STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCO5621RNA polymerase sigma factor WhiG; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (280 aa)    
Predicted Functional Partners:
SCO4184
SCD66.21, amfC, aerial mycelium formation, len: 222 aa; identical to previously sequenced TR:Q54191 (EMBL:D63677) Streptomyces coelicolor aerial micelium formation AmfC, 222 aa.
  
 
 
 0.992
SCO1950
Hypothetical protein; Involved in cell division and chromosome segregation (By similarity). Involved in sporulation. May coordinate the cessation of aerial hyphae growth and subsequent chromosome segregation and/or septation. Required for expression of the ParB partioning protein during sporogenesis. Activates its own transcription and represses WhiB. Binds with low affinity to its own promoter and to the Parp2 sporulation-specific promoter. Also binds directly to the RNA polymerase sigma factor WhiG, leading to inhibition of WhiG-dependent transcription in a dose-dependent manner ; Be [...]
      
 0.977
SCO1489
SC9C5.13, bldD, putative DNA-binding protein, len: 167 aa; identical to previously sequenced TR:O52732 (EMBL:AF045549) Streptomyces coelicolor putative DNA binding protein BldD, 167 aa. Contains Pfam match to entry PF01381 HTH_3, Helix-turn-helix.
  
   
 0.946
SCO5723
SC3C3.09c, possible regulator, BldB, len: 98 aa; identical to TR:Q53842 (EMBL:U28930) bldB (98 aa) and similar to S. coelicolor TR:Q53896 (EMBL:X60316) AbaA ORFD (75 aa), fasta scores; opt: 150 z-score: 201.9 E(): 0.00055, 47.4% identity in 57 aa overlap.
      
 0.895
SCO2082
Cell division protein; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
     
 0.835
SCO5622
SC2E1.39, possible transcriptional regulator, len: 185 aa; equivalent to Streptomyces roseosporus TR:P72569 (EMBL:U58281) tetR homologue WhiR (179 aa) (86.6% identity in 179 aa overlap) and similar to several putative transcriptional regulators of the tetR family e.g. TR:E1247678 putative transcriptional regulator SC10A5.11 (S.coelicolor) (198 aa), fasta scores; opt: 434 z-score: 720.5 E(): 6.8e-33, 41.5% identity in 171 aa overlap. Contains probable helix-turn-helix motif at aa 29 to 50 (Score 1618, +4.70 SD) and Pfam match to entry tetR PF00440, Bacterial regulatory proteins, tetR fa [...]
 
     0.799
SCO2792
SCC105.23, adpA, araC-family transcriptional regulator, len: 398 aa; highly similar to TR:BAA86265 (EMBL:AB023785) Streptomyces griseus AdpA, 405 aa; fasta scores: opt: 2219 z-score: 2270.5 E(): 0; 84.4% identity in 410 aa overlap and to TR:Q9XA73 (EMBL:AL096822) Streptomyces coelicolor putative araC-family transcriptional regulator SCGD3.05, 334 aa; fasta scores: opt: 878 z-score: 904.2 E(): 0; 45.7% identity in 313 aa overlap. Contains Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family and match to Prosite entry PS00041 Bacterial regulat [...]
      
 0.796
SCO3926
SCQ11.09, ssgA, probable regulator, len: 136 aa; highly similar to TR:P95753 (EMBL:D50051), SsgA, Streptomyces griseus protein associated with sporulation and cell division (136 aa), fasta scores; opt: 715 z-score: 896.6 E(): 0, 77.9% identity in 136 aa overlap and similar to others from S.coelicolor e.g. SC5F2A.05c (EMBL:AL049587) possible regulator (138 aa) (35.7% identity in 115 aa overlap) and SC5H1.03 (EMBL:AL049863) possible regulator (142 aa) (2.5% identity in 114 aa overlap), both annotated by similarity to Streptomyces griseus SsgA. The start codon was selected by similarity t [...]
  
   
 0.792
SCO4654
DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.759
SCO4655
DNA-directed RNA polymerase beta' chain (fragment); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.748
Your Current Organism:
Streptomyces coelicolor
NCBI taxonomy Id: 100226
Other names: S. coelicolor A3(2), Streptomyces coelicolor A3(2)
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