STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
SCO5523Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (362 aa)    
Predicted Functional Partners:
SCO2528
2-ispoprylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
  
 0.993
SCO5529
Putative 2-isopropylmalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
  
 0.991
SCO3345
SCE7.12c, ilvD, dihydroxy acid dehydratase, len: 617aa; previously sequenced therefore almost (conflict of 3 amino acids) identical to TR:O69198 (EMBL:AF068843) ilvD, dihydroxy acid dehydratase from Streptomyces coelicolor (617 aa) fasta scores; opt: 4019, z-score: 4363.1, E(): 0, (99.2% identity in 617 aa overlap). Also similar to SW:ILVD_ECOLI ilvD, dihydroxy acid dehydratase from Escherichia coli (605 aa) fasta scores; opt: 2644, z-score: 2871.0, E(): 0, (66.5% identity in 606 aa overlap). Contains Pfam match to entry PF00920 ILVD_EDD, Dehydratase family and Prosite matches to PS008 [...]
  
 0.988
SCO5522
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
 
  
 0.950
SCO4958
2SCK31.18, metB, cystathionine gamma-synthase, len: 386 aa; highly similar to TR:Q9RQ97 (EMBL:AF126953) Corynebacterium glutamicum cystathionine gamma-synthase MetB, 396 aa; fasta scores: opt: 1497 z-score: 1715.4 E(): 0; 59.2% identity in 377 aa overlap. Contains Pfam match to entry PF01053 Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme and match to Prosite entry PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1.
  
 0.934
SCO3920
SCQ11.03c, cysA, probable cystathionine/methionine gamma-synthase/lyase, len: 392 aa; previously sequenced as SW:CYSA_STRCO (EMBL:U37580), cysA, S.coelicolor putative cystathionine gamma-lyase (392 aa). Similar to many e.g. SW:MEGL_PSEPU (EMBL:D88554), mdeA, Pseudomonas putida methionine gamma-lyase (398 aa), fasta scores; opt: 608 z-score: 653.6 E(): 4.5e-29, 36.9% identity in 404 aa overlap. Highly similar to TR:Q53668 (EMBL:X91393) Streptomyces antibioticus hypothetical protein found upstream of the abaB gene (232 aa) (87.1% identity in 232 aa overlap). Contains Pfam match to PF0105 [...]
  
 0.933
SCO5553
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
  
 0.933
SCO7292
SC5F8.02c, possible threonine dehydratase, len: 319 aa. Similar to many including: Escherichia coli SW:THD2_ECOLI(EMBL:M21312) threonine dehydratase catabolic (EC 4.2.1.16) TdcB (329 aa), fasta scores opt: 609 z-score: 676.6 E(): 3.2e-30 39.4% identity in 312 aa overlap. Contains a Prosite hit to Serine/threonine dehydratases pyridoxal-phosphate attachment site and a Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme.
 
 
 0.927
SCO4089
Valine dehydrogenase (EC 1.4.1.-); Oxidative deamination of branched-chain amino acids. Oxidizes L-valine and L-alpha-aminobutyric acid efficiently, and L-isoleucine and L-leucine less efficiently. Does not act on D-valine. The catabolism of L-valine is the major source of fatty acid precursors for macrolide biosynthesis and a vital source of antibiotic precursors. Uses NAD; no activity was found with NADP. Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.925
SCO2256
3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11); Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate.; Belongs to the PanB family.
    
 0.921
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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