STRINGSTRING
cimA protein (Streptomyces coelicolor) - STRING interaction network
"cimA" - (R)-citramalate synthase in Streptomyces coelicolor
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cimA(R)-citramalate synthase; Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate (534 aa)    
Predicted Functional Partners:
leuC
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (476 aa)
 
  0.991
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate; Belongs to the LeuD family. LeuD type 1 subfamily (197 aa)
 
 
  0.958
ilvE
Probable branched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family (362 aa)
   
  0.943
ilvD
Dihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Belongs to the IlvD/Edd family (617 aa)
 
 
  0.942
SCO1176
Putative dihydroxy-acid dehydratase; Catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate; Belongs to the IlvD/Edd family (596 aa)
 
 
  0.942
SCO1888
Putative dihydroxy-acid dehydratase; Catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate; Belongs to the IlvD/Edd family (576 aa)
 
 
  0.939
SCO1546
SCL11.02c, probable aminotransferase, len- 273 aa; similar to SW-DAAA_BACSU (EMBL-)Y14082 Bacillus subtilis D-alanine aminotransferase (EC 2.6.1.21) Dat, 282 aa; fasta scores- opt- 347 z-score- 415.1 E()- 1.1e-15; 28.5% identity in 274 aa overlap. Contains Pfam match to entry PF01063 aminotran_4, Aminotransferase class IV and match to Prosite entry PS00770 Aminotransferases class-IV signature (273 aa)
 
  0.939
SCO6270
SCAH10.35c, possible oxidoreductase alpha-subunit, len- 630 aa; similar to TR-O53182 (EMBL-AL021246) Mycobacterium tuberculosis oxidoreductase alpha-subunit, 653 aa; fasta scores- opt- 2008 z-score- 2153.9 E()- 0; 66.4% identity in 614 aa overlap (630 aa)
       
  0.934
SCO4595
SCD20.13c, probable oxidoreductase, len- 645 aa; highly similar to TR-Q9RKS4 (EMBL-AL132824) Streptomyces coelicolor oxidoreductase alpha-subunit SCAH10.35c, 630 aa; fasta scores- opt- 4069 z-score- 4338.6 E()- 0; 98.7% identity in 627 aa overlap and C-terminal domain similar to TR-O68228 (EMBL-AF021094) Helicobacter pylori OorA subunit of 2-oxoglutarate-acceptor oxidoreductase, 371 aa; fasta scores- opt- 495 z-score- 532.2 E()- 3.6e-22; 31.0% identity in 352 aa overlap. Contains Pfam match to entry PF01855 POR_N, Pyruvate flavodoxin/ferredoxin oxidoreductase (N terminus) (645 aa)
       
  0.934
SCO4921
SCAH10.36c, accA1, probable acyl-CoA carboxylase complex (partial), len- >137 aa; identical to previously sequenced TR-AAD28553 (EMBL-AF113603) Streptomyces coelicolor acyl-CoA carboxylase complex A subunit, AccA1, 590 aa, to TR-AAD37851 (EMBL-AF126429) Streptomyces venezuelae JadJ, 584 aa; fasta scores- opt- 674 z-score- 748.1 E()- 0; 79.7% identity in 138 aa overlap and to TR-Q54119 (EMBL-X92557) Saccharopolyspora erythraea (Streptomyces erythraeus) biotin carboxylase and biotin carboxyl carrier protein BcpA2, 591 aa; fasta scores- opt- 455 z-score- 508.1 E()- 6.3e-21; 55.6% identity [...] (590 aa)
   
 
  0.917
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor, Streptomyces coelicolor A3(2)
Server load: low (10%) [HD]