STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO52602SC7G11.22c, atrA, secreted protein, len: 321 aa; identical to previously sequenced TR:Q9RGW8 (EMBL:AF104994) Streptomyces coelicolor A3(2) periplasmic binding protein AtrA, 321 aa. Contains Pfam match to entry PF00497 SBP_bac_3, Bacterial extracellular solute-binding proteins, family 3 and correctly situated match to Prosite entry PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Also contains possible N-terminal region signal peptide sequence. (320 aa)    
Predicted Functional Partners:
SCO5259
Permease; 2SC7G11.21c, atrB, permease, len: 316 aa; previously sequenced as TR:Q9RGW7 (EMBL:AF104994) Streptomyces coelicolor A3(2) permease AtrB, 313 aa. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component and match to Prosite entry PS00402 Binding-protein-dependent transport systems inner membrane comp sign. Also contains possible hydrophobic membrane spanning regions.
 
 0.983
SCO5258
2SC7G11.20c, atrC, ATP-binding protein, len: 253 aa; previously sequenced as TR:Q9RGW6 (EMBL:AF104994) Streptomyces coelicolor A3(2) ATP-binding protein AtrC, 239 aa. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter and matches to Prosite entries PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature.
 
 
 0.976
SCO2829
SCE20.03, amino acid ABC transporter protein, integral membrane component, len: 233 aa. Highly similar to many including: Escherichia coli SW:GLNP_ECOLI(EMBL:X14180) glutamine transport system permease protein GlnP (219 aa), fasta scores opt: 377 z-score: 445.7 E(): 1.9e-17 27.8% identity in 212 aa overlap and Rhizobium sp. (strain NGR234) SW:Y4TF_RHISN(EMBL:AE000098) probable amino-acid ABC transporter permease protein Y4TF (238 aa), fasta scores opt: 570 z-score: 667.5 E(): 8.5e-30 45.1% identity in 204 aa overlap. Contains a Pfam match to entry PF00528 BPD_transp, Binding-protein-de [...]
 
 0.915
SCO2830
SCE20.04, probable amino acid ABC transporter protein, integral membrane component, len: 216 aa. Highly similar to several ABC transporter permeases including: Escherichia coli SW:GLNP_ECOLI(EMBL:X14180) glutamine transport system permease protein GlnP (219 aa), fasta scores opt: 378 z-score: 454.8 E(): 6e-18 33.2% identity in 217 aa overlap and Rhizobium sp. (strain NGR234) SW:Y4TG_RHISN(EMBL:AE000098) probable amino-acid ABC transporter permease protein Y4TG (231 aa), fasta scores opt: 667 z-score: 792.8 E(): 0 47.6% identity in 208 aa overlap. Contains multiple possible membrane spa [...]
 
 0.904
SCO5777
SC4H8.16c, gluA, probable glutamate uptake system ATP-binding protein, len: 258 aa; highly similar to many amino-acid uptake ATP-binding proteins eg. GLUA_CORGL P48243 glutamate transport atp-binding protein from Corynebacterium gluamicum (242 aa), fasta scores; opt: 1152 z-score: 1564.5 E(): 0, 71.5% identity in 242 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporters family signature.
 
 
 0.864
SCO2831
SCE20.05, probable amino acid ABC transporter protein, ATP-binding component, len: 261 aa. Highly similar to many ATP-binding transport protein including: Bacillus stearothermophilus SW:GLNQ_BACST(EMBL:M61017) glutamine transport ATP-binding protein GLNQ (242 aa), fasta scores opt: 758 z-score: 851.7 E():0 47.5% identity in 242 aa overlap and Thermotoga maritima TR:Q9WZ60(EMBL:AE001734) amino acid ABC transporter, ATP-binding protein (242 aa), fasta scores opt: 829 z-score: 930.4 E(): 0 54.5% identity in 242 aa overlap. Also similar to several other Streptomyces coelicolor transport pr [...]
 
 
 0.856
SCO5775
SC4H8.14c, gluC, probable glutamate permease, len: 222; similar to many members of the HisMQ subfamily of the binding-protein dependent transporters eg. GLUC_CORGL P48244 glutamate transport system permease protein from Corynebacterium glutamicum (225 aa), fasta scores; opt: 730 z-score: 1209.4 E(): 0, 58.8% identity in 199 aa overlap. Contains PS00402 Binding-protein-dependent transport systems inner membrane component signature.
 
 
 0.853
SCO5774
SC4H8.13c, gluD, probable glutamate permease, len: 299; similar to many members of the HisMQ subfamily of the binding-protein dependent transporters eg. GLUD_CORGL P48245 glutamate transport system permease protein from Corynebacterium glutamicum (273 aa), fasta scores; opt: 673 z-score: 843.4 E(): 0, 47.0% identity in 251 aa overlap. Contains PS00402 Binding-protein-dependent transport systems inner membrane component signature.
 
 
 0.850
SCO5776
SC4H8.15c, gluB, probable glutamate binding protein, len: 278 aa; similar to many members of the periplasmic solute-binding family 3 eg. GLUB_CORGL P48242 glutamate-binding protein precursor from Corynebacterium glutamicum (295 aa), fasta scores; opt: 733 z-score: 768.3 E(): 0, 46.9% identity in 277 aa overlap. Contains N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; also contains PS01039 Bacterial extracellular solute-binding proteins, family 3 signature.
 
     0.740
SCO2792
SCC105.23, adpA, araC-family transcriptional regulator, len: 398 aa; highly similar to TR:BAA86265 (EMBL:AB023785) Streptomyces griseus AdpA, 405 aa; fasta scores: opt: 2219 z-score: 2270.5 E(): 0; 84.4% identity in 410 aa overlap and to TR:Q9XA73 (EMBL:AL096822) Streptomyces coelicolor putative araC-family transcriptional regulator SCGD3.05, 334 aa; fasta scores: opt: 878 z-score: 904.2 E(): 0; 45.7% identity in 313 aa overlap. Contains Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family and match to Prosite entry PS00041 Bacterial regulat [...]
      
 0.729
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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