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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCO54401,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. (774 aa)    
Predicted Functional Partners:
SCO5443
Putative alpha-amylase; Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans. Maltooligosaccharides with a degree of polymerization (DP) superior or equal to 4 are efficient acceptors, with DP6 being optimal in the GlgE- catalyzed polymerization with M1P. Is specific for the alpha-anomer of M1P as substrate, since the beta-anomer of M1P gives no activity. Alpha-D-glucose 1-phosphate cannot serve as a donor substrate, but alpha-maltosyl fluoride is an efficient donor in vitro. Exhibits an alpha-retaining catalytic [...]
 
 
 0.997
SCO5444
SC3D11.01, glgP, possible glycogen phosphorylase, len: >201aa; previously sequenced as TR:O70011 (EMBL:AJ001205). Also similar to TR:Q9YGA7 (EMBL:AF115479) maltodextrin phosphorylase from Thermococcus litoralis (831 aa) fasta scores; opt: 242, z-score: 283.2, E(): 2.3e-08, 30.9% identity in 194 aa overlap; SC6A11.20, glgP, possible glycogen phosphorylase (fragment), len: >705 aa; previously sequenced as TR:O70011 (EMBL:AJ001205). Also similar to TR:Q9YGA7 (EMBL:AF115479) maltodextrin phosphorylase from Thermococcus litoralis (831 aa) fasta scores; opt: 849, z-score: 972.3, E(): 0, 40.5 [...]
 
 0.995
SCO7335
Putative alpha-amylase; Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans. Maltooligosaccharides with a degree of polymerization (DP) superior or equal to 4 are efficient acceptors, with DP6 being optimal in the GlgE- catalyzed polymerization with M1P. Is probably involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.; Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.
 
 
 0.994
SCO6082
SCBAC1A6.06c, glgX3, glycogen debranching enzyme, len: 702 aa; similar to SW:GLGX_ECOLI (EMBL:J01616) Escherichia coli glycogen operon protein GlgX or GlyX (EC 3.2.1.*), 657 aa; fasta scores: opt: 1883 z-score: 2219.2 E(): 0; 45.5% identity in 664 aa overlap. Contains Pfam match to entry PF00128 alpha-amylase, Alpha amylase; Belongs to the glycosyl hydrolase 13 family.
 
 
0.985
SCO2649
SC8E4A.19c, probable 4-alpha-glucanotransferase, len: 711 aa; similar to SW:MALQ_MYCTU (EMBL:AL022021) Mycobacterium tuberculosis 4-alpha-glucanotransferase (EC 2.4.1.25) MalQ, 724 aa; fasta scores: opt: 2038 z-score: 2288.0 E(): 0; 47.9% identity in 727 aa overlap and to SW:MALQ_ECOLI (EMBL:M32793) Escherichia coli 4-alpha-glucanotransferase (EC 2.4.1.25) MalQ, 694 aa; fasta scores: opt: 979 z-score: 1098.2 E(): 0; 33.3% identity in 654 aa overlap.
 
 0.983
SCO7338
SC4G10.17, glgX, possible glycogen debranching enzyme, len: 715 aa. Previously sequenced region: Streptomyces coelicolor TR:Q9X947(EMBL:AJ001206) (715 aa). Highly similar to Escherichia coli SW:GLGX_ECOLI(EMBL:J01616) glycogen operon protein, GlgX (EC 3.2.1.-) (657 aa), fasta scores opt: 1948 z-score: 2333.6 E():0 47.5% identity in 673 aa overlap and Streptomyces coelicolor TR:CAB76010(EMBL:AL157916) putative glycosyl hydrolase, GlgX2 or SC3D11.13c (782 aa), fasta scores opt: 2622 z-score: 3141.4 E(): 0 58.5% identity in 725 aa overlap. Contains a Pfam match to entry PF00128 alpha-amyl [...]
 
 
0.983
SCO5442
SC6A11.18c, possible trehalose synthase, len: 566 aa; previously sequenced as TR:O54203 (EMBL:AJ001205) Streptomyces coelicolor putative trehalose synthase. Also similar to many others e.g. SW:Q99040 (DEXB_STRMU) glucan 1,6-alpha-glucosidase DexB from Streptococcus mutans (536 aa) fasta scores: opt: 867, z-score: 1015.8, E(): 0, 32.2% identity in 522 aa overlap. Contains Pfam match to entry PF00128 alpha-amylase, Alpha amylase.
  
 
 0.981
SCO5456
SC3D11.13c, glgX2, possible glycosyl hydrolase (putative secreted protein), len: 782 aa; similar to many eg. TR:Q9X947 (EMBL:AJ001206) putative glycogen debranching enzyme from Streptomyces coelicolor (715 aa) fasta scores; opt: 2630, z-score: 2693.4, E(): 0, 58.5% identity in 725 aa overlap and SW:P15067 (GLGX_ECOLI) glycogen operon protein from Escherichia coli (657 aa) fasta scores; opt: 1608, z-score: 1647.7, E(): 0, 47.2% identity in 669 aa overlap. Contains Pfam match to entry PF00128 alpha-amylase, Alpha amylase. Contains possible N-terminal region signal peptide sequence.
 
 
0.980
SCO0961
Glucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
 
  
 0.974
SCO5441
SC6A11.17c, pep2A, hypothetical protein, len: 464 aa; previously sequenced as TR:O54204 (EMBL:AJ001205).
 
  
 0.970
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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