STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO5514Acetolactate synthase small subunit; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa)    
Predicted Functional Partners:
SCO5513
SC8D9.25, ilvN, acetolactate synthase small subunit, len: 174 aa; high level of similarity to many e.g. TR:Q59817 (EMBL:L39268) IlvN, acetolactate synthase small subunit from the ilvBNC gene cluster of Streptomyces avermitilis (176 aa) fasta scores; opt: 884, z-score: 1056.9, E(): 0, (86.4% identity in 176 aa overlap).
 
 
 0.999
SCO5512
SC8D9.24, ilvB, acetolactate synthase, len: 613aa; high level of similarity to many eg. TR:Q59816 (EMBL:L39268) ilvB, acetolactate synthase from the ilvBNC gene cluster of Streptomyces avermitilis (617 aa) fasta scores; opt: 3558, z-score: 3786.3, E(): 0, (87.2% identity in 619 aa overlap). Contains PS00187 Thiamine pyrophosphate enzymes signature and Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes, score 899.00, E-value 3.2e-278.
 
 
 0.998
SCO3345
SCE7.12c, ilvD, dihydroxy acid dehydratase, len: 617aa; previously sequenced therefore almost (conflict of 3 amino acids) identical to TR:O69198 (EMBL:AF068843) ilvD, dihydroxy acid dehydratase from Streptomyces coelicolor (617 aa) fasta scores; opt: 4019, z-score: 4363.1, E(): 0, (99.2% identity in 617 aa overlap). Also similar to SW:ILVD_ECOLI ilvD, dihydroxy acid dehydratase from Escherichia coli (605 aa) fasta scores; opt: 2644, z-score: 2871.0, E(): 0, (66.5% identity in 606 aa overlap). Contains Pfam match to entry PF00920 ILVD_EDD, Dehydratase family and Prosite matches to PS008 [...]
 
 
 0.996
SCO2769
SCC57A.40c, possible acetolactate synthase, len: 564 aa. Similar to many e.g. Escherichia coli SW:ILVB_ECOLI (EMBL:J01633) acetolactate synthase isozyme I large subunit (EC 4.1.3.18) (562 aa), fasta scores opt: 732 z-score: 776.9 E(): 0 29.6% identity in 538 aa overlap. Contains a Prosite hit to PS00187 Thiamine pyrophosphate enzymes signature and a Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes.
 
 
 0.982
SCO5553
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
  
 0.981
SCO6584
SC8A6.05c, probable TPP-requiring enzyme, len: 560 a a; similar to many e.g. ILVB_MYCTU probable acetolactate synthase (EC 4.1.3.18) (547 aa), fasta scores; opt: 733 z-sco re: 1305.6 E(): 0, 36.4% identity in 557 aa overlap. Contai ns PS00187 Thiamine pyrophosphate enzymes signature and Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes, score 343.90, E-value 5e-106.
 
 
 0.979
SCO1176
SCG11A.07c, probable dihydroxy-acid dehydratase,len: 596 aa; highly similar to TR:CAB46389 (EMBL:AL096743) Streptomyces coelicolor putative dihydroxy-acid dehydratase IlvD, 576 aa; fasta scores opt: 1203 z-score: 1368.5 E(): 0; 53.2% identity in 583 aa overlap and to SW:ILVD_BACSU (EMB:L77246) Bacillus subtilis dihydroxy-acid dehydratase (EC 4.2.1.9) (Dad) (vegetative protein 110) (VEG110) 557 aa; fasta scores: opt: 695 z-score: 790.6 E(): 0; 35.9% identity in 571 aa overlap. Contains match to Pfam entry PF00920 ILVD_EDD, Dehydratase family and match to Prosite entry PS00886 Dihydroxy- [...]
 
 
 0.978
SCO1888
SCI7.06c, probable dihydroxy-acid dehydratase, len: 576aa; similar to many eg. SW:ILVD_BACSU dihydroxy-acid dehydratase from Bacillus subtilis (557 aa) fasta scores; opt: 1153, z-score: 1290.1, E(): 0, (37.0% identity in 560 aa overlap). Contains Pfam match to entry PF00920 ILVD_EDD, Dehydratase family and Prosite match to PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. Also contains a helix-turn-helix motif (+3.32 SD) 207-228aa; Belongs to the IlvD/Edd family.
 
 
 0.978
SCO5554
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
  
 0.975
SCO2528
2-ispoprylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
 
  
 0.967
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.