STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO5087SCBAC28G1.13, actIORF1, actinorhodin polyketide beta-ketoacyl synthase alpha subunit, len: 467 aa; identical to C-terminal region of SW:KASA_STRCO (EMBL:X63449) Streptomyces coelicolor actinorhodin polyketide putative beta-ketoacyl synthase 1 ActI ORF1, 424 aa. Previously sequenced start codon at residue 44 of this sequence. Also similar to TR:CAB45606 (EMBL:AL079356) Streptomyces coelicolor polyketide beta-ketoacyl synthase alpha (WhiE locus) SC6G9.15, 424 aa; fasta scores: opt: 1706 Z-score: 1660.2 bits: 316.4 E(): 9.5e-87; 61.871% identity in 417 aa overlap. Contains Pfam matches to [...] (467 aa)    
Predicted Functional Partners:
SCO5088
SCBAC28G1.14, actIORF2, actinorhodin polyketide beta-ketoacyl synthase beta subunit (also known as chain length factor), len: 407 aa; identical to previously sequenced SW:KASB_STRCO (EMBL:X63449) Streptomyces coelicolor actinorhodin polyketide putative beta-ketoacyl synthase 2 ActI ORF2, 407 aa. Contains Pfam matches to entries PF00109 ketoacyl-synt, Beta-ketoacyl synthase, N-terminal domain and PF02801 ketoacyl-synt_C, Beta-ketoacyl synthase, C-terminal domain.
 
 
0.999
SCO5089
Actinorhodin polyketide synthase acyl carrier protein; Acyl carrier protein.
 
 0.996
SCO5086
SCBAC28G1.12c, actIII, ketoacyl reductase, len: 261 aa; identical to previously sequenced SW:ACT3_STRCO (EMBL:M19536) Streptomyces coelicolor putative ketoacyl reductase ActIII, 261 aa. Contains Pfam matches to entries PF00106 adh_short, short chain dehydrogenase and PF00678 adh_short_C2, Short chain dehydrogenase/reductase C-terminus and match to Prosite entry PS00061 Short-chain dehydrogenases/reductases family signature; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
 0.993
SCO2445
SCC24.16, probable acetyl CoA carboxylase (alpha and beta subunits), len: 458 aa; N-terminal region similar to SW:ACCD_ECOLI (EMBL:M32445) Escherichia coli acetyl-Coenzyme A carboxylase carboxyl transferase subunit beta (EC 6.4.1.2) AccD, 304 aa; fasta scores: opt: 368 z-score: 366.2 E(): 5.8e-13; 32.4% identity in 238 aa overlap and C-terminal region similar to TR:AAF10787 (EMBL:AE001970) Deinococcus radiodurans acetyl-CoA carboxylase carboxyl transferase alpha subunit DR1214, 316 aa; fasta scores: opt: 366 z-score: 364.0 E(): 7.7e-13; 39.9% identity in 223 aa overlap.
 
  
 0.981
SCO1272
2SCG18.19c, probable acyl carrier protein, len: 90 aa; similar to SW:ACPA_STRCO (EMBL:X63449) Streptomyces coelicolor actinorhodin polyketide synthase acyl carrier protein (ActI-ORF3), 86 aa; fasta scores: opt: 189 z-score: 253.9 E(): 1.2e-06; 40.2% identity in 82 aa overlap. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site and match to Prosite entry PS00012 Phosphopantetheine attachment site.
 
 0.966
SCO2777
SCC105.08, accC, acetyl/propionyl CoA carboxylase alpha subunit, len: 646 aa; similar to SW:PCCA_HUMAN (EMBL:X14608) Homo sapiens propionyl-CoA carboxylase alpha chain precursor (EC 6.4.1.3) PccA, 703 aa; fasta scores: opt: 1539 z-score: 1630.1 E(): 0; 43.0% identity in 665 aa overlap and to SW:ACCC_ECOLI (EMBL:M79446) Escherichia coli biotin carboxylase (EC 6.3.4.14), alpha subunit of acetyl CoA carboxylase (EC 6.4.1.2) AccC or FabG, 449 aa; fasta scores: opt: 1439 z-score: 1527.1 E(): 0; 47.9% identity in 451 aa overlap and to N-terminal region of TR:CAB59603 (EMBL:AL132662) Streptom [...]
 
 
 0.947
SCO4381
SCD10.13, probable acetyl/propionyl CoA carboxylase, alpha subunit, len: 614 aa; similar to TR:CAB87214 (EMBL:AL163641) Streptomyces coelicolor acetyl/propionyl CoA carboxylase, alpha subunit AccC, 646 aa; fasta scores: opt: 1088 z-score: 1184.1 E(): 0; 46.6% identity in 644 aa overlap and to SW:BCCA_MYCTU (EMBL:Z19549) Mycobacterium tuberculosis acetyl/propionyl-coenzyme A carboxylase alpha chain AccA1, 654 aa; fasta scores: opt: 939 z-score: 1022.0 E(): 0; 43.2% identity in 655 aa overlap. Contains 2x Pfam matches to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase) [...]
 
 
 0.943
SCO4921
SCK13.13c, accA2, putative acyl-CoA carboxylase complex A subunit, len: 590 aa; identical to previously sequenced TR:Q9X4K6 (EMBL:AF113603) Streptomyces coelicolor putative acyl-CoA carboxylase complex A subunit AccA2, 590 aa. Contains Pfam match to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase) and PF00364 biotin_lipoyl, Biotin-requiring enzymes and match to Prosite entry PS00867 Carbamoyl-phosphate synthase subdomain signature 2 and PS00188 Biotin-requiring enzymes attachment site.
 
 
 0.937
SCO5090
Actinorhodin polyketide synthase bifunctional cyclase/dehydratase; Is needed for correct cyclization of the oligoketide leading to isochromanequinone formation.
 
   
 0.937
SCO2387
SC4A7.15, fabD, malonyl CoA:acyl carrier protein malonyltransferase, len: 316 aa; identical to previously sequenced TR:P72391 (EMBL:X86475) Streptomyces coelicolor malonyl CoA:acyl carrier protein malonyltransferase, FabD, 316 aa and similar to SW:FABD_ECOLI (EMBL:M87040) Escherichia coli malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39) FabD, 308 aa; fasta scores: opt: 524 z-score: 551.4 E(): 2.5e-23; 36.8% identity in 315 aa overlap. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain.
 
 
 0.909
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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