STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO5126Conserved hypothetical protein; Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2- deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway; Belongs to the MshB deacetylase family. (295 aa)    
Predicted Functional Partners:
SCO4204
Putative glycosyltransferase; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway; Belongs to the glycosyltransferase group 1 family. MshA subfamily.
  
 0.989
SCO1663
Putative cysteinyl-tRNA synthetase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins.
 
  
 0.986
SCO4151
Putative acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. Belongs to the acetyltransferase family. MshD subfamily.
  
   
 0.960
SCO5127
SC9E12.12, possible integral membrane protein, len: 1450 aa. Contains possible hydrophobic membrane spanning regions.
       0.875
SCO5438
Thioredoxin; SC6A11.14, trxA2, thioredoxin, len: 104 aa; similar to many e.g. SW:P52230 (THIO_STRCO) thioredoxin TrxA from Streptomyces coelicolor (110 aa) fasta scores: opt: 360, z-score: 470.8, E(): 8.2e-19, 47.5% identity in 101 aa overlap. Contains Pfam match to entry PF00085 thiored, Thioredoxin and Prosite match to PS00194 Thioredoxin family active site; Belongs to the thioredoxin family.
      
 0.833
SCO5128
SC9E12.13, possible membrane protein, len: 775 aa; highly hydrophilic. Contains possible hydrophobic membrane spanning region.
       0.757
SCO2634
SC8E4A.04c, hypothetical protein, len: 216 aa; similar to various hypothetical proteins, e.g. TR:O53193 (EMBL:AL021246) Mycobacterium tuberculosis hypothetical 23.0 kD protein MTV008.22c, 207 aa; fasta scores: opt: 789 z-score: 898.4 E(): 0; 54.9% identity in 213 aa overlap.
  
    0.756
SCO0885
Thioredoxin; Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity).
      
 0.752
SCO1664
SCI52.06, conserved hypothetical protein, len: 265 aa; similar to TR:O06242 (EMBL:Z95388) Mycobacterium tuberculosis hypothetical 28.3 kDa protein MTCY270.35, 262 aa; fasta scores: opt: 495 Z-score: 595.6 bits: 117.9 E(): 1.4e-25; 50.951% identity in 263 aa overlap.
  
     0.690
SCO5130
SC9E12.15, possible ABC transporter integral membrane protein, len: 246 aa; similar to TR:CAB88184 (EMBL:AL352972) Streptomyces coelicolor putative ABC transporter integral membrane protein SCC30.14, 238 aa; fasta scores: opt: 516 z-score: 611.2 E(): 1.4e-26; 35.9% identity in 237 aa overlap. Contains possible hydrophobic membrane spanning regions.
       0.686
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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