STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO54266-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (341 aa)    
Predicted Functional Partners:
SCO1942
SCC54.02c, pgi2, glucose-6-phosphate isomerase, len: 551 aa; Member of family of proteins conserved across prokaryotes and eukaryotes. Almost identical to another from Streptomyces coelicolor TR:O88015 (EMBL:AL031107) pgi, glucose-6-phosphate isomerase (550 aa) fasta scores; opt: 3305, z-score: 3849.4, E(): 0, (91.9% identity in 542 aa overlap). Also similar to SW:G6PI_ECOLI pgi, glucose-6-phosphate isomerase from Escherichia coli (549 aa) fasta scores; opt: 1950, z-score: 2271.0, E(): 0, (54.6% identity in 548 aa overlap) and SW:G6PI_MOUSE gpi, glucose-6-phosphate isomerase from Mus m [...]
  
 0.978
SCO6659
SC5A7.09c, pgi, glucose-6-phosphate isomerase, len: 550 aa; highly similar to many e.g. G6PI_ECOLI glucose-6-phosphate isomerase (EC 5.3.1.9) (549 aa), fasta sores; opt: 1878 z-score: 1900.7 E(): 0, 53.6% identity in 545 aa overlap. Contains PS00174 Phosphoglucose isomerase signature 2 and Pfam match to entry PF00342 PGI, Phosphoglucose isomerase, score 897.30, E-value 4.4e-266.
  
 0.978
SCO3649
Putative fructose 1,6-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.
 
 
 0.961
SCO6662
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily.
  
 
 0.942
SCO1957
SCC54.17, probable fructokinase, len: 302 aa; similar to many e.g. SW:SCRK_RHILT Frk, fructokinase from Rhizobium leguminosarum biovar trifolii (326 aa) fasta scores; opt: 617, z-score: 682.4, E(): 1.1e-30, (41.0% identity in 288 aa overlap). Contains PS00584 pfkB family of carbohydrate kinases signature 2 and Pfam match to entry PF00294 pfkB, pfkB family carbohydrate kinase, score 132.90, E-value 9.6e-41.
  
 
 0.939
SCO5852
SC9B10.19, agaY, possible tagatose-bisphosphate aldolase, len: 282 aa; similar to eg. AGAY_ECOLI P42908 tagatose-bisphosphate aldolase agaY (286 aa), fasta scores; opt: 585 z-score: 725.0 E(): 3.2e-33, 37.6% identity in 279 aa overlap.
 
 
 0.939
SCO5047
SCK7.20c, conserved hypothetical protein, len: 343 aa; similar to SW:GLPX_ECOLI (EMBL:Z11767) Escherichia coli hypothetical protein GlpX, 336 aa; fasta scores: opt: 789 z-score: 868.1 E(): 0; 46.5% identity in 325 aa overlap.
   
 
 0.931
SCO1936
Putative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily.
  
 
 0.930
SCO5423
SC8F4.27c, pyk2, pyruvate kinase, len: 476 aa; strongly similar to many e.g. SW:Q46078 (KPYK_CORGL) pyruvate kinase from Corynebacterium glutamicum (Brevibacterium flavum) (475 aa) fasta scores; opt: 1693, z-score: 1907.7, E(): 0, 55.3% identity in 474 aa overlap and TRNEW:CAB52070 (EMBL:AL109732) pyruvate kinase from Streptomyces coelicolor (478 aa) fasta scores; opt: 2185, z-score: 2461.2, E(): 0, 69.3% identity in 473 aa overlap. Contains Pfam match to entry PF00224 PK, Pyruvate kinase and Prosite match to PS00110 Pyruvate kinase active site signature.
 
 
 0.919
SCO1935
Transketolase A; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
  
 
 0.917
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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