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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
SCO5231Putative gntR-family transcriptional regulator; Global regulator that is part of the nutrient-sensing system. In the absence of glucosamine 6-P (GlcN6P), represses the phosphotransferase system (PTS) specific for the uptake of N- acetylglucosamine (PTSNag), and genes involved in the metabolism of chitin, as well as several genes involved in development, thereby linking carbon availability to morphogenesis. Also regulates the expression of the ABC transporters DasABC and NgcEFG, which are involved in N,N'-diacetylchitobiose ((GlcNAc)2) uptake. Binds to the DNA consensus sequence 5'-ACTG [...] (254 aa)    
Predicted Functional Partners:
SCO5236
Putative glucosamine phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
  
  
 0.860
SCO4230
SCD8A.03, probable response regulator, len: 223 aa; similar to TR:O86269 (EMBL:AJ001103) Lactococcus lactis ArcA protein, 233 aa; fasta scores: opt: 700 z-score: 810.0 E(): 0; 49.3% identity in 223 aa overlap and to TR:Q56180 (EMBL:U38917) Synechococcus sp. response regulator PhoB, 234 aa; fasta scores: opt: 687 z-score: 795.1 E(): 0; 48.0% identity in 229 aa overlap, and similar to many S. coelicolor response regulators, e.g. SCH22A.19c, 256 aa; fasta scores: opt: 687 z-score: 696.9 E(): 2.5e-33; 49.1% identity in 224 aa overlap. Contains Pfam matches to entries PF00072 response_reg, [...]
      
 0.794
SCO5694
1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.
      
 0.791
SCO5229
SC7E4.26c, probable permease, len: 4532 aa; similar to TR:Q47552 (EMBL:L01152) Escherichia coli proline permease (fragment) PutP, 489 aa; fasta scores: opt: 333 z-score: 378.7 E(): 1.3e-13; 23.8% identity in 495 aa overlap. Contains Pfam match to entry PF00474 SSF, Sodium:solute symporter family. Contains also possible hydrophobic membrane spanning regions; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
       0.777
SCO5230
SC7E4.27c, possible integral membrane protein, len: 94 aa. Contains possible hydrophobic membrane spanning regions.
       0.777
SCO3269
SCE39.19, possible gntR-family regulator, len: 251 aa; some similarity to many egs. TR:Q07191 (EMBL:AJ005260) KorSA protein from the integrated conjugative plasmid pSAM2 of Streptomyces ambofaciens (259 aa) fasta scores; opt: 327, z-score: 380.9, E(): 6.7e-14, (31.0% identity in 252 aa overlap) and TR:O86763 (EMBL:AL031035) KorSA transcriptional regulator from Streptomyces coelicolor cosmid 6A9 (259 aa) fasta scores; opt: 326, z-score: 379.7, E(): 7.7e-14, (28.9% identity in 249 aa overlap). Contains Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family. Also con [...]
  
     0.763
SCO3981
SCBAC25E3.18c, possible GntR-family transcriptional regulator, len: 251aa: similar to many eg. TR:Q07191 (EMBL:Z19589) KorSA regulatory protein from Streptomyces ambofaciens plasmid pSAM2 (259 aa) fasta scores; opt: 323, Z-score: 366.6, 30.952% identity (32.911% ungapped) in 252 aa overlap. Also strongly similar to TR:Q9X8E2 (EMBL:AL049573) putative GntR-family regulator SCE39.19 from Streptomyces coelicolor (251 aa) fasta scores; opt: 1603, Z-score: 1776.4, 96.386% identity (96.386% ungapped) in 249 aa overlap. Contains Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, [...]
  
     0.760
SCO3264
SCE39.14c, possible gntR-family regulator, len: 243aa; weak similarity to many egs. SW:FARR_ECOLI fatty acyl responsive regulator from Escherichia coli (240 aa) fasta scores; opt: 196, z-score: 243.9, E(): 2.8e-06, (24.3% identity in 243 aa overlap) and SW:KORA_STRLI KorA protein found to control plasmid transfer in the Streptomyces lividans plasmid pIJ101 (241 aa) fasta scores; opt: 158, z-score: 198.3, E(): 0.00098, (22.0% identity in 227 aa overlap). Contains Pfam match to entry PF00392 gntR, Bacterial regulatory proteins, gntR family and Prosite match to PS00043 Bacterial regulator [...]
  
     0.754
SCO3932
SCQ11.15c, probable gntR-family transcriptional regulator, len: 295 aa; similar to many e.g. TR:Q07191 (EMBL:Z19589), KorSA, Streptomyces ambofaciens plasmid pSAM2 transcriptional repressor (259 aa), fasta scores; opt: 292 z-score: 359.5 E(): 1.1e-12, 30.4% identity in 253 aa overlap. Also similar to CDS from other putative integrated plasmids in S.coelicolor e.g. SCE39.09c (EMBL:AL049573), korSA, regulatory protein (259 aa) (30.8% identity in 253 aa overlap). Part of a putative integrated plasmid similar to pSAM2. Contains probable helix-turn-helix motif at aa 35-56 (Score 1296, +3.60 [...]
  
     0.733
SCO5228
SC7E4.25c, possible acetyltransferase, len: 168 aa; similar to TR:Q9S2P7 (EMBL:AL096872) Streptomyces coelicolor putative acetyltransferase SC5F7.12c, 169 aa; fasta scores: opt: 151 z-score: 187.3 E(): 0.0058; 36.2% identity in 141 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family.
       0.723
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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