STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO51922SC3B6.16c, hypothetical protein, len: 469 aa; similar to TR:O53343 (EMBL:AL021646) Mycobacterium tuberculosis ABC-transporter ATP binding protein MTV014.41, 447 aa; fasta scores: opt: 1156 z-score: 1301.9 E(): 0; 45.3% identity in 393 aa overlap. (469 aa)    
Predicted Functional Partners:
SCO5193
2SC3B6.17c, possible secreted protein, len: 442 aa; similar to TR:O53342 (EMBL:AL021646) Mycobacterium tuberculosis hypothetical 31.6 kD protein MTV014.40, 299 aa; fasta scores: opt: 233 z-score: 233.2 E(): 1.6e-05; 29.9% identity in 261 aa overlap. Contains possible N-terminal region signal peptide sequence.
       0.812
SCO2129
SC6G10.02c, hypothetical protein, len: 144 aa; similar to hypothetical proteins from Mycobacterium eg. TR:O53519 (EMBL:AL021957) hypothetical protein from Mycobacterium tuberculosis (144 aa) fasta scores; opt: 479, z-score: 620.2, E(): 3.1e-27, (49.0% identity in 143 aa overlap).
  
 
 
 0.751
SCO4198
2SCD46.12, probable DNA-binding protein, len: 141 aa; N-terminal region similar to many eg. TR:O53759 (EMBL:AL021933) putative regulatory protein from Mycobacterium tuberculosis (140 aa) fasta scores; opt: 412, z-score: 503.0, E(): 1.6e-20, 56.6% identity in 113 aa overlap. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix and two helix-turn-helix motifs; (Score 979 (+2.52 SD)) at residue 51-72 and (Score 1963 (+5.87 SD)) at residue 22-43.
  
     0.734
SCO3577
SCH17.11, possible ion-transporting ATPase, len: 325 aa; similar to N-terminus of TR:O50593 (EMBL:AB004659), arsA, ATPase subunit of Acidiphilium multivorum arsenite transport protein (583 aa), fasta scores; opt: 204 z-score: 231.6 E(): 1.4e-05, 25.8% identity in 325 aa overlap. Also similar to TR:O69647 (EMBL:AL022121) Mycobacterium tuberculosis putative anion transporting ATPase (340 aa) (52.1% identity in 328 aa overlap). Part of the N-terminus is weakly similar to the adjacent CDS SCH17.12 (481 aa) (25.9% identity in 158 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P [...]
  
     0.648
SCO3325
SCE68.23c, conserved hypothetical protein, len: 355 aa; similar to hypothetical proteins from Mycobacterium tuberculosis and Mycobacterium leprae e.g. SW:YV29_MYCTU (EMBL:Z77162) Mycobacterium tuberculosis hypothetical protein (358 aa), fasta scores; opt: 1281 z-score: 1288.1 E(): 0, 56.5% identity in 356 aa overlap. Similar to TR:O54097 (EMBL:AL021529), SC10A5.04, S.coelicolor hypothetical protein (295 aa) (64.4% identity in 278 aa overlap).
  
     0.637
SCO3578
SCH17.12, possible ion-transporting ATPase, len: 481 aa; similar to many putative arsenite-translocating ATPases and very weakly to TR:O54984 (EMBL:AF039405), arsA, Mus musculus arsenite-translocating ATPase (350 aa), fasta scores; opt: 192 z-score: 201.5 E(): 0.00068, 21.9% identity in 302 aa overlap. Similar to TR:O69648 (EMBL:AL022121) Mycobacterium tuberculosis putative anion transporting ATPase (386 aa) (51.2% identity in 441 aa overlap). Part of the N-terminus is weakly similar to the adjacent CDS SCH17.11 (325 aa) (25.9% identity in 158 aa overlap). Contains 3x degenerate PARHQK [...]
  
     0.635
SCO5899
Hypothetical protein; SC10A5.04, unknown, len: 295 aa; similar to hypothetical proteins from Mycobacterioum tuberculosis and M. leprae e.g. YV29_MYCTU Q11167 hypothetical 39.3 kd protein CY20G9.29 (358 aa), fasta scores; opt: 1075 z-score: 1514.7 E(): 0, 57.8% identity in 263 aa overlap.
  
     0.625
SCO5194
2SC3B6.18, hypothetical protein, len: 168 aa; similar to TR:CAB72040 (EMBL:AJ391262) Neisseria meningitidis hypothetical 26.6 kD protein RNI5, 230 aa; fasta scores: opt: 249 z-score: 315.5 E(): 4.2e-10; 41.7% identity in 103 aa overlap.
       0.578
SCO3326
SCE68.24c, possible epimerase, len: 353 aa; similar to many e.g. SW:GALE_SALT (EMBL:M33681), galE, Salmonella typhimurium UDP-glucose 4-epimerase (337 aa), fasta scores; opt: 209 z-score: 250.6 E(): 1.2e-06, 32.1% identity in 193 aa overlap. Similar to hypothetical proteins from Mycobacterium tuberculosis and Mycobacterium leprae e.g. SW:YV28_MYCTU (EMBL:Z77162) Mycobacterium tuberculosis putative UDP-glucose 4-epimerase (376 aa) (45.0% identity in 353 aa overlap). N-terminal half weakly similar to the corresponding region of TR:O54156 (EMBL:AL021409), SC3F7.13, S.coelicolor probable o [...]
 
    0.570
SCO4746
SC6G4.24, possible lipase, len: 420 aa; some similar ity to e.g. TR:Q59695 (EMBL:L35343) Pseudomonas putida dihy drolipoamide acetyltransferase (370 aa), fasta scores; opt: 134 z-score: 204.4 E(): 0.00041, 27.0% identity in 352 aa overlap. Contains PS00120 Lipases, serine active site and P fam match to entry PF00561 abhydrolase, alpha/beta hydrolas e fold, score 79.50, E-value 7e-20. Contains possible hydrophobic membrane spanning region.
  
  
 0.543
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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