STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SCO5443Putative alpha-amylase; Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans. Maltooligosaccharides with a degree of polymerization (DP) superior or equal to 4 are efficient acceptors, with DP6 being optimal in the GlgE- catalyzed polymerization with M1P. Is specific for the alpha-anomer of M1P as substrate, since the beta-anomer of M1P gives no activity. Alpha-D-glucose 1-phosphate cannot serve as a donor substrate, but alpha-maltosyl fluoride is an efficient donor in vitro. Exhibits an alpha-retaining catalytic [...] (675 aa)    
Predicted Functional Partners:
SCO5440
1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
 
 
 0.997
SCO5441
SC6A11.17c, pep2A, hypothetical protein, len: 464 aa; previously sequenced as TR:O54204 (EMBL:AJ001205).
 
 0.996
SCO7332
1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
 
 
 0.994
SCO2649
SC8E4A.19c, probable 4-alpha-glucanotransferase, len: 711 aa; similar to SW:MALQ_MYCTU (EMBL:AL022021) Mycobacterium tuberculosis 4-alpha-glucanotransferase (EC 2.4.1.25) MalQ, 724 aa; fasta scores: opt: 2038 z-score: 2288.0 E(): 0; 47.9% identity in 727 aa overlap and to SW:MALQ_ECOLI (EMBL:M32793) Escherichia coli 4-alpha-glucanotransferase (EC 2.4.1.25) MalQ, 694 aa; fasta scores: opt: 979 z-score: 1098.2 E(): 0; 33.3% identity in 654 aa overlap.
 
 
 0.992
SCO0962
SCM11.17c, glgA, putative glycosyl transferase, len: 387 aa; identical to previously sequenced TR:Q9X9U5 (EMBL:AJ243803) Streptomyces coelicolor putative glycosyl transferase, GlgA, 387 and similar to TR:Q9X7Z1 (EMBL:AL049497) Streptomyces coelicolor putative glycosyl transferase SC6G10.05c, 412 aa; fasta scores: opt: 352 z-score: 421.1 E(): 4.4e-16; 29.3% identity in 403 aa overlap. Contains Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1.
  
 
 0.990
SCO7333
Hypothetical protein; SC4G10.12c, pep2B, unknown, len: 453 aa. Previously sequenced Streptomyces coelicolor TR:O70013(EMBL:AJ001206) hypothetical protein, Pep2 (453 aa). Highly similar to Streptomyces coelicolor TR:CAB72417(EMBL:AL138978) hypothetical 50.3 kd protein, Pep2A or SC6A11.17c (464 aa), fasta scores opt: 1629 z-score: 1819.8 E(): 0 55.8% identity in 462 aa overlap.
 
 0.989
SCO5442
SC6A11.18c, possible trehalose synthase, len: 566 aa; previously sequenced as TR:O54203 (EMBL:AJ001205) Streptomyces coelicolor putative trehalose synthase. Also similar to many others e.g. SW:Q99040 (DEXB_STRMU) glucan 1,6-alpha-glucosidase DexB from Streptococcus mutans (536 aa) fasta scores: opt: 867, z-score: 1015.8, E(): 0, 32.2% identity in 522 aa overlap. Contains Pfam match to entry PF00128 alpha-amylase, Alpha amylase.
 
   
 0.962
SCO6082
SCBAC1A6.06c, glgX3, glycogen debranching enzyme, len: 702 aa; similar to SW:GLGX_ECOLI (EMBL:J01616) Escherichia coli glycogen operon protein GlgX or GlyX (EC 3.2.1.*), 657 aa; fasta scores: opt: 1883 z-score: 2219.2 E(): 0; 45.5% identity in 664 aa overlap. Contains Pfam match to entry PF00128 alpha-amylase, Alpha amylase; Belongs to the glycosyl hydrolase 13 family.
 
  
 0.934
SCO5444
SC3D11.01, glgP, possible glycogen phosphorylase, len: >201aa; previously sequenced as TR:O70011 (EMBL:AJ001205). Also similar to TR:Q9YGA7 (EMBL:AF115479) maltodextrin phosphorylase from Thermococcus litoralis (831 aa) fasta scores; opt: 242, z-score: 283.2, E(): 2.3e-08, 30.9% identity in 194 aa overlap; SC6A11.20, glgP, possible glycogen phosphorylase (fragment), len: >705 aa; previously sequenced as TR:O70011 (EMBL:AJ001205). Also similar to TR:Q9YGA7 (EMBL:AF115479) maltodextrin phosphorylase from Thermococcus litoralis (831 aa) fasta scores; opt: 849, z-score: 972.3, E(): 0, 40.5 [...]
  
 
 0.925
SCO7335
Putative alpha-amylase; Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans. Maltooligosaccharides with a degree of polymerization (DP) superior or equal to 4 are efficient acceptors, with DP6 being optimal in the GlgE- catalyzed polymerization with M1P. Is probably involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.; Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.
  
  
 
0.900
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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