.3% identity in 691 aa overlap). Contains Pfam matches to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family and entry PF00725 3HCDH, 3-hydroxyacyl-CoA dehydrogenase and a Prosite match to PS00923 Aspartate and glutamate racemases signature 1.
  
 0.724
SCO5078
SCBAC28G1.04, actVA3, hypothetical protein, len: 281 aa; identical to previously sequenced TR:Q53905 (EMBL:X58833) Streptomyces coelicolor 6 ActVA region genes of the actinorhodin biosynthetic gene cluster, ActVA3, 281 aa.
       0.702
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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